3099 – REPRESSION OF TBL1XR1 BY MIR-130A REINFORCES THE ABERRANT MOLECULAR PROGRAM IN T(8,21) AML

Gabriela Krivdova; Veronique Voisin; Erwin Schoof; Alex Murison; Eric Lechman; John Dick

doi:10.1016/j.exphem.2020.09.112

3099 – REPRESSION OF TBL1XR1 BY MIR-130A REINFORCES THE ABERRANT MOLECULAR PROGRAM IN T(8,21) AML

Gabriela Krivdova^*
, Veronique Voisin
, Erwin Schoof
, Alex Murison
, Eric Lechman
, John Dick

^*Corresponding author for this work

Department of Biotechnology and Biomedicine

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Deregulation of self-renewal and differentiation programs are central to the pathogenesis of hematologic malignancies. MicroRNAs (miRNAs) represent a large class of post-transcriptional regulators that mediate repression of multiple target mRNAs and are frequently deregulated in acute myeloid leukemia (AML). To identify miRNA(s) that play a functional role in human hematopoiesis, we performed an in vivo competitive repopulation screen in which candidate miRNAs were over-expressed (OE) in human CD34+CD38- umbilical cord blood (CB) cells and subsequently transplanted into immune-deficient mice for 24 weeks. miR-130a was shown to enhance long-term hematopoietic reconstitution and chosen for further investigation.

Original language	English
Article number	3099
Journal	Experimental Hematology. Supplement
Volume	88
Issue number	Supplement
Pages (from-to)	S69-S69
Number of pages	1
ISSN	0256-9280
DOIs	https://doi.org/10.1016/j.exphem.2020.09.112
Publication status	Published - 2020
Event	49th Annual Scientific Meeting of the ISEH: International Society for Experimental Hematology - Online event Duration: 19 Aug 2020 → 21 Aug 2020

Conference

Conference	49th Annual Scientific Meeting of the ISEH
City	Online event
Period	19/08/2020 → 21/08/2020

Access to Document

10.1016/j.exphem.2020.09.112

OpenUrl availability

Full text

Cite this

@article{cdd4a7cc5cf648f494c22867cc00e706,

title = "3099 – REPRESSION OF TBL1XR1 BY MIR-130A REINFORCES THE ABERRANT MOLECULAR PROGRAM IN T(8,21) AML",

abstract = "Deregulation of self-renewal and differentiation programs are central to the pathogenesis of hematologic malignancies. MicroRNAs (miRNAs) represent a large class of post-transcriptional regulators that mediate repression of multiple target mRNAs and are frequently deregulated in acute myeloid leukemia (AML). To identify miRNA(s) that play a functional role in human hematopoiesis, we performed an in vivo competitive repopulation screen in which candidate miRNAs were over-expressed (OE) in human CD34+CD38- umbilical cord blood (CB) cells and subsequently transplanted into immune-deficient mice for 24 weeks. miR-130a was shown to enhance long-term hematopoietic reconstitution and chosen for further investigation.",

author = "Gabriela Krivdova and Veronique Voisin and Erwin Schoof and Alex Murison and Eric Lechman and John Dick",

year = "2020",

doi = "10.1016/j.exphem.2020.09.112",

language = "English",

volume = "88",

pages = "S69--S69",

journal = "Experimental Hematology. Supplement",

issn = "0256-9280",

publisher = "Elsevier",

number = "Supplement",

note = "49th Annual Scientific Meeting of the ISEH : International Society for Experimental Hematology, ISEH 2020 ; Conference date: 19-08-2020 Through 21-08-2020",

}

TY - JOUR

T1 - 3099 – REPRESSION OF TBL1XR1 BY MIR-130A REINFORCES THE ABERRANT MOLECULAR PROGRAM IN T(8,21) AML

AU - Krivdova, Gabriela

AU - Voisin, Veronique

AU - Schoof, Erwin

AU - Murison, Alex

AU - Lechman, Eric

AU - Dick, John

PY - 2020

Y1 - 2020

N2 - Deregulation of self-renewal and differentiation programs are central to the pathogenesis of hematologic malignancies. MicroRNAs (miRNAs) represent a large class of post-transcriptional regulators that mediate repression of multiple target mRNAs and are frequently deregulated in acute myeloid leukemia (AML). To identify miRNA(s) that play a functional role in human hematopoiesis, we performed an in vivo competitive repopulation screen in which candidate miRNAs were over-expressed (OE) in human CD34+CD38- umbilical cord blood (CB) cells and subsequently transplanted into immune-deficient mice for 24 weeks. miR-130a was shown to enhance long-term hematopoietic reconstitution and chosen for further investigation.

AB - Deregulation of self-renewal and differentiation programs are central to the pathogenesis of hematologic malignancies. MicroRNAs (miRNAs) represent a large class of post-transcriptional regulators that mediate repression of multiple target mRNAs and are frequently deregulated in acute myeloid leukemia (AML). To identify miRNA(s) that play a functional role in human hematopoiesis, we performed an in vivo competitive repopulation screen in which candidate miRNAs were over-expressed (OE) in human CD34+CD38- umbilical cord blood (CB) cells and subsequently transplanted into immune-deficient mice for 24 weeks. miR-130a was shown to enhance long-term hematopoietic reconstitution and chosen for further investigation.

U2 - 10.1016/j.exphem.2020.09.112

DO - 10.1016/j.exphem.2020.09.112

M3 - Journal article

SN - 0256-9280

VL - 88

SP - S69-S69

JO - Experimental Hematology. Supplement

JF - Experimental Hematology. Supplement

IS - Supplement

M1 - 3099

T2 - 49th Annual Scientific Meeting of the ISEH

Y2 - 19 August 2020 through 21 August 2020

ER -

3099 – REPRESSION OF TBL1XR1 BY MIR-130A REINFORCES THE ABERRANT MOLECULAR PROGRAM IN T(8,21) AML

Abstract

Conference

Access to Document

OpenUrl availability

Fingerprint

Cite this