Involvement of cell-cell communication in the pathogenesis of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis

The basic assumption behind the present research proposal is that chemically mediated cell to cell communication exists among bacteria which infect the respiratory tracts of cystic fibrosis (CF) patients. Communication systems enable the bacteria to coordinate and organize their efforts and exhibit cooperative behavioral patterns. This is fundamental to the interaction of bacteria with each other and particularly the higher organism. Based on an increased knowledge of bacterial communication new approaches to effective therapy of CF patients are considered.