αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus

J. Nakawesi, S. This, J. Hütter, M. Boucard-Jourdin, V. Barateau, K. Getachew Muleta, L. J. Gooday, K. Fog Thomsen, A. G. López, I. Ulmert, D. Poncet, B. Malissen, H. Greenberg, O. Thaunat, T. Defrance, H. Paidassi*, K. Lahl*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGFβ-activating integrin αvβ8 by cDC1. In contrast, αvβ8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are crucial in driving IgA during steady state but are dispensable for RV-specific IgA responses, we propose that the capacity of DC subsets to induce intestinal IgA responses reflects the context, as opposed to an intrinsic property of individual DC subsets.
Original languageEnglish
JournalMucosal Immunology
Volume14
Pages (from-to)53–67
ISSN1933-0219
DOIs
Publication statusPublished - 2021

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