Understanding basic mechanisms of efficient immune activation by a fish DNA vaccine and application in optimized vaccine design (39670)

Project Details


Despite advantages compared to other recombinant vaccines, few DNA vaccines are used commercially in veterinary and human medicine due to low protective effects. In this project, we aim to implement a proteomics and transcriptomics approach to dissect the immune response mechanisms triggered by a highly successful fish DNA vaccine and apply this knowledge in design of improved generic strategies for this innovative type of vaccines.

One key element seems to be that expression of the viral glycoprotein encoded by the DNA vaccine triggers an IFN response, which not only provides early protection but also paves the way for adaptive immunity. Such adjuvant activity is probably needed and following identification of the involved immune pathways we will identify/design suitable TLR ligands to be tested as adjuvant for less efficient vaccine constructs.

Further, we also aim to implement virus like particles (VLPs) as delivery vehicles for improved cellular uptake of DNA vaccines with or without adjuvant.

National Institute of Aquatic Resources, DTU Aqua (coordinator)
Department of Biotechnology and Biomedicine, DTU Bioengeneering 

The project is funded by the Independent Danish Council, Technology and Production (FTP).

Research area: Fish and Shellfish Diseases
Effective start/end date01/01/2020 → 31/12/2022


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