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Research Output

2020

A comparative genomics study of 23 Aspergillus species from section Flavi

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kildgaard, S., Petersen, T. I., Kuo, A., Sato, A., Lyhne, E. K., Kogle, M. E., Wiebenga, A., Kun, R. S., Lubbers, R. J. M., Mäkelä, M. R., Barry, K., Chovatia, M., Clum, A., Daum, C., Haridas, S. & 17 others, He, G., LaButti, K., Lipzen, A., Mondo, S., Pangilinan, J., Riley, R., Salamov, A., Simmons, B. A., Magnuson, J. K., Henrissat, B., Mortensen, U. H., Larsen, T. O., de Vries, R. P., Grigoriev, I. V., Machida, M., Baker, S. E. & Andersen, M. R., 2020, In : Nature Communications. 11, 1, 12 p., 1106.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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55 Downloads (Pure)

Acurin A, a novel hybrid compound, biosynthesized by individually translated PKS- and NRPS-encoding genes in Aspergillus aculeatus

Wolff, P. B., Nielsen, M. L., Slot, J. C., Andersen, L. N., Petersen, L. M., Isbrandt, T., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2020, In : Fungal Genetics and Biology. 139, 10 p., 103378.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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75 Downloads (Pure)

Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides

Guo, Y., Frisvad, J. C. & Larsen, T. O., 2020, In : Metabolites. 10, 6, 13 p., 246.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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7 Downloads (Pure)

Tenuazonic acid from Stemphylium loti inhibits the plant plasma membrane H+-ATPase by a mechanism involving the C-terminal regulatory domain

Bjørk, P. K., Rasmussen, S. A., Gjetting, S. K., Havshøi, N. W., Petersen, T. I., Ipsen, J. Ø., Larsen, T. O. & Fuglsang, A. T., 2020, In : New Phytologist. 226, 3, p. 770-784 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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45 Downloads (Pure)
2019

A-, B- and C-type prymnesins are clade specific compounds and chemotaxonomic markers in Prymnesium parvum

Binzer, S. B., Svenssen, D. K., Daugbjerg, N., Alves-de-Souza, C., Pinto, E., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Harmful Algae. 81, p. 10-17

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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292 Downloads (Pure)

Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus

Isbrandt, T., Tolborg, G., Ødum, A. S. R., Workman, M. & Larsen, T. O., 2019, In : Applied Microbiology and Biotechnology. p. 1-8 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, S., Kiesewalter, H. T., Kovács, R., Frisvad, J. C., Weber, T., Larsen, T. O., Kovács, Á. T. & Ding, L., 2019, In : Synthetic and Systems Biotechnology. 4, 3, p. 142-149 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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215 Downloads (Pure)

Development of an indirect quantitation method to assess ichthyotoxic b-type prymnesins from prymnesium parvum

Svenssen, D. K., Binzer, S. B., Medić, N., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Toxins. 11, 5, 251.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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100 Downloads (Pure)

Isolation of Methyl Troposulfenin from Phaeobacter inhibens

Phippen, C. B. W., Jørgensen, C. M., Bentzon-Tilia, M., Gotfredsen, C. H., Larsen, T. O., Gram, L. & Sonnenschein, E. C., 2019, In : Journal of Natural Products. 82, 5, p. 1387-1390 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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48 Downloads (Pure)

Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

Frisvad, J. C., Hubka, V., Ezekiel, C. N., Hong, S. B., Nováková, A., Chen, A. J., Arzanlou, M., Larsen, T. O., Sklenář, F., Mahakarnchanakul, W., Samson, R. A. & Houbraken, J., 2019, In : Studies in Mycology. 93, p. 1-63

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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313 Downloads (Pure)

Unique processes yielding pure azaphilones in Talaromyces atroroseus

Tolborg, G., Ødum, A. S. R., Isbrandt, T., Larsen, T. O. & Workman, M., 2019, In : Applied Microbiology and Biotechnology. 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B

Copmans, D., Kildgaard, S., Rasmussen, S. A., Ślezak, M., Dirkx, N., Partoens, M., Esguerra, C. V., Crawford, A. D., Larsen, T. O. & De Witte, P. A. M., 2019, In : Marine Drugs. 17, 11, 20 p., 607.

