ESOTRAC, a 5-year research program bringing together engineers and physicians, aims to significantly improve the detection of early-stage esophageal cancer. The interdisciplinary, 5-country research team will develop an innovative endoscope that combines sensing of pathophysiological tissue signatures resolved by multi-spectral optoacoustic (photoacoustic) tomography (MSOT) with morphological disease signatures provided by optical coherence tomography (OCT).