Prevention of Cancer by Intervention with Selenium (PRECISE)

  • Overvad, Kim (Project Participant)
  • Cold, Søren (Project Participant)
  • Adami, Hans Olav (Project Participant)
  • Rayman, Margaret (Project Participant)
  • Larsen, Erik Huusfeldt (Project Manager)
  • Sloth, Jens Jørgen (Project Participant)

Project Details


In order to test the possible role of selenium in cancer prevention, a group of researchers from Denmark, Sweden and from the UK have designed the Prevention of Cancer by Intervention with Selenium (PRECISE) study. Over a period of 8 years a planned total of 42000 Europeans will be randomised to supplementation with yeast-selenium at 100, 200 and 300 µg/day or placebo.

Pilot studies have been conducted in Denmark and in the UK from 1999-2004, and the biomarkers of selenium intake show good response and compliance to the supplements. No adverse effects were recorded.

The task of the National Food Institute is to aid in the study design and assure quality of the selenium supplementation tablets to be used. In case of a positive outcome of the PRECISE trial, the National Food Institute will devise ways to raise the selenium intake in the general population.
Effective start/end date01/01/200201/01/2015


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