Project Details


The main objective of the project is to find out the links between infections and autoimmune diseases. INTRICATE examines the connection between specific bacterial infections and the autoimmune disease “Systemic Vasculitis”. DTU Food contributes to the part of the project where it is investigated whether genetic variation in the bacterial Type 1 fimbrial adhesin FimH influences bacterial uptake and pathogenesis. We are specifically working on making mutations in FimH and on creating fusion proteins, which by means of fluorescent markers will make it possible to detect invading bacteria in mammalian cell lines.
Project financing:
INTRICATE is funded by the European Commission under the 7th Framework Programme.
Effective start/end date01/11/201031/10/2013

Collaborative partners

  • Technical University of Denmark (lead)
  • Max Planck Institute (Project partner)
  • Mayo Clinic College of Medicine and Science (Project partner)
  • Hycult Biotechnology b.v. (Project partner)
  • University of Cambridge (Project partner)
  • EMC Microcollections GmbH (Project partner)
  • University of Groningen (Project partner)
  • University Clinic of Bonn (Project partner)
  • Stanford University (Project partner)
  • Medical University of Vienna (Project partner)


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