Lipases in Organic Synthesis 2

  • Kelstrup, Ebbe (Project Manager)

    Project Details

    Description

    Running tests of the usefulness of industrial lipases in organic synthesis.
    Resolution of Cyclic Carboxylic Acids using Candida antarctica Lipase B CALB) as a catalyst:
    Resolution of 6- and 5-ring O, N, and S heterocyclic carboxylic acids gave mixed results. Thiolane-2-carboxylic acid was obtained in 88% ee at 50% conversion as the most favorable case.
    Resolution of Alcohols using CALB:
    A range of chiral primary alcohols were investigated. In all cases, poor enantioselectivity was observed.
    StatusActive
    Effective start/end date01/01/1998 → …