Mitigating the impact of PRV-3 infection in Rainbow trout production by high throughput diagnostic platforms (PRVent) (39654 & 39665)

Project Details


PRVent aims to counteract a recently discovered viral disease in farmed Danish rainbow trout with high negative impact on modern aquaculture production based on environment friendly Recirculated Aquaculture Systems (RAS).

The core research objectives are:
- Develop and apply molecular and immunological tools for understanding host-pathogen interactions and predicting clinical disease outbreaks in farmed rainbow trout infected with PRV-3.
- Implement the developed tools and knowledge in design of fish stock management strategies for mitigating production losses related to PRV-3.

Piscine orthoreovirus 3 (PRV-3) was first diagnosed in Denmark in relation to severe losses on RAS in 2017. A survey revealed that PRV-3 and related disease was widespread particularly in modern freshwater RAS farms. Sea farms stocked with PRV-3 infected fish furthermore experienced quality-degrading discoloration of the fish fillets. Therefore, PRV-3 infection is currently considered a bottleneck for further development of Rainbow trout production in RAS. Diagnosis is hampered by PRV-3 not being culturable in cell cultures.

By application of modern specific and high throughput technologies for detection of viral genes and the fish immune response, the PRVent research will improve understanding of the disease and provide efficient tools for monitoring PRV-3 infections in fish as well as knowledge on how to implement them in counteractive management strategies.

National Institute of Aquatic Resources, DTU Aqua (coordinator)
Danish Aquaculture Association, Denmark
Biomar, Denmark and Norway
AquaPri, Denmark
Løvlund Aps, Denmark
Private Veterinary Practitioners, Denmark
Aquacircle, Denmark

The project is funded by the Ministry of Environment and Food of Denmark through the Green Development and Demonstration Program (GUDP).

Research area: Fish and Shellfish Diseases
Effective start/end date01/07/201930/06/2023


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