Towards accurate prediction of T cell targets; Learning the rules of T cell receptor interactions


The cellular immune system constitutes highly sophisticated mechanisms to fight
infections. Here, T cells scrutinize the surface of cells for foreign peptides presented
in complex with MHC (Major histocompatibility complex) molecules to check if the
cell has been infected. Upon identification of such foreign peptides, the T cells
activate an immune reaction aiming to clearance of the infection. T cells utilize a
protein called T cell receptor (TCR) to detect foreign peptides. A huge number of
TCR exist, each variant recognizing only a small number of peptides. Currently, the
rules determining if a TCR reacts to a specific peptide are not well characterized.
Here, we propose a unique approach to change this and arrive at a precise
understanding of TCR specificity. Using pioneer technology, we will collect
unprecedented data concerning binding between TCRs and peptides, and apply
advanced bioinformatics to this data in order to unravel the rules that dictate TCR
Effective start/end date01/08/201731/07/2020


  • immunology
  • biochnology
  • Health
  • DNA