Research output: Contribution to journalJournal articleResearchpeer-review

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68 Downloads (Pure)
2018

Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020

Kildgaard, S., de Medeiros, L. S., Phillips, E., Gotfredsen, C. H., Frisvad, J. C., Nielsen, K. F., Abreu, L. M. & Larsen, T. O., 2018, In : Journal of Natural Products. 81, 4, p. 785-790 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Development of a LC-MS/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters

Krock, B., Tillmann, U., Wen, Y., Hansen, P. J., Larsen, T. O. & Andersen, A. J. C., 2018, In : Toxicon. 155, p. 51-60

Research output: Contribution to journalJournal articleResearchpeer-review

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113 Downloads (Pure)

Friends and Foes -Comparative Genomics of 23 Aspergillus Flavi Species

Kjærbølling, I., Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Kogle, M. E., Lyhne, E. K., Sato, A., Hainaut, M., Drula, E., Henrissat, B., Kuo, A., Salamov, A., Riley, R., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Friends and foes - comparative genomics of 23 Aspergillus Flavi species

Kjærbølling, I., Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Kogle, M. E., Lyhne, E. K., Kuo, A., Salamov, A., Riley, R., Larsen, T. O., Mortensen, U. H., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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158 Downloads (Pure)

Genetic Characterization of Neosartorin Biosynthesis Provides Insight into Heterodimeric Natural Product Generation

Matsuda, Y., Gotfredsen, C. H. & Larsen, T. O., 2018, In : ORGANIC LETTERS. 20, 22, p. 7194-7200 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genomics driven discovery and engineering of fungal polycyclic polyketides

Subko, K., Wolff, P. B., Theobald, S., Frisvad, J. C., Gotfredsen, C. H., Andersen, M. R., Mortensen, U. H. & Larsen, T. O., 2018, p. 68.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

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759 Downloads (Pure)

Identification of the decumbenone biosynthetic gene cluster in Penicilliuum decumbens and the importance for production of calbistrin

Grijseels, S., Pohl, C., Nielsen, J. C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2018, In : Fungal Biology and Biotechnology. 5, 17 p., 18.

Research output: Contribution to journalJournal articleResearchpeer-review

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259 Downloads (Pure)

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

Research output: Contribution to journalJournal articleResearchpeer-review

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325 Downloads (Pure)

In vivo engineering of polyketide synthases

Olsen, K. J. K., Larsen, T. O. & Frandsen, R. J. N., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

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149 Downloads (Pure)

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kuo, A., Bowyer, P., Matsuda, Y., Mondo, S., Lyhne, E. K., Kogle, M. E., Clum, A., Lipzen, A., Salamov, A., Ngan, C. Y., Daum, C., Chiniquy, J., Barry, K., LaButti, K., Haridas, S. & 7 others, Simmons, B. A., Magnuson, J. K., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E753-E761

Research output: Contribution to journalJournal articleResearchpeer-review

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158 Downloads (Pure)

Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I. & Larsen, T. O., 2018, In : Nature Communications. 9, 1, 10 p., 2587 .

Research output: Contribution to journalJournal articleResearchpeer-review

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282 Downloads (Pure)

On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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461 Downloads (Pure)

Pseudoalteromonas haloplanktis TAC125 produces 4-hydroxybenzoic acid that induces pyroptosis in human A459 lung adenocarcinoma cells

Sannino, F., Sansone, C., Galasso, C., Kildgaard, S., Tedesco, P., Fani, R., Marino, G., de Pascale, D., Ianora, A., Parrilli, E., Larsen, T. O., Romano, G. & Tutino, M. L., 2018, In : Scientific Reports. 8, 1, 10 p., 1190.

