In recent years, a composite picture of the biological roles of oligosaccharides has emerged. Certain oligosaccharides can act as highly specific receptors for a variety of viruses, bacteria, and parasites. They are receptors for many plant and bacterial toxins, and serve as antigens for autoimmune reactions. Also, since all cells are covered with a dense coating of sugars, it has long been predicted that oligosaccharides must be critical determinants of cell-cell interactions. Reagents which inhibit, modify, or mimic such specific carbohydrate-protein interactions are of great pharmaceutical importance and may lead to new pharmaceuticals for immunology, inflammation, and oncology. The aim of this project is to develop new and general techniques for the solid-phase synthesis of oligosaccharides. The research plan calls for (1) investigation of new handle strategies for solid-phase anchoring of oligosaccharides; (2) development of a technique for the stereospecific glycosylation; and (3) combinatorial synthesis of oligosaccharide libraries.
|Effective start/end date||01/09/1997 → …|