Specific determination of dithiocarbamates in foods and exposure assessment

Project Details

Description

Development of an analytical method by which it is possible to determine the different DTCs qualitatively and quantitatively, which will be very useful for the authorities of the different EU Member States for enforcement purposes. Furthermore this will enable a more correct estimation of the residue levels in our food and the dietary intake of the different DTCs. Currently only a rough estimate of the human dietary intake of dithiocarbamates (DTCs) is known, due to lack of accuracy, specificity and selectivity of the currently applied analytical methods. The data produced will form the basis of a comprehensive assessment of the dietary exposure to DTCs.

Aims:

To develop a specific and selective analytical method which will enable enforcement of current regulation for dithiocarbamates, e.g. control of illegal use of dithiocarbamates or exeedances of MRLs.
Perform DTC-conserving sample preparation by means of cryogenic homogenisation with liquid nitrogen.
Detection of DTCs and their main degradation product, ETU and PTU with an analytical platform, which combine HPLC instrumentation for separation with state-of-the-art ICP-MS and ESI-MS/MS for simultaneous interference-free detection of sulphur in the DTCs as well as the associated manganese or zinc ions.
To estimated the exposure of DTCs and ETU from fruit and vegetables.
Analyses of 150 samples of Danish produced and imported fruit and vegetables
Probabalistic intake calculations based on the residues found in fruit and vegetables.
StatusFinished
Effective start/end date01/01/200830/06/2011