Investigations of the substrate specificity of protein tyrosine phosphatases

Protein tyrosine phosphatases are critical elements in the regulation of
signal transduction pathways in living organisms and their unregulated
occurrence are related to diverse pathological events such as diabetes, cancer and immune deficiency. A vast amount of crystallographic and kinetic data have provided an insight in the catalytic mechanism of these enzymes, but questions regarding the mechanisms determining substrate recognition on a molecular level remain to be answered. It is exactly this area which we will investigate by means of theoretical,
computational and experimental methods.