Liquid handling in micro chemical analysis systems

  • Blankenstein, Gert (Project Manager)
  • Branebjerg, Jens (Project Participant)
  • Nielsen, Claus Rye (Project Participant)
  • Larsen, Ulrik Darling (Project Participant)
  • Hoppe, Karsten (Project Participant)

    Project Details


    Liquid handling systems have been developed that contain pumps, switching valves, filters and mixers. These microsystems have a number of advantages over conventional systems: the problem of external interconnections is avoided, consumption of reagents is drastically reduced, and the mixing of reagents is highly predictable, reproducible, and fast. The main effort in 1996 was to improve fluidic interconnections in microsystems. It is important to connect external liquids and pneumatically controlled pumps and valves in the micro system without any leakage at the liquid inlets. Several solutions have been developed and the final solution consists of adding a second glass plate that has been machined and bonded to the sandwich that now consists of glass/silicon/glass. Fluidic channels and feed-through connections are etched through the 500 mm thick glass plate. This process is based on unique etching techniques developed in this project. By making the feed-through connections and fluidic channels in the glass plate and bonding it hermetically to silicon, all inlets of the system are equally distributed over the microsystem surface. Each inlet is interconnected by a tube and individually sealed. This concept has also made it possible to integrate an optical patch in the system in which optical absorption measurements can be done inside the liquid channels in the microsystems.
    Future work will focus on improvements of the liquid handling system and research on chemical reactions in these systems.
    Effective start/end date01/01/1996 → …