Research Output per year
Research Output per year
Professor
Søltofts Plads, 224, 210
2800 Kgs. Lyngby
Denmark
Research output per year
The research focuses on host-microbiota interactions in life-style mediated diseases, with particular focus on allergy, asthma, inflammatory bowel diseases, obesity-related disorders and functional somatic disorders. In this regard, we have specific interest in early-in-life programming of immune function towards later disease trajectories, in mechanisms controlling immune regulation at barrier sites such as the gut and lungs, and in the gut-brain axis. We continuously expand and use high-throughput single-cell technologies, high sensitivity antibody-based assays and proteomics to define functional immune cell subsets, signaling molecules and biomarkers in tissues, mucosal secretions and blood from clinical studies in children and adults, and in experimental model systems. We examine host factors of importance for host-microbe interactions by use of co-culture models of microbes with primary epithelial and immune cells and develop bioinformatics-based tools to decipher the type of microbial immunoregulatory metabolites and compounds in human metagenomic samples from the intestine and airway compartments. The work is centered on systems wide analysis, and the group has made recent major achievements regarding microbiome-immune interactions in relation to programming of different asthma disease endotypes during childhood.
Research keywords: Diet, gut and lung microbiomes (abundance and function), sequencing of Ig-coated bacteria to identify disease-driving microbes, profiling of immune cell heterogeneity and functionality in tissues, inflammatory responses, immune regulation (in vivo and experimental systems), early life programming and lifestyle-associated diseases.
PhD in Immunology
Award Date: 30 Sep 2005
MSc chemical engineering/biotechnology
Award Date: 6 Jul 1998
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
01/12/2020 → 30/11/2023
Project: PhD
Dehli, R. I., Brix, S., Hansen, P. R. & Nielsen, C. H.
01/09/2020 → 31/08/2023
Project: PhD
Jin, X., Brix, S., Workman, C. & Fang, X.
01/12/2019 → 30/11/2022
Project: PhD
Rønne, M. E., Svensson, B., Brix