Project Details
Description
Running tests of the usefulness of industrial lipases in organic synthesis.
Resolution of Cyclic Carboxylic Acids using Candida antarctica Lipase B CALB) as a catalyst:
Resolution of 6- and 5-ring O, N, and S heterocyclic carboxylic acids gave mixed results. Thiolane-2-carboxylic acid was obtained in 88% ee at 50% conversion as the most favorable case.
Resolution of Alcohols using CALB:
A range of chiral primary alcohols were investigated. In all cases, poor enantioselectivity was observed.
Resolution of Cyclic Carboxylic Acids using Candida antarctica Lipase B CALB) as a catalyst:
Resolution of 6- and 5-ring O, N, and S heterocyclic carboxylic acids gave mixed results. Thiolane-2-carboxylic acid was obtained in 88% ee at 50% conversion as the most favorable case.
Resolution of Alcohols using CALB:
A range of chiral primary alcohols were investigated. In all cases, poor enantioselectivity was observed.
| Status | Active |
|---|---|
| Effective start/end date | 01/01/1998 → … |
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