[18F]FLT PET for non-invasive assessment of tumor sensitivity to chemotherapy: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice

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[18F]FLT PET for non-invasive assessment of tumor sensitivity to chemotherapy: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice. / Munk Jensen, Mette; Erichsen, Kamille Dumong; Björkling, Fredrik; Madsen, Jacob; Jensen, Peter Buhl; Sehested, Maxwell; Højgaard, Liselotte; Kjær, Andreas.

In: P L o S One, Vol. 7, No. 11, 2012, p. e50618.

Research output: Contribution to journalJournal article – Annual report year: 2012Researchpeer-review

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Munk Jensen, Mette ; Erichsen, Kamille Dumong ; Björkling, Fredrik ; Madsen, Jacob ; Jensen, Peter Buhl ; Sehested, Maxwell ; Højgaard, Liselotte ; Kjær, Andreas. / [18F]FLT PET for non-invasive assessment of tumor sensitivity to chemotherapy: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice. In: P L o S One. 2012 ; Vol. 7, No. 11. pp. e50618.

Bibtex

@article{13abb3b4aadf407a864bbc5f1410d2f2,
title = "[18F]FLT PET for non-invasive assessment of tumor sensitivity to chemotherapy: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice",
abstract = "Treatment of A2780 xenografts in mice with TP202377 (single dose i.v.) caused a significant decrease in cell proliferation assessed by [18F]FLT PET after 6 hours. Inhibition persisted at Day 1; however, cell proliferation had returned to baseline at Day 6. In the resistant A2780/Top216 and SW620 tumor models uptake of [18F]FLT did not change after treatment. With [18F]FLT PET it was possible to distinguish non-invasively between sensitive and resistant tumors already 6 hours after treatment initiation.",
author = "{Munk Jensen}, Mette and Erichsen, {Kamille Dumong} and Fredrik Bj{\"o}rkling and Jacob Madsen and Jensen, {Peter Buhl} and Maxwell Sehested and Liselotte H{\o}jgaard and Andreas Kj{\ae}r",
note = "This study was funded by the National Advanced Technology Foundation, Danish Medical Research Council, Rigshospitalets Research Foundation, Svend Andersen Foundation, AP M{\o}ller Foundation, Novo Nordisk Foundation, Lundbeck Foundation and Danish Cancer Society. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript {\circledC} 2012 Munk Jensen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2012",
doi = "10.1371/ journal.pone.0050618",
language = "English",
volume = "7",
pages = "e50618",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - [18F]FLT PET for non-invasive assessment of tumor sensitivity to chemotherapy: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice

AU - Munk Jensen, Mette

AU - Erichsen, Kamille Dumong

AU - Björkling, Fredrik

AU - Madsen, Jacob

AU - Jensen, Peter Buhl

AU - Sehested, Maxwell

AU - Højgaard, Liselotte

AU - Kjær, Andreas

N1 - This study was funded by the National Advanced Technology Foundation, Danish Medical Research Council, Rigshospitalets Research Foundation, Svend Andersen Foundation, AP Møller Foundation, Novo Nordisk Foundation, Lundbeck Foundation and Danish Cancer Society. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript © 2012 Munk Jensen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2012

Y1 - 2012

N2 - Treatment of A2780 xenografts in mice with TP202377 (single dose i.v.) caused a significant decrease in cell proliferation assessed by [18F]FLT PET after 6 hours. Inhibition persisted at Day 1; however, cell proliferation had returned to baseline at Day 6. In the resistant A2780/Top216 and SW620 tumor models uptake of [18F]FLT did not change after treatment. With [18F]FLT PET it was possible to distinguish non-invasively between sensitive and resistant tumors already 6 hours after treatment initiation.

AB - Treatment of A2780 xenografts in mice with TP202377 (single dose i.v.) caused a significant decrease in cell proliferation assessed by [18F]FLT PET after 6 hours. Inhibition persisted at Day 1; however, cell proliferation had returned to baseline at Day 6. In the resistant A2780/Top216 and SW620 tumor models uptake of [18F]FLT did not change after treatment. With [18F]FLT PET it was possible to distinguish non-invasively between sensitive and resistant tumors already 6 hours after treatment initiation.

U2 - 10.1371/ journal.pone.0050618

DO - 10.1371/ journal.pone.0050618

M3 - Journal article

VL - 7

SP - e50618

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 11

ER -