Research output: Contribution to journalJournal articleResearchpeer-review

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249 Downloads (Pure)

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei

Frisvad, J. C., Møller, L. L. H., Larsen, T. O., Kumar, R. & Arnau, J., 2018, In : Applied Microbiology and Biotechnology. 102, 22, p. 9481-9515

Research output: Contribution to journalJournal articleResearchpeer-review

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324 Downloads (Pure)

Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication

Theobald, S., Vesth, T. C., Rendsvig, J. K., Nielsen, K. F., Riley, R., de Abreu, L. M., Salamov, A., Frisvad, J. C., Larsen, T. O., Andersen, M. R. & Hoof, J. B., 2018, In : Scientific Reports. 8, 12 p., 17957.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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265 Downloads (Pure)
2017

A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

Kildgaard, S., Subko, K., Phillips, E., Goidts, V., de la Cruz, M., Díaz, C., Gotfredsen, C. H., Andersen, B., Frisvad, J. C., Nielsen, K. F. & Larsen, T. O., 2017, In : Marine Drugs. 15, 8, 253.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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323 Downloads (Pure)

Biodiversity of mycobiota throughout the Brazil nut supply chain: From rainforest to consumer

Taniwaki, M. H., Frisvad, J. C., Ferranti, L. S., de Souza Lopes, A., Larsen, T. O., Fungaro, M. H. P. & Iamanaka, B. T., 2017, In : Food Microbiology. 61, p. 14-22 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2 Downloads (Pure)

Biosynthesis of acurin A and B in Aspergillus aculeatus

Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Petersen, T. I., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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299 Downloads (Pure)

Biosynthesis of acurin A and B in Aspergillus aculeatus

Hoof, J. B., Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Petersen, T. I., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

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116 Downloads (Pure)

Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, R., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, K. T., Stærk, D., Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, B. L., 2017, In : Nature Communications. 8, 1, 12 p., 1987 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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351 Downloads (Pure)

Elucidating the biosynthetic pathway of the anticancer secondary metabolite calbistrin in Penicillium decumbens

Grijseels, S., Pohl, C., Wasil, Z., Froslev Nielsen, J. C., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2017. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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178 Downloads (Pure)

Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9

Nielsen, M. L., Petersen, T. I., Rasmussen, K. B., Thrane, U., Hoof, J. B., Larsen, T. O. & Mortensen, U. H., 2017, In : P L o S One. 12, 1, 9 p., e0169712.

Research output: Contribution to journalJournal articleResearchpeer-review

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388 Downloads (Pure)

Genus level analysis of secondary metabolism reveals the origin of Aspergillus hybrid NRPS-PKS gene clusters

Theobald, S., Vesth, T. C., Rasmussen, J. L. N., Kjærbølling, I., Frisvad, J. C., Nielsen, K. F., Larsen, T. O., Grigoriev, I. V., Salamov, A., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2017. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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87 Downloads (Pure)

HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger

Andersen, A. J. C., Soman De Medeiros, L., Binzer, S. B., Rasmussen, S. A., Hansen, P. J., Nielsen, K. F., Jørgensen, K. & Larsen, T. O., 2017, In : Marine Drugs. 15, 9, 13 p., 278.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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305 Downloads (Pure)

Identifying more than 300 Biosynthetic Gene Clusters with Potential Resistance Genes in over 75 Aspergillus species using Resistance Gene-Guided Genome Mining

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Rasmussen, J. L. N., Theobald, S., Grigoriev, I. V., Salamov, A., Larsen, T. O., Mortensen, U. H. & Andersen, M. R., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

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125 Downloads (Pure)

Karmitoxin: An amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger

Rasmussen, S. A., Binzer, S. B., Hoeck, C., Meier, S., Soman De Medeiros, L., Andersen, N. G., Place, A. D., Nielsen, K. F., Hansen, P. J. & Larsen, T. O., 2017, In : Journal of Natural Products. 80, 5, p. 1287-1293 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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302 Downloads (Pure)

Microbial platform for production of aromatic compounds

Skovbjerg, C. A. E., Olsen, K. J. K., Larsen, T. O. & Frandsen, R. J. N., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

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221 Downloads (Pure)

Physiological characterization of secondary metabolite producing Penicillium cell factories

Grijseels, S., Nielsen, J., Nielsen, J., Larsen, T. O., Frisvad, J. C., Nielsen, K. F., Frandsen, R. J. N. & Workman, M., 2017, In : Fungal Biology and Biotechnology. 4, 8, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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486 Downloads (Pure)

What drives speciation? Examination into the evolutionary events of more than 100 Aspergillus species

Rasmussen, J. L. N., Vesth, T. C., Theobald, S., Kjærbølling, I., Frisvad, J. C., Larsen, T. O., Riley, R., Salamov, A., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2017. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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101 Downloads (Pure)
2016

Black perithecial pigmentation in Fusarium species is due to the accumulation of 5-deoxybostrycoidin-based melanin

Frandsen, R. J. N., Rasmussen, S. A., Knudsen, P. B., Uhlig, S., Petersen, D., Lysøe, E., Gotfredsen, C. H., Giese, H. & Larsen, T. O., 2016, In : Scientific Reports. 6, 13 p., 26206.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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379 Downloads (Pure)

Chemical Diversity, Origin, and Analysis of Phycotoxins

Rasmussen, S. A., Andersen, A. J. C., Andersen, N. G., Nielsen, K. F., Hansen, P. J. & Larsen, T. O., 2016, In : Journal of Natural Products. 79, 3, p. 662-673 12 p.

Research output: Contribution to journalReviewResearchpeer-review

Chemodiversity of Ladder-Frame Prymnesin Polyethers in Prymnesium parvum

Rasmussen, S. A., Meier, S., Andersen, N. G., Blossom, H. E., Duus, J. Ø., Nielsen, K. F., Hansen, P. J. & Larsen, T. O., 2016, In : Journal of Natural Products. 79, 9, p. 2250-2256 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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250 Downloads (Pure)

Chemodiversity of the ladder-frame prymnesin polyethers of the fish-killing microalgal Prymnesium parvum

Rasmussen, S. A., Meier, S., Gedsted Andersen, N., Blossom, H., Duus, J. Ø., Nielsen, K. F. & Larsen, T. O., 2016, In : Planta Medica. 81, S 01, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Co-evolution of secondary metabolite gene clusters and their host

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Rasmussen, J. L. N., Theobald, S., Larsen, T. O., Mortensen, U. H. & Andersen, M. R., 2016. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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116 Downloads (Pure)

Comparative genomics of four Aspergillus species with focus on identification of specific secondary metabolite gene clusters

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Rasmussen, J. L. N., Theobald, S., Grigoriev, I., Baker, S. E., Larsen, T. O. & Andersen, M. R., 2016, Book of abstracts from the 13th European Conference on Fungal Genetics. p. 418-418 1 p. CS5T31

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

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152 Downloads (Pure)

Extrolites of Aspergillus fumigatus and Other Pathogenic Species in Aspergillus Section Fumigati

Frisvad, J. C. & Larsen, T. O., 2016, In : Frontiers in Microbiology. 6, 14 p., 1485.

Research output: Contribution to journalJournal articleResearchpeer-review

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How Aspergilli rearrange secondary metabolic gene clusters to generate new compounds

Theobald, S., Vesth, T. C., Rasmussen, J. L. N., Frisvad, J. C., Nielsen, K. F., Larsen, T. O., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2016, Book of abstracts from the 13th European Conference on Fungal Genetics. p. 405-4005 1 p. CS5T18

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

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104 Downloads (Pure)

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

Nielsen, M. L., Petersen, T. I., Petersen, L. M., Mortensen, U. H., Andersen, M. R., Hoof, J. B. & Larsen, T. O., 2016, In : P L o S One. 11, 8, 18 p., e0161199.

Research output: Contribution to journalJournal articleResearchpeer-review

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357 Downloads (Pure)