Test strategy for mixtures of chemicals migrating from food contact materials (FCM)

  • Petersen, Jens Højslev, (Project Manager)
  • Trier, Xenia, (Project Participant)
  • Hadrup, Niels, (Project Participant)
  • Dybdahl, Marianne, (Project Participant)
  • Vinggaard, Anne Marie (Project Participant)
  • Taxvig, Camilla (Project Participant)
  • Binderup, Mona-Lise, (Project Participant)


A multidisciplinary project team develops and validate a test strategy for testing migration of chemicals from food contact materials that may pose a toxicological risk. Substances which have the potential to migrate into food are initially screened for a range of toxicological effects in various in vitro tests. Migrates which produce a positive response in these tests are investigated further by chemical analysis in order to identify the toxic substances. In case of the occurrence of several active substances possible endocrine disrupting “mixture effects” are elucidated. In order to access the food safety risk, migration of identified chemicals into food and/or appropriate food simulants is estimated.
Project financing
This project is part of a major research initiative funded by the National Food Authorities to study the mechanisms and effect of endocrine disrupting chemicals in food.
Effective start/end date01/07/201131/12/2014


  • migration
  • mixture effect
  • endocrine disrupters
  • in vitro tests
  • screening analysis
  • identification