Gluten and celiac disease – a specific food-disease association

  • Madsen, Charlotte Bernhard (Project Manager)

Project Details

Description

Celiac disease (CD) is a chronic disorder with autoimmune characteristics caused by the ingestion of gluten (wheat, rye, barley). The relevance of the project is provided by the recognition that CD is a common disease affecting 0.3-2 % of Caucasians. The project will establish the basis for an oral enzyme-based strategy for management of CD. An in vitro test platform addressing enzyme efficiency, stability and safety will identify safe enzymes with the potential of ‘detoxifying' at low dose an average gluten intake. Preclinical studies in rats will be performed on selected enzymes (oral intake). A ‘proof-of-principle' clinical study will be initiated using gluten treated ex vivo with safe enzymes. Simultaneously, the risks, benefits and technical challenges related to oral application of the selected enzyme(s) will be investigated. The impact of dietary intervention on the health related quality of life will be assessed in children with CD, and in children and adolescents with type 1 diabetes and CD. A significant improvement of the health related quality of life of patients with CD is anticipated. The project will have an impact on Danish industrial enzyme producers, biotech and food industry.

Tasks for DTU Dept. of Toxicology
Our part of the project is to investigate the in vivo efficacy of selected enzymes on gluten degradation and the possible formation of immunogenic fractions. In addition we will conduct a state-of-the art 90 days toxicological study in rats on the selected enzyme.
StatusFinished
Effective start/end date01/04/200930/06/2014