Research output per year
Research output per year
Personal profile
Profile
Tilmann Weber is Professor for Natural Products Genome Mining and Associate Scientific Director of the Natural Products Genome Mining group at the Novo Nordisk Foundation Center for Biosustainability of the Technical University of Denmark. His main research interest is focused on deciphering the molecular pathways and engineering the biosynthesis of natural products by combining genetic, biochemical and bioinformatics methods. He is a pioneer in developing software for the automated genome mining (CLUSEAN, antiSMASH, antiSMASH-DB) and analysis of secondary metabolite biosynthetic pathways. His group was able to firstly elucidate the biosynthetic pathways of the elfamycin family of antibiotics and is deeply involved in developing CRISPR-based metabolic engineering tools for actinomycetes.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Activation and identification of a griseusin cluster in streptomyces sp. Ca-256286 by employing transcriptional regulators and multi-omics methods
Beck, C., Gren, T., Ortiz-López, F. J., Jørgensen, T. S., Carretero-Molina, D., Serrano, J. M., Tormo, J. R., Oves-Costales, D., Kontou, E. E., Mohite, O. S., Mingyar, E., Stegmann, E., Genilloud, O. & Weber, T., 2021, In: Molecules. 26, 24 p., 6580.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Downloads (Pure) -
antiSMASH 6.0: improving cluster detection and comparison capabilities
Blin, K., Shaw, S., Kloosterman, A. M., Charlop-Powers, Z., van Wezel, G. P., Medema, M. H. & Weber, T., 2021, In: Nucleic acids research. 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile335 Downloads (Pure) -
A regulator based “semi-targeted” approach to activate silent biosynthetic gene clusters
Mingyar, E., Mühling, L., Kulik, A., Winkler, A., Wibberg, D., Kalinowski, J., Blin, K., Weber, T., Wohlleben, W. & Stegmann, E., 2 Jul 2021, In: International Journal of Molecular Sciences . 22, 14, 14 p., 7567.Research output: Contribution to journal › Journal article › peer-review
Open AccessFile26 Downloads (Pure) -
A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing
Tong, Y., Jørgensen, T. S., Whitford, C. M., Weber, T. & Lee, S. Y., 2021, In: Nature Communications. 12, 1, 11 p., 5206.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile25 Downloads (Pure) -
BiG-FAM: the biosynthetic gene cluster families database
Kautsar, S. A., Blin, K., Shaw, S., Weber, T. & Medema, M. H., 2021, In: Nucleic acids research. 49, D1, p. D490–D497Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile59 Downloads (Pure)
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Diversity and Evolution of bacterial Biosynthetic Gene Clusters
Nielsen, L. J. D., Kovács, Á. T. & Weber, T.
01/01/2022 → 31/12/2024
Project: PhD
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Data-Driven Natural Products Discovery in Soil Microbial Interaction
Nuhamunada, M., Weber, T., Mohite, O. S. & Arumugam, M.
01/09/2021 → 31/08/2024
Project: PhD
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Comparative Genomics of Actinomycetes
Sterndorff, E. B., Weber, T. & Jørgensen, T. S.
01/12/2020 → 30/11/2023
Project: PhD
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Rhythmicity-tuned Secondary Metabolites Production in Actinobacteria
Yang, Z., Ding, L. & Weber, T.
01/12/2020 → 30/11/2023
Project: PhD
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Global genomic analysis of Bacillus and related genera
Song, L., Kovács, Á. T., Weber, T. & Sun, J.
01/11/2020 → 31/10/2023
Project: PhD
Activities
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Editing microbial genomes: CRISPR-Cas9 technologies
Tilmann Weber (Guest lecturer)
20 Oct 2021 → 22 Oct 2021Activity: Talks and presentations › Guest lectures, external teaching and course activities at other universities
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Mining soils for drugs– Microbes as source for novel antibiotics
Tilmann Weber (Invited speaker)
25 Feb 2021Activity: Talks and presentations › Talks and presentations in private or public companies and organisations
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Natural Products Genome Mining: Where do we go from here?
Tilmann Weber (Keynote speaker)
10 Mar 2021Activity: Talks and presentations › Conference presentations
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The Molecular Treasure Hunt - An 'Omics-based Approach to Find New Bioactive Compounds
Tilmann Weber (Invited speaker)
16 Apr 2021Activity: Talks and presentations › Conference presentations
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The Molecular Treasure Hunt- An ‘Omics-based Approachto Find New Bioactive Compounds
Tilmann Weber (Invited speaker)
15 Jul 2021Activity: Talks and presentations › Guest lectures, external teaching and course activities at other universities
Prizes
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Clarivate Highly Cited Researcher 2020
Weber, Tilmann (Recipient), 2020
Prize: Prizes, scholarships, distinctions
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Corrits Akademiske Rejselegat
Weber, Tilmann (Recipient), 12 Feb 2019
Prize: Prizes, scholarships, distinctions
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Guest Professorship at the East China University of Science and Technology, Shanghai, China
Weber, Tilmann (Recipient), 20 Nov 2019
Prize: Prizes, scholarships, distinctions
Press / Media
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Closing ceremony of "Small World Initiative" course at University of Santiago de Compostela, Spain
04/05/2018
1 Media contribution
Press/Media: Press / Media
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Millions for research into antibiotic resistance and better drugs
Tilmann Weber, Pep Charusanti, Sang Yup Lee & Bernhard Palsson
26/01/2017 → 26/12/2017
2 items of Media coverage, 2 Media contributions
Press/Media: Press / Media
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Video and Blog-post / interview at sciencenews.dk on iimena project (NNF Challenge Grant)
24/11/2017
1 item of Media coverage
Press/Media: Press / Media
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Scientists solve 30-year old mystery on how resistance genes spread
Tilmann Weber, Morten Otto Alexander Sommer, Xinglin Jiang, Sang Yup Lee, Mostafa M Hashim Ellabaan, Pep Charusanti, Christian Munck, Kai Blin & Yaojun Tong
15/06/2017
1 Media contribution
Press/Media: Press / Media
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Scientists discover how to make ‘click-on’ antibiotics
Tilmann Weber, Sang Yup Lee & Ewa Maria Musiol-Kroll
04/04/2017
1 Media contribution
Press/Media: Press / Media