C.1 Process synthesis with thermodynamic and physical insights

  • Gani, Rafiqul (Project Manager)
  • Hostrup, Martin (Project Participant)
  • Takano, Kiyoteru (Project Participant)
  • Grossmann, Ignacio (Project Participant)
  • Kravanja, Zdravko (Project Participant)

Project Details


Similar synthesis (flowsheet generation) algorithms are also being developed for pharmaceutical and biochemical processes. Since, compared to the chemical processes, these processes are considerably different, the synthesis algorithm needs modifications. This is primarily because many of the needed properties may not be available. Therefore, new definitions of relationships between separation techniques and process design independent of the properties need to be developed. It has been possible to graphically generate feasible process flowsheets together with the corresponding conditions of operation through the use of solubility diagrams of mixtures with electrolyte systems. These methods are now being converted into computer aided synthesis and design techniques.
Research on hybrid separation processes has been started. The principle of hybridisation has been defined as the use of two or more separation techniques at their highest separation efficiencies in order to perform a desirable separation. As an example, consider the separation of aqueous azeotropic mixtures. By conventional distillation alone it is not possible to obtain pure products because of the azeotrope. However, for those azeotropes that are at the low concentration range of water, pervaporation is highly efficient to remove the last amounts of water (starting at the azeotropic point and ending at the pure product). The objective of the project is to develop computer aided synthesis and design techniques for generation of hybrid separation schemes that are energy efficient and environmentally benign. This project is funded by the European Union and has partners from UK, Belgium and Greece.
Effective start/end date01/05/1997 → …