3099 – REPRESSION OF TBL1XR1 BY MIR-130A REINFORCES THE ABERRANT MOLECULAR PROGRAM IN T(8,21) AML

Gabriela Krivdova*, Veronique Voisin, Erwin Schoof, Alex Murison, Eric Lechman, John Dick

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Deregulation of self-renewal and differentiation programs are central to the pathogenesis of hematologic malignancies. MicroRNAs (miRNAs) represent a large class of post-transcriptional regulators that mediate repression of multiple target mRNAs and are frequently deregulated in acute myeloid leukemia (AML). To identify miRNA(s) that play a functional role in human hematopoiesis, we performed an in vivo competitive repopulation screen in which candidate miRNAs were over-expressed (OE) in human CD34+CD38- umbilical cord blood (CB) cells and subsequently transplanted into immune-deficient mice for 24 weeks. miR-130a was shown to enhance long-term hematopoietic reconstitution and chosen for further investigation.
Original languageEnglish
Article number3099
JournalExperimental Hematology. Supplement
Volume88
Issue numberSupplement
Pages (from-to)S69-S69
Number of pages1
ISSN0256-9280
DOIs
Publication statusPublished - 2020
Event49th Annual Scientific Meeting of the ISEH: International Society for Experimental Hematology - Online event
Duration: 19 Aug 202021 Aug 2020

Conference

Conference49th Annual Scientific Meeting of the ISEH
CityOnline event
Period19/08/202021/08/2020

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