Inflammatory pathways in Inflammatory Bowel Disease and Colorectal Cancer.

  • Vogel, Ulla Birgitte (Project Manager)
  • Østergaard, Mette (Project Participant)
  • Krarup, Henrik (Project Participant)
  • Ernst, Anja (Project Participant)
  • Christensen, Jane (Project Participant)
  • Tjønneland, Anne (Project Participant)

Project Details

Description

CRC and IBD are two large disease entities localised to the intestine. IBD are chronic inflammatory diseases; ulcerative colitis (UC) and Crohns disease (CD) constitutes the majority of the cases. CRC and IBD has great impact on the population morbidity and mortality (CRC) with increasing prevalence.
IBD and CRC are complex diseases; they result from complex interactions between environmental and genetic factors, and the contribution from each gene may be limited and vary between e.g. populations depending on the environmental strain.
IBD is one of the disposing factors leading to CRC and the risk has been shown to depend on the severity of the inflammation burden. Knowledge on the inflammatory pathways leading to IBD may therefore help understanding the pathogenesis of CRC.
The aim of the study is to identify alterations in the intestinal immune responds associated with Inflammatory Bowel Disease (IBD) and Colorectal Cancer (CRC).
We will investigate gene variants in the form of single nucleotide polymorphisms (SNPs) and global gene expression.
StatusFinished
Effective start/end date01/01/200901/12/2012