Minimizing antibiotic resistance development MINIRESIST

  • Olsen, John Elmerdahl (Project Manager)
  • Hansen, Axel Jacob Kornerup (Project Participant)
  • Guardabassi, Luca (Project Participant)
  • Nielsen, Jens-Peter (Project Participant)
  • Nielsen, Søren Saxmose (Project Participant)
  • Toft, Nils (Project Participant)
  • Angen, Øystein (Project Participant)
  • Madsen, Henrik (Project Participant)
  • Christiansen, Lasse Engbo (Project Participant)
  • Bækbo, Poul (Project Participant)
  • Andreasen, Margit (Project Participant)
  • Matthews, Louise (Project Participant)
  • Schwarz, Stefan (Project Participant)

    Project Details


    The overall objective is to minimize resistance development in the intestinal flora of pigs
    following antibiotic treatment. The project has the following specific objectives:
    - To investigate the influence of antibiotic treatment regimes on the efficacy of treatment, the
    development and spread of resistant bacteria and on the load of resistant bacteria in the intestine
    at the point of slaughter.
    - To investigate the underlying kinetics of selection of resistant bacteria and the spread of
    resistance genes between bacteria in the intestine.
    - To investigate the association between the load of resistant bacteria in the intestine at the
    time of slaughter and the load on the carcasses after slaughter.
    - To develop and validate a comprehensive mathematical model for resistance development
    associated with the use of antibiotics in pig production.
    - To formulate improved treatment regimes using the mathematical model.
    Effective start/end date11/01/200114/12/2013


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