From BACterial Hosts for production of Bioactive phenolics from bERRY fruits to products

  • Förster, Jochen (Project Coordinator)
  • Dudnik, Alexey (Project Manager)
  • Gaspar, Paula (Project Participant)
  • Stahlhut, Steen Gustav (Project Participant)
  • Ögmundarson, Ólafur (Project Participant)
  • Rasmussen, Birte Kastrup (Project Manager)
  • Lohmann, Ricarda (Project Manager)

Project Details

Description

In the era of increased environmental and health awareness new ways are being explored how to fully exploit to this day unrivalled natural resources with renewable bio-production. These new production methods will generate a sustainable pipeline of environmentally-friendly methods to enable production of pharma and agrochemical products with bioactive properties from berry fruits.
This project stands out in bringing together the most recent technologies within the framework of systems metabolic engineering to develop the next-generation bacterial cell factories for the production of plant phenolics, and in applying it to phenolic compounds from cultivated, wild and underutilized species of berries - recognized for their antioxidant, health-promoting and functional properties and applied across applications as diverse as aromas, colours, nutraceuticals and medicines.
BacHBERRY (From BACterial Hosts for production of Bioactive phenolics from bERRY fruits to products) sets out over a three year periode to develop a portfolio of sustainable methodologies to mine the potential of the untapped biodiversity of the bioactive phenolic compounds in an extensive collection of berry species. Full exploitation of this unrivalled natural resource requires an integrated and comprehensive effort from bioprospecting in berries using SMART high-throughput screens for the valorisation of phenolic bioactivities aligned with their identification using cutting edge analytics and subsequent elucidation of their biosynthetic pathways. This knowledge will facilitate metabolic engineering of suitable bacterial hosts for high-value phenolics production in scalable fermentation bioprocesses, ultimately serving as commercial production platforms.
AcronymBacHBERRY
StatusFinished
Effective start/end date01/11/201331/10/2016

Keywords

  • High-value plant metabolites
  • Bioprospecting
  • Bacterial Cell Factories
  • Biosustainable chemical production
  • Phenolics

Research Output

  • 2 Journal article

Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli

Stahlhut, S. G., Siedler, S., Malla, S., Harrison, S. J., Maury, J., Neves, A. R. & Förster, J., 2015, In : Metabolic Engineering. 31, p. 84-93 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
461 Downloads (Pure)

Highly Active and Specific Tyrosine Ammonia-Lyases from Diverse Origins Enable Enhanced Production of Aromatic Compounds in Bacteria and Saccharomyces cerevisiae

Jendresen, C. B., Stahlhut, S. G., Li, M., Gaspar, P., Siedler, S., Förster, J., Maury, J., Borodina, I. & Nielsen, A. T., 2015, In : Applied and Environmental Microbiology. 81, 13, p. 4458-4476 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
629 Downloads (Pure)

Activities

  • 6 Participating in or organising a conference
  • 1 Participating in or organising workshops, courses, seminars etc.
  • 1 Conference presentations

3rd Annual CRISPR Precision Genome Editing Congress Boston

Alexey Dudnik (Participant)

21 Feb 201723 Feb 2017

Activity: Attending an eventParticipating in or organising a conference

Bacterial hosts for production of bioactive phenolics from berry fruits (BacHBerry): a strawberry in a pill?

Alexey Dudnik (Guest lecturer)

21 Sep 2017

Activity: Talks and presentationsConference presentations

International Conference on CRISPR Technologies

Alexey Dudnik (Participant)

4 Dec 20176 Dec 2017

Activity: Attending an eventParticipating in or organising a conference

File