Aminoalditols can be subjected to ring-closure with anhydrous HF and formic acid under formation of amino/hydroxy-tetrahydrofurans. Use of trifluoroacetic acid gives acyloxyiniumions. It is possible to control the ring-closure by varying the carboxylic acid. Functionalized tetrahydrofurans are important building units in natural products.
|Effective start/end date||01/01/1995 → …|
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