Abstract
Acidification of target water with H2SO4 in a specially constructed glassy carbon/polyethylene apparatus allowed for recovery of up to 82% of [18F]fluoride as [18F]HF gas. The [18F]HF distillate was found to be acid-free but moist; when passed through a solution of tBuPh2SiOTf, it yielded [18F]tBuPh2SiF. The multivariate design of experiment showed that the key to high yield of [18F]HF was the efficient degassing of the reaction mixture.
Original language | English |
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Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 54 |
Issue number | 13 |
Pages (from-to) | 816 |
ISSN | 0362-4803 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- Hevesy laboratory