Endocrine disruptors: Exploring new endpoints, low dose- and mixture-effects in humans, aquatic wildlife and laboratory animals

EDEN was a very large EU-funded project, which aimed to address major knowledge gaps in relation to whether exposure to endocrine disrupting chemicals (EDC) from the environment plays any causal role for male reproductive health.

The research activities in EDEN were organised in four themes working with:

Exposure assessment of complex EDC mixtures in human and fish tissues
Mechanism of EDC action, novel endpoints and biomarkers
Indicators of impaired reproductive function in European men
Low-dose and mixture effects of EDC, providing empirical evidence and exploring implications for regulation and testing.

The National Food Institute, Technical University of Denmark had a major role in the work in theme 4. In this theme, we performed experimental studies of low dose and mixture effects in laboratory animals. In addition, we contributed to exploring the implications for regulatory testing of chemicals.