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Journal article
2020

A comparative genomics study of 23 Aspergillus species from section Flavi

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kildgaard, S., Petersen, T. I., Kuo, A., Sato, A., Lyhne, E. K., Kogle, M. E., Wiebenga, A., Kun, R. S., Lubbers, R. J. M., Mäkelä, M. R., Barry, K., Chovatia, M., Clum, A., Daum, C., Haridas, S. & 17 others, He, G., LaButti, K., Lipzen, A., Mondo, S., Pangilinan, J., Riley, R., Salamov, A., Simmons, B. A., Magnuson, J. K., Henrissat, B., Mortensen, U. H., Larsen, T. O., de Vries, R. P., Grigoriev, I. V., Machida, M., Baker, S. E. & Andersen, M. R., 2020, In : Nature Communications. 11, 1, 12 p., 1106.

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Acurin A, a novel hybrid compound, biosynthesized by individually translated PKS- and NRPS-encoding genes in Aspergillus aculeatus

Wolff, P. B., Nielsen, M. L., Slot, J. C., Andersen, L. N., Petersen, L. M., Isbrandt, T., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2020, In : Fungal Genetics and Biology. 139, 10 p., 103378.

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Tenuazonic acid from Stemphylium loti inhibits the plant plasma membrane H+-ATPase by a mechanism involving the C-terminal regulatory domain

Bjørk, P. K., Rasmussen, S. A., Gjetting, S. K., Havshøi, N. W., Petersen, T. I., Ipsen, J. Ø., Larsen, T. O. & Fuglsang, A. T., 2020, In : New Phytologist. 226, 3, p. 770-784 15 p.

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2019

A-, B- and C-type prymnesins are clade specific compounds and chemotaxonomic markers in Prymnesium parvum

Binzer, S. B., Svenssen, D. K., Daugbjerg, N., Alves-de-Souza, C., Pinto, E., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Harmful Algae. 81, p. 10-17

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Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus

Isbrandt, T., Tolborg, G., Ødum, A. S. R., Workman, M. & Larsen, T. O., 2019, In : Applied Microbiology and Biotechnology. p. 1-8 8 p.

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Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, S., Kiesewalter, H. T., Kovács, R., Frisvad, J. C., Weber, T., Larsen, T. O., Kovács, Á. T. & Ding, L., 2019, In : Synthetic and Systems Biotechnology. 4, 3, p. 142-149 8 p.

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Development of an indirect quantitation method to assess ichthyotoxic b-type prymnesins from prymnesium parvum

Svenssen, D. K., Binzer, S. B., Medić, N., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Toxins. 11, 5, 251.

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Isolation of Methyl Troposulfenin from Phaeobacter inhibens

Phippen, C. B. W., Jørgensen, C. M., Bentzon-Tilia, M., Gotfredsen, C. H., Larsen, T. O., Gram, L. & Sonnenschein, E. C., 2019, In : Journal of Natural Products. 82, 5, p. 1387-1390 4 p.

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Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

Frisvad, J. C., Hubka, V., Ezekiel, C. N., Hong, S. B., Nováková, A., Chen, A. J., Arzanlou, M., Larsen, T. O., Sklenář, F., Mahakarnchanakul, W., Samson, R. A. & Houbraken, J., 2019, In : Studies in Mycology. 93, p. 1-63

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Unique processes yielding pure azaphilones in Talaromyces atroroseus

Tolborg, G., Ødum, A. S. R., Isbrandt, T., Larsen, T. O. & Workman, M., 2019, In : Applied Microbiology and Biotechnology. 11 p.

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Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B

Copmans, D., Kildgaard, S., Rasmussen, S. A., Ślezak, M., Dirkx, N., Partoens, M., Esguerra, C. V., Crawford, A. D., Larsen, T. O. & De Witte, P. A. M., 2019, In : Marine Drugs. 17, 11, 20 p., 607.

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2018

Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020

Kildgaard, S., de Medeiros, L. S., Phillips, E., Gotfredsen, C. H., Frisvad, J. C., Nielsen, K. F., Abreu, L. M. & Larsen, T. O., 2018, In : Journal of Natural Products. 81, 4, p. 785-790 6 p.

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Development of a LC-MS/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters

Krock, B., Tillmann, U., Wen, Y., Hansen, P. J., Larsen, T. O. & Andersen, A. J. C., 2018, In : Toxicon. 155, p. 51-60

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Genetic Characterization of Neosartorin Biosynthesis Provides Insight into Heterodimeric Natural Product Generation

Matsuda, Y., Gotfredsen, C. H. & Larsen, T. O., 2018, In : ORGANIC LETTERS. 20, 22, p. 7194-7200 4 p.

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Identification of the decumbenone biosynthetic gene cluster in Penicilliuum decumbens and the importance for production of calbistrin

Grijseels, S., Pohl, C., Nielsen, J. C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2018, In : Fungal Biology and Biotechnology. 5, 17 p., 18.

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Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

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Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kuo, A., Bowyer, P., Matsuda, Y., Mondo, S., Lyhne, E. K., Kogle, M. E., Clum, A., Lipzen, A., Salamov, A., Ngan, C. Y., Daum, C., Chiniquy, J., Barry, K., LaButti, K., Haridas, S. & 7 others, Simmons, B. A., Magnuson, J. K., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E753-E761

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Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I. & Larsen, T. O., 2018, In : Nature Communications. 9, 1, 10 p., 2587 .

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On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

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Pseudoalteromonas haloplanktis TAC125 produces 4-hydroxybenzoic acid that induces pyroptosis in human A459 lung adenocarcinoma cells

Sannino, F., Sansone, C., Galasso, C., Kildgaard, S., Tedesco, P., Fani, R., Marino, G., de Pascale, D., Ianora, A., Parrilli, E., Larsen, T. O., Romano, G. & Tutino, M. L., 2018, In : Scientific Reports. 8, 1, 10 p., 1190.

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Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei

Frisvad, J. C., Møller, L. L. H., Larsen, T. O., Kumar, R. & Arnau, J., 2018, In : Applied Microbiology and Biotechnology. 102, 22, p. 9481-9515

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Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication

Theobald, S., Vesth, T. C., Rendsvig, J. K., Nielsen, K. F., Riley, R., de Abreu, L. M., Salamov, A., Frisvad, J. C., Larsen, T. O., Andersen, M. R. & Hoof, J. B., 2018, In : Scientific Reports. 8, 12 p., 17957.

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2017

A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

Kildgaard, S., Subko, K., Phillips, E., Goidts, V., de la Cruz, M., Díaz, C., Gotfredsen, C. H., Andersen, B., Frisvad, J. C., Nielsen, K. F. & Larsen, T. O., 2017, In : Marine Drugs. 15, 8, 253.

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Biodiversity of mycobiota throughout the Brazil nut supply chain: From rainforest to consumer

Taniwaki, M. H., Frisvad, J. C., Ferranti, L. S., de Souza Lopes, A., Larsen, T. O., Fungaro, M. H. P. & Iamanaka, B. T., 2017, In : Food Microbiology. 61, p. 14-22 9 p.

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Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, R., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, K. T., Stærk, D., Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, B. L., 2017, In : Nature Communications. 8, 1, 12 p., 1987 .

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Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9

Nielsen, M. L., Petersen, T. I., Rasmussen, K. B., Thrane, U., Hoof, J. B., Larsen, T. O. & Mortensen, U. H., 2017, In : P L o S One. 12, 1, 9 p., e0169712.

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HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger

Andersen, A. J. C., Soman De Medeiros, L., Binzer, S. B., Rasmussen, S. A., Hansen, P. J., Nielsen, K. F., Jørgensen, K. & Larsen, T. O., 2017, In : Marine Drugs. 15, 9, 13 p., 278.

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Karmitoxin: An amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger

Rasmussen, S. A., Binzer, S. B., Hoeck, C., Meier, S., Soman De Medeiros, L., Andersen, N. G., Place, A. D., Nielsen, K. F., Hansen, P. J. & Larsen, T. O., 2017, In : Journal of Natural Products. 80, 5, p. 1287-1293 7 p.

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Physiological characterization of secondary metabolite producing Penicillium cell factories

Grijseels, S., Nielsen, J., Nielsen, J., Larsen, T. O., Frisvad, J. C., Nielsen, K. F., Frandsen, R. J. N. & Workman, M., 2017, In : Fungal Biology and Biotechnology. 4, 8, 12 p.

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2016

Black perithecial pigmentation in Fusarium species is due to the accumulation of 5-deoxybostrycoidin-based melanin

Frandsen, R. J. N., Rasmussen, S. A., Knudsen, P. B., Uhlig, S., Petersen, D., Lysøe, E., Gotfredsen, C. H., Giese, H. & Larsen, T. O., 2016, In : Scientific Reports. 6, 13 p., 26206.

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Chemodiversity of Ladder-Frame Prymnesin Polyethers in Prymnesium parvum

Rasmussen, S. A., Meier, S., Andersen, N. G., Blossom, H. E., Duus, J. Ø., Nielsen, K. F., Hansen, P. J. & Larsen, T. O., 2016, In : Journal of Natural Products. 79, 9, p. 2250-2256 7 p.

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Extrolites of Aspergillus fumigatus and Other Pathogenic Species in Aspergillus Section Fumigati

Frisvad, J. C. & Larsen, T. O., 2016, In : Frontiers in Microbiology. 6, 14 p., 1485.

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566 Downloads (Pure)

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

Nielsen, M. L., Petersen, T. I., Petersen, L. M., Mortensen, U. H., Andersen, M. R., Hoof, J. B. & Larsen, T. O., 2016, In : P L o S One. 11, 8, 18 p., e0161199.

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Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

Baldry, M., Nielsen, A., Bojer, M. S., Zhao, Y., Friberg, C., Ifrah, D., Glasser Heede, N., Larsen, T. O., Frøkiær, H., Frees, D., Zhang, L., Dai, H. & Ingmer, H., 2016, In : P L o S One. 11, 12, 16 p., e0168305.

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2015

Aspiperidine oxide, a piperidine N-oxide from the filamentous fungus Aspergillus indologenus

Petersen, L. M., Kildgaard, S., Jaspars, M. & Larsen, T. O., 2015, In : Tetrahedron Letters. 56, 14, p. 1847-1850 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Characterization of four new antifungal yanuthones from Aspergillus niger

Petersen, L. M., Holm, D. K., Knudsen, P. B., Nielsen, K. F., Gotfredsen, C. H., Mortensen, U. H. & Larsen, T. O., 2015, In : The Journal of Antibiotics. 68, p. 201-205 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chemodiversity in the genus Aspergillus

Frisvad, J. C. & Larsen, T. O., 2015, In : Applied Microbiology and Biotechnology. 99, 19, p. 7859-7877 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp.

de Medeiros, L. S., Abreu, L. M., Nielsen, A., Ingmer, H., Larsen, T. O., Nielsen, K. F. & Rodrigues-Filho, E., 2015, In : Phytochemistry. 111, p. 154-162 9 p.

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Induced sclerotium formation exposes new bioactive metabolites from Aspergillus sclerotiicarbonarius

Petersen, L. M., Frisvad, J. C., Knudsen, P. B., Rohlfs, M., Gotfredsen, C. H. & Larsen, T. O., 2015, In : The Journal of Antibiotics. 68, 10, p. 603-608 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Investigation of a 6-MSA Synthase Gene Cluster in Aspergillus aculeatus Reveals 6-MSA-derived Aculinic Acid, Aculins A-B and Epi-Aculin A

Petersen, L. M., Holm, D. K., Gotfredsen, C. H., Mortensen, U. H. & Larsen, T. O., 2015, In : Chembiochem. 16, 15, p. 2200-2204 5 p.

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The importance of mass spectrometric dereplication in fungal secondary metabolite analysis

Nielsen, K. F. & Larsen, T. O., 2015, In : Frontiers in Microbiology. 6, 15 p., 71.

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2014

Accurate Dereplication of Bioactive Secondary Metabolites from Marine-Derived Fungi by UHPLC-DAD-QTOFMS and a MS/HRMS Library

Kildgaard, S., Mansson, M., Dosen, I., Klitgaard, A., Frisvad, J. C., Larsen, T. O. & Nielsen, K. F., 2014, In : Marine Drugs. 12, p. 3681-3705

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Aggressive dereplication using UHPLC–DAD–QTOF: screening extracts for up to 3000 fungal secondary metabolites

Klitgaard, A., Iversen, A., Andersen, M. R., Larsen, T. O., Frisvad, J. C. & Nielsen, K. F., 2014, In : Analytical and Bioanalytical Chemistry. 406, 7, p. 1933-1943

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Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton

Knudsen, P. B., Hanna, B., Ohl, S., Sellner, L., Zenz, T., Döhner, H., Stilgenbauer, S., Larsen, T. O., Lichter, P. & Seiffert, M., 2014, In : Leukemia. 28, 6, p. 1289-1298

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Dereplication Guided Discovery of Secondary Metabolites of Mixed Biosynthetic Origin from Aspergillus aculeatus

Petersen, L. M., Hoeck, C., Frisvad, J. C., Gotfredsen, C. H. & Larsen, T. O., 2014, In : Molecules. 19, 8, p. 10898-10921 24 p.

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Formation of Sclerotia and Production of Indoloterpenes by Aspergillus niger and Other Species in Section Nigri

Frisvad, J. C., Petersen, L. M., Lyhne, E. K. & Larsen, T. O., 2014, In : PLOS ONE. 9, 4, 11 p., e94857.

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Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins - Sclerotionigrin A and B

Petersen, L. M., Bladt, T. T., Duerr, C., Seiffert, M., Frisvad, J. C., Gotfredsen, C. H. & Larsen, T. O., 2014, In : Molecules. 19, 7, p. 9786-9797 12 p.

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Micropeptins from Microcystis sp. collected in Kabul Reservoir, Israel

Bladt, T. T., Kalifa-Aviv, S., Larsen, T. O. & Carmeli, S., 2014, In : Tetrahedron. 70, 4, p. 936-943

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Molecular and Chemical Characterization of the Biosynthesis of the 6-MSA-Derived Meroterpenoid Yanuthone D in Aspergillus niger.

Holm, D. K., Petersen, L. M., Klitgaard, A., Knudsen, P. B., Jarczynska, Z. D., Nielsen, K. F., Gotfredsen, C. H., Larsen, T. O. & Mortensen, U. H., 2014, In : Chemistry & Biology. 21, 4, p. 519-529 11 p.

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Prymnesium parvum revisited: relationship between allelopathy, ichthyotoxicity, and chemical profiles in 5 strains

Blossom, H. E., Rasmussen, S. A., Andersen, N. G., Larsen, T. O., Nielsen, K. F. & Hansen, P. J., 2014, In : Aquatic Toxicology. 157, p. 159-166 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review