The results from a pilot-study in our labs, indicates that it possible to modulate the composition of the intestinal microbiota by emulsifying fat in milk phospholipids (MPL), instead of using soy-lecithin that is normally used f ex. in infant formulas. In the study, we mimicked the intestinal colonization occurring at birth, by transferring germ-free mice out of the sterile environment and into cages containing faeces from a normal mouse, while they were given the emulsions for three week. The results show that the numbers of bacteria from the phylum Firmicutes decreased in the colon lumen in mice that were given the MPL-based emulsions (fig. 1 below) while Bacteriodetes was not affected. Since obesity-development have been linked to increased ratio between Firmicutes and Bacteriodetes in the colon, the result indicates that it could be possible to reduce the risk of developing obesity later in life by exchanging soy-lecithin with MPL in infant formulas. To elucidate this possibility, we want to perform three studies in which we will validate the results from the pilot-study in a bigger study, determine the mechanism that is explaining the effect on microbial composition and determine whether this effect is persistent also after intake of the emulsion have stopped and whether it actually reduce the risk of developing obesity and metabolic diseases later in life.
|Effective start/end date||02/01/2012 → 31/12/2015|
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