Quantification of exposure to AMR through different transmission routes from animals to humans

Project Details

Description

This project is part of the EU Consortium “Ecology from Farm to Fork Of microbial drug Resistance and Transmission” (EEFORT). Our work package (WP7) will focus on the development of two source attribution approaches for antimicrobial resistance determinants.
The first approach will estimate the relative exposure to AMR determinants through various transmission routes. This comparative exposure assessment model aims at representing the overall EU population by including data from a representative set of countries, and will include farm and retail data from various food transmission routes such as pork, chicken, turkey, veal and fish.
The second model will use a microbial subtyping approach and will be developed to estimate the relative importance of food animals, pets and environmental sources for the exposure to AMR determinants in occupational risk groups constituted by people working in farms and slaughterhouses. The source-attribution model will be based on the comparison of bacterial genetic profiles found in the various sources with the ones found in humans based on DNA sequence data. Sources will include food-production animals (broilers and pigs), environmental routes and direct contact with pets in farms. The output of this model will be the number of humans that have been exposed to AMR determinants through each source.
The EFFORT project will provide scientific evidence and high quality data that will inform decision makers, the scientific community and other stakeholders about the consequences of Anti-Microbial Resistance (AMR) in the food chain, in relation to animal health and welfare, food safety and economic aspects.
Source attribution of antimicrobial resistance determinants.
StatusFinished
Effective start/end date01/01/201531/12/2019

Keywords

  • Antimicrobial resistance
  • Source-attribution
  • Risk assessment
  • whole genome sequencing
  • qPCR