Coping with Anthelmintic Resistance in ruminants

The objective is to provide sustainable strategies for Coping with Anthelmintic RESistance in ruminants (CARES). We will investigate:
- methods of early and sensitive detection of AR (WP1)
- the use of plants with AH properties as a promising alternative control option (WP2)
- reversion of AR by plant compounds (WP3)
- the combination of bioactive forages with best-use options, e.g. grazing management and TST on-farm (WP4) Expected results and their exploitation
Our collaboration will yield novel synergies which can dramatically improve the sustainability of parasite control and livestock production, and result in:
- better AR detection for early intervention and decreased spread of AR and consequent economic losses;
- guidelines for use of AH plants in GIN control, including against AR nematodes;
- better/reduced use of existing drugs, reversion of existing AR, and reduced chemical residues in food;
- evidence-based advice for herd management for GIN control and for limiting AR;
- on-farm demonstration of novel, sustainable and economical means of GIN control;
- and international and national dissemination of findings.
The aims of the project, the expected results and their exploitation agree closely with the EMIDA-aims of new tools for detection of AR and effective GIN control by herd management and alternative medication while limiting AR.
The success and the performance of the project relies on several synergistic aspects:
(i) its novelty in the context of sustainable agronomic systems
(ii) the use of complementary approaches ranging from molecular tools and field management practices and
(iii) the recent development of novel cellular and molecular tools that are available in the laboratories involved in the project, to study resistance mechanisms in nematodes. The extensive experience of most partners with field work and on-farm contacts will secure exploitation and successful dissemination to the livestock industry.