Publications per year
Publications per year
Personal profile
Profile
Gærgenetik og reparation af DNA skader
Ud over at være centerleder for CMB forsker Uffe Mortensen i genreparationer og mekanismerne bag genetisk ustabilitet. Typisk bruger han mikroorgansimer som modelsystemer til at forstå disse komplekse processer med henblik på at kunne udvikle stabile produktionsstammer og til at forstå de molekylære mekanismer, der leder til cancer. Et andet mål i hans forskning er at finde metoder til at manipulere genomer. I mikroorganismer kan dette udnyttes til at skræddersy en organisme til effektivit at lave et interessant produkt, fx en metabolit, der normalt bliver produceret i en plante, eller til at lave definerede mutant biblioteker i en given stamme med henblik på en komplet genetisk kortlægning af en given proces. I fremtiden vil videreudvikling af sådanne metoder kunne bruges medicinsk som genterapi.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Publications
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Genome-wide host-pathway interactions affecting cis-cis-muconic acid production in yeast
Cachera, P., Kurt, N. C., Røpke, A., Strucko, T., Mortensen, U. H. & Jensen, M. K., 2024, In: Metabolic Engineering. 83, p. 75-85Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile18 Downloads (Pure) -
Genomic Analysis of Aspergillus Section Terrei Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation
Theobald, S., Vesth, T. C., Geib, E., Nybo, J. L., Frisvad, J. C., Larsen, T. O., Kuo, A., LaButti, K., Lyhne, E. K., Kjærbølling, I., Ledsgaard, L., Barry, K., Clum, A., Chen, C., Nolan, M., Sandor, L., Lipzen, A., Mondo, S., Pangilinan, J. & Salamov, A. & 15 others, , 2024, In: Journal of Fungi. 10, 7, 17 p., 507.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Downloads (Pure) -
Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii
Strucko, T., Gadar-Lopez, A. E., Frøhling, F. B., Frost, E. T., Iversen, E. F., Olsson, H., Jarczynska, Z. D. & Mortensen, U. H., 2024, In: FEMS Yeast Research. 24, 9 p., foae026.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
A Mad7 System for Genetic Engineering of Filamentous Fungi
Vanegas, K. G., Rendsvig, J. K. H., Jarczynska, Z. D., Cortes, M. V. D. C. B., van Esch, A. P., Morera-Gómez, M., Contesini, F. J. & Mortensen, U. H., 2023, In: Journal of Fungi. 9, 1, 13 p., 16.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile144 Downloads (Pure) -
CRI-SPA: a high-throughput method for systematic genetic editing of yeast libraries
Cachera, P., Olsson, H., Coumou, H., Jensen, M. L., Sánchez, B. J., Strucko, T., van den Broek, M., Daran, J.-M., Jensen, M. K., Sonnenschein, N., Lisby, M. & Mortensen, U. H., 2023, In: Nucleic Acids Research. 51, 17, 14 p., e91.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile49 Downloads (Pure)
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BASF-DTU Maximizing recombinant protein overexpression and expression efficacy prediction
Lund, H. M. D. (PhD Student), Meyer, A. S. (Main Supervisor), Larsen, T. O. (Supervisor), Mortensen, U. H. (Supervisor) & Haefner, S. (Supervisor)
01/02/2024 → 31/01/2027
Project: PhD
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BASF-DTU PhD Secondary metabolite gene clusters
Holm, V. (PhD Student), Mortensen, U. H. (Main Supervisor), Larsen, T. O. (Supervisor), Meyer, A. S. (Supervisor) & Haefner, S. (Supervisor)
01/02/2024 → 31/01/2027
Project: PhD
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Discovery of new fungal enzymes for degradation of thermoset plastics
Jagrelius, R. H. (PhD Student), Mortensen, U. H. (Main Supervisor) & Westh, P. (Supervisor)
01/10/2023 → 30/09/2026
Project: PhD
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Discovery and Production of New Carbohydrate Active Enzymes
Gómez, M. M. (PhD Student), Mortensen, U. H. (Main Supervisor), Jares Contesini, F. (Supervisor), Henrissat, B. P. (Supervisor) & Nørholm, M. (Supervisor)
01/05/2022 → 30/04/2025
Project: PhD
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Engineering feedback regulation for recombinant protein production
Kastberg, L. L. B. (PhD Student), Mortensen, U. H. (Supervisor), Förster, J. (Main Supervisor), Sudarsan, S. (Supervisor), Ceroni, F. (Examiner) & Mattanovich, D. (Examiner)
01/01/2021 → 02/10/2024
Project: PhD
Activities
- 1 Conference presentations
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Adaptive Laboratory Evolution of Saccharomyces cerevisiae Diploid Strains for Mannitol Utilization as a Carbon Source
Porcayo Loza, J. (Speaker) & Mortensen, U. H. (Other)
27 Aug 2017 → 1 Sept 2017Activity: Talks and presentations › Conference presentations
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