Project Details
Description
In the EU project Contamed, DTU FOOD conducts extended developmental toxicity rat studies investigating the possible role of mixtures of 12-14 estrogens, anti-androgens and other classes of EDCs in producing long-lasting delayed adverse reproductive effects at environmentally relevant levels. The endpoints assessed cover effects on male and female offspring during the postnatal development of the pups as well as long-lasting effects in adult offspring, i.e., anogenital distance, nipple retention, mammary gland development, histopathology and gene expression in selected reproductive organs, puberty, malformations of reproductive organs (hypospadias), oestrus cycling, semen quality and sexual dimorphic behaviour. DTU FOOD will also conduct In vitro assays and is responsible for the H295R assay
Financial support from the EU seventh framework programme (grant agreement no.: 212502) and Danish Environmental Protection Agency.
Financial support from the EU seventh framework programme (grant agreement no.: 212502) and Danish Environmental Protection Agency.
| Status | Finished |
|---|---|
| Effective start/end date | 01/05/2008 → 01/11/2012 |
Collaborative partners
- Technical University of Denmark (lead)
- Universidad De Granada (Project partner)
- Faust und Backhaus Environmental Consulting GBR (Project partner)
- University College London (Project partner)
- Erasmus University Medical Center (Project partner)
- University of Sussex (Project partner)
- GREEN Tox (Project partner)
- University of Bristol (Project partner)
- University of London (Project partner)
Keywords
- mixtures
- endocrine disrupters
- human reproductive health
- developmental toxicity
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.