The use of antisense-techniques for metabolic engineering of filamentous fungi

  • Aleksenko, Alexei Y. (Project Manager)
  • Nielsen, Jens (Project Participant)

    Project Details


    Antisense mRNA for the carbon catabolite repressor gene CreA was expressed in a strain of Aspergillus nidulans producing Aspergillus oryzae alpha-amylase. The recombinant strain had a significantly decreased carbon catabolite repression of alpha-amylase production, and the productivity was therefore several times higher in the recombinant strain than in a wild type.
    Effective start/end date01/10/199801/07/2000


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