COMPRENDO. Comparative research on endocrine disrupters - phytogenetic approach and common principles focussing on androgenic/antiandrogenic compounds.

  • Kusk, Kresten Ole (Project Manager)
  • Wollenberger, Leah (Project Participant)
  • Hedberg, Camilla Berg (Project Participant)

    Project Details

    Description

    Comprendo is an interdisciplinary, integrated approach addresses endocrine disruption in human and wildlife species, focused on androgenic/ antiandrogenic compounds (AACs). The project will identify human and environmental exposures to AACs. A variety of human-relevant models (cell lines, tissues, rodents) and wildlife species (amphibians, fish, echinoderms, crustaceans, molluscs) will be exposed to 13 chemicals and various environmental samples to develop new biological effect measures, including a molecular screen for genomic AAC effects. Common principles of AAC action will be identified and new models for the extrapolation on human health developed. Lab cultures of suitable invertebrates will be established and their baseline endocrinology analysed, facilitating the use of these species as standard test organisms. Finally, an evaluation of the risk originating from AACs for humans and wildlife will be performed.
    AcronymCOMPRENDO
    StatusFinished
    Effective start/end date01/10/200230/09/2005

    Collaborative partners

    • Technical University of Denmark (lead)
    • University of Milan (Project partner)
    • Hatherly Laboratories (Project partner)
    • University of Gdańsk (Project partner)
    • Johann Wolfgang Goethe-Universität Frankfurt (Project partner)
    • Bureau de recherches géologiques et minières (Project partner)
    • CSIC (Project partner)
    • University of Insubria (Project partner)
    • Universitätsklinikum Bonn (Project partner)
    • Lund University (Project partner)
    • University of Ioannina (Project partner)
    • Forschungsverbund Berlin e.V. (Project partner)
    • Brunel University London (Project partner)
    • Technical University of Denmark (Project partner)

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