• Søltofts Plads, 223, 208

    2800 Kgs. Lyngby

    Denmark

19972022
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Research Output 2001 2020

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Journal article
2020

The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance

Mattos, E. C., Silva, L. P., Valero, C., de Castro, P. A., Dos Reis, T. F., Ribeiro, L. F. C., Marten, M. R., Silva-Rocha, R., Westmann, C., da Silva, C. H. T. D. P., Taft, C. A., Al-Furaiji, N., Bromley, M., Mortensen, U. H., Benz, J. P., Brown, N. A. & Goldman, G. H., 2020, In : mBio. 11, 1, 23 p., e02962-19.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2019
132 Downloads (Pure)

Cpf1 enables fast and efficient genome editing in Aspergilli

Garcia Vanegas, K., Jarczynska, Z. D., Strucko, T. & Mortensen, U. H., 2019, In : Fungal Biology and Biotechnology. 6, 6, 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2018
300 Downloads (Pure)

Efficient Oligo nucleotide mediated CRISPR-Cas9 Gene Editing in Aspergilli

Nødvig, C. S., Hoof, J. B., Kogle, M. E., Jarczynska, Z. D., Lehmbeck, J., Klitgaard, D. K. & Mortensen, U. H., 2018, In : Fungal Genetics and Biology. 115, p. 78-89

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
270 Downloads (Pure)

Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans

Frandsen, R. J. N., Khorsand-Jamal, P., Kongstad, K. T., Nafisi, M., Kannangara, R. M., Stærk, D., Okkels, F. T., Binderup, K., Madsen, B., Møller, B. L., Thrane, U. & Mortensen, U. H., 2018, In : Scientific Reports. 8, 1

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
156 Downloads (Pure)

Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae 

Garcia Vanegas, K., Larsen, A. B., Eichenberger, M., Fischer, D., Mortensen, U. H. & Naesby, M., 2018, In : Microbial Cell Factories. 17, 10 p., 107.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
227 Downloads (Pure)

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
101 Downloads (Pure)

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kuo, A., Bowyer, P., Matsuda, Y., Mondo, S., Lyhne, E. K., Kogle, M. E., Clum, A., Lipzen, A., Salamov, A., Ngan, C. Y., Daum, C., Chiniquy, J., Barry, K., LaButti, K., Haridas, S. & 7 others, Simmons, B. A., Magnuson, J. K., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E753-E761

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
219 Downloads (Pure)

Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I. & Larsen, T. O., 2018, In : Nature Communications. 9, 1, 10 p., 2587 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
328 Downloads (Pure)

On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2017
265 Downloads (Pure)

CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast

Strucko, T., Buron, L. D., Jarczynska, Z. D., Nødvig, C. S., Mølgaard, L., Halkier, B. A. & Mortensen, U. H., 2017, In : Scientific Reports. 7, 12 p., 41431.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
142 Downloads (Pure)

Effects of Dissolved Oxygen Concentration and Iron Addition on Immediate-early Gene Expression of Magnetospirillum gryphiswaldense MSR-1

Zhuang, S., Anyaogu, D. C., Kasama, T., Workman, M., Mortensen, U. H. & Hobley, T. J., 2017, In : FEMS Microbiology Letters. 364, 11, 21 p., fnx079.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing

Weber, J., Valiante, V., Nødvig, C. S., Mattern, D. J., Slotkowski, R. A., Mortensen, U. H. & Brakhage, A. A., 2017, In : A C S Synthetic Biology. 6, 1, p. 62–68

Research output: Contribution to journalJournal articleResearchpeer-review

247 Downloads (Pure)

Gene expression plasticity across hosts of an invasive scale insect species

Christodoulides, N., Van Dam, A., Peterson, D. A., Frandsen, R. J. N., Mortensen, U. H., Petersen, B., Rasmussen, S., Normark, B. B. & Hardy, N. B., 2017, In : P L o S One. 12, 5, 13 p., e0176956.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
323 Downloads (Pure)

Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9

Nielsen, M. L., Petersen, T. I., Rasmussen, K. B., Thrane, U., Hoof, J. B., Larsen, T. O. & Mortensen, U. H., 2017, In : P L o S One. 12, 1, 9 p., e0169712.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
279 Downloads (Pure)

Genome Sequence of Talaromyces atroroseus, Which Produces Red Colorants for the Food Industry

Thrane, U., Rasmussen, K. B., Petersen, B., Rasmussen, S., Sicheritz-Pontén, T. & Mortensen, U. H., 2017, In : Genome Announcements. 5, 9, 2 p., e01736-16.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
329 Downloads (Pure)

SWITCH: a dynamic CRISPR tool for genome engineering and metabolic pathway control for cell factory construction in Saccharomyces cerevisiae

Garcia Vanegas, K., Lehka, B. J. & Mortensen, U. H., 2017, In : Microbial Cell Factories. 16, 25, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Synthesis of C-Glucosylated Octaketide Anthraquinones in Nicotiana benthamiana by Using a Multispecies-Based Biosynthetic Pathway

Andersen-Ranberg, J., Kongstad, K. T., Nafisi, M., Stærk, D., Okkels, F. T., Mortensen, U. H., Møller, B. L., Frandsen, R. J. N. & Kannangara, R., 2017, In : Chembiochem. 18, 19, p. 1893-1897

Research output: Contribution to journalJournal articleResearchpeer-review

2016
319 Downloads (Pure)

Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper

Meyer, V., Andersen, M. R., Brakhage, A. A., Braus, G. H., Caddick, M. X., Cairns, T. C., de Vries, R. P., Haarmann, T., Hansen, K., Hertz-Fowler, C., Krappmann, S., Mortensen, U. H., Peñalva, M. A., Ram, A. F. J. & Head, R. M., 2016, In : Fungal Biology and Biotechnology. 3, 1, 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

High-resolution kinetics and modeling of hydrogen peroxide degradation in live cells

Altintas, A., Davidsen, K., Garde, C., Mortensen, U. H., Brasen, J. C., Sams, T. & Workman, C., 2016, In : Free Radical Biology & Medicine. 101, p. 143–153

Research output: Contribution to journalJournal articleResearchpeer-review

295 Downloads (Pure)

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

Nielsen, M. L., Petersen, T. I., Petersen, L. M., Mortensen, U. H., Andersen, M. R., Hoof, J. B. & Larsen, T. O., 2016, In : P L o S One. 11, 8, 18 p., e0161199.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
179 Downloads (Pure)

Quantification of oxidative stress phenotypes based on high-throughput growth profiling of protein kinase and phosphatase knockouts

Altıntaş, A., Martini, J., Mortensen, U. H. & Workman, C. T., 2016, In : FEMS Yeast Research. 16, 1, 15 p., fov101.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
127 Downloads (Pure)

SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination

Silva, S., Altmannova, V., Eckert-Boulet, N., Kolesar, P., Gallina, I., Hang, L., Chun, I., Arneric, M., Zhao, X., Buron, L. D., Mortensen, U. H., Krejci, L. & Lisby, M., 2016, In : D N A Repair. 42, p. 11-25 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2015
391 Downloads (Pure)

A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi

Nødvig, C. S., Nielsen, J. B., Kogle, M. E. & Mortensen, U. H., 2015, In : P L o S One. 10, 7, 18 p., e0133085.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
262 Downloads (Pure)

Benchmarking two commonly used Saccharomyces cerevisiae strains for heterologous vanillin-β-glucoside production

Strucko, T., Magdenoska, O. & Mortensen, U. H., 2015, In : Metabolic Engineering Communications. 2, p. 99-108 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Characterization of four new antifungal yanuthones from Aspergillus niger

Petersen, L. M., Holm, D. K., Knudsen, P. B., Nielsen, K. F., Gotfredsen, C. H., Mortensen, U. H. & Larsen, T. O., 2015, In : The Journal of Antibiotics. 68, p. 201-205 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

554 Downloads (Pure)

Heterologous production of fungal secondary metabolites in Aspergilli

Anyaogu, D. C. & Mortensen, U. H., 2015, In : Frontiers in Microbiology. 6, 6 p., 77.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Investigation of a 6-MSA Synthase Gene Cluster in Aspergillus aculeatus Reveals 6-MSA-derived Aculinic Acid, Aculins A-B and Epi-Aculin A

Petersen, L. M., Holm, D. K., Gotfredsen, C. H., Mortensen, U. H. & Larsen, T. O., 2015, In : Chembiochem. 16, 15, p. 2200-2204 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Manipulating the glycosylation pathway in bacterial and lower eukaryotes for production of therapeutic proteins

Anyaogu, D. C. & Mortensen, U. H., 2015, In : Current Opinion in Biotechnology. 36, p. 122-128 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2014
283 Downloads (Pure)

A novel platform for heterologous gene expression in Trichoderma reesei (Teleomorph Hypocrea jecorina)

Jørgensen, M. S., Skovlund, D. A., Johannesen, P. F. & Mortensen, U. H., 2014, In : Microbial Cell Factories. 13, 1, p. 33

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
473 Downloads (Pure)

A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, A. M., Kildegaard, H. F., Petersen, M. B. K., Rank, J., Hansen, B. G., Andersen, M. R. & Mortensen, U. H., 2014, In : P L o S One. 9, 5, 10 p., e96693.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
1256 Downloads (Pure)

EasyClone: method for iterative chromosomal integration of multiple genes in Saccharomyces cerevisiae

Jensen, N. B., Strucko, T., Kildegaard, K. R., David, F., Maury, J., Mortensen, U. H., Förster, J., Nielsen, J. & Borodina, I., 2014, In : F E M S Yeast Research. 14, 2, p. 238–248

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
561 Downloads (Pure)

Molecular and Chemical Characterization of the Biosynthesis of the 6-MSA-Derived Meroterpenoid Yanuthone D in Aspergillus niger.

Holm, D. K., Petersen, L. M., Klitgaard, A., Knudsen, P. B., Jarczynska, Z. D., Nielsen, K. F., Gotfredsen, C. H., Larsen, T. O. & Mortensen, U. H., 2014, In : Chemistry & Biology. 21, 4, p. 519-529 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2013

Accurate prediction of secondary metabolite gene clusters in filamentous fungi.

Andersen, M. R., Nielsen, J. B., Klitgaard, A., Petersen, L. M., Zachariasen, M., Hansen, T. J., Holberg Blicher, L., Gotfredsen, C. H., Larsen, T. O., Nielsen, K. F. & Mortensen, U. H., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. E99-E107

Research output: Contribution to journalJournal articleResearchpeer-review

415 Downloads (Pure)

Aspergillus nidulans Synthesize Insect Juvenile Hormones upon Expression of a Heterologous Regulatory Protein and in Response to Grazing by Drosophila melanogaster Larvae.

Nielsen, M. T., Klejnstrup, M. L., Rohlfs, M., Anyaogu, D. C., Nielsen, J. B., Gotfredsen, C. H., Andersen, M. R., Hansen, B. G., Mortensen, U. H. & Larsen, T. O., 2013, In : PloS one.. 8, 8, 11 p., e73369.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
227 Downloads (Pure)

Expression and functional studies of genes involved in transport and metabolism of glycerol in Pachysolen tannophilus.

Liu, X., Mortensen, U. H. & Workman, M., 2013, In : Microbial Cell Factories. 12, p. 27

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
310 Downloads (Pure)

Heterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach

Nielsen, M. T., Nielsen, J. B., Anyaogu, D. C., Holm, D. K., Nielsen, K. F., Larsen, T. O. & Mortensen, U. H., 2013, In : P L o S One. 8, 8, e72871.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
203 Downloads (Pure)

Reconstruction of the biosynthetic pathway for the core fungal polyketide scaffold rubrofusarin in Saccharomyces cerevisiae

Rugbjerg, P., Naesby, M., Mortensen, U. H. & Frandsen, R. J. N., 2013, In : Microbial Cell Factories. 12, 1, 9 p., 31.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Supercluster takes a walk on the wild side

Nielsen, J. B., Andersen, M. R. & Mortensen, U. H., 2013, In : Trends in Microbiology. 21, 12, p. 617-618

Research output: Contribution to journalJournal articleResearchpeer-review

2012
442 Downloads (Pure)

Genetics of Polyketide Metabolism in Aspergillus nidulans

Klejnstrup, M. L., Frandsen, R. J. N., Holm, D. K., Nielsen, M. T., Mortensen, U. H., Larsen, T. O. & Nielsen, J. B., 2012, In : Metabolites. 2, 1, p. 100-133

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
466 Downloads (Pure)

Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

Hansen, B. G., Mnich, E., Nielsen, K. F., Nielsen, J. B., Nielsen, M. T., Mortensen, U. H., Larsen, T. O. & Patil, K. R., 2012, In : Applied and Environmental Microbiology. 78, 14, p. 4908-4913

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform

Mikkelsen, M. D., Buron, L. D., Salomonsen, B., Olsen, C. E., Hansen, B. G., Mortensen, U. H. & Halkier, B. A., 2012, In : Metabolic Engineering. 14, 2, p. 104-111

Research output: Contribution to journalJournal articleResearchpeer-review

2011
229 Downloads (Pure)

(+)-Geodin from Aspergillus terreus.

Rønnest, M. H., Nielsen, M. T., Leber, B., Mortensen, U. H., Krämer, A., Clausen, M. H., Larsen, T. O. & Harris, P., 2011, In : Acta Crystallographica. Section C: Crystal Structure Communications. 67, Pt 3, p. o125-o128

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
1 Downloads (Pure)

A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans

Nielsen, M. L., Nielsen, J. B., Rank, C., Klejnstrup, M. L., Holm, D. K., Brogaard, K. H., Hansen, B. G., Frisvad, J. C., Larsen, T. O. & Mortensen, U. H., 2011, In : F E M S Microbiology Letters. 321, 2, p. 157-166

Research output: Contribution to journalJournal articleResearchpeer-review

212 Downloads (Pure)

A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi

Hansen, B. G., Genee, H. J., Kaas, C. S., Nielsen, J. B., Regueira, T. B. H., Mortensen, U. H., Frisvad, J. C. & Patil, K. R., 2011, In : B M C Microbiology. 11, 1, p. 202

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes.

Albertsen, L., Chen, Y., Bach, L. S., Rattleff, S., Maury, J., Pedersen, S. B., Nielsen, J. & Mortensen, U. H., 2011, In : Applied and Environmental Microbiology. 77, 3, p. 1033-1040

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum

Regueira, T. U. B., Kildegaard, K. R., Hansen, B. G., Mortensen, U. H., Hertweck, C. & Nielsen, J., 2011, In : Applied and Environmental Microbiology. 77, 9, p. 3035-3043

Research output: Contribution to journalJournal articleResearchpeer-review

271 Downloads (Pure)

PHUSER (Primer Help for USER): a novel tool for USER fusion primer design

Olsen, L. R., Hansen, N. B., Bonde, M., Genee, H. J., Holm, D. M. K., Carlsen, S., Hansen, B. G., Patil, K. R., Mortensen, U. H. & Wernersson, R., 2011, In : Nucleic Acids Research. 39, Suppl. 2, p. W61-W67

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Rumlig organisering af enzymer øger cellefabrikkers effektivitet

Albertsen, L. & Mortensen, U. H., 2011, In : Dansk Kemi. 92, 3, p. 22-25

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Versatile Enzyme Expression and Characterization System for Aspergillus nidulans, with the Penicillium brevicompactum Polyketide Synthase Gene from the Mycophenolic Acid Gene Cluster as a Test Case

Hansen, B. G., Salomonsen, B., Nielsen, M. T., Nielsen, J. B., Hansen, N. B., Nielsen, K. F., Regueira, T. U. B., Nielsen, J., Patil, K. R. & Mortensen, U. H., 2011, In : Applied and Environmental Microbiology. 77, 9, p. 3044-3051

Research output: Contribution to journalJournal articleResearchpeer-review

2010

A versatile selection system for folding competent proteins using genetic complementation in a eukaryotic host

Lyngsø, C., Kjaerulff, S., Muller, S., Bratt, T., Mortensen, U. H. & Dal Degan, F., 2010, In : Protein Science. 19, 3, p. 579-592

Research output: Contribution to journalJournal articleResearchpeer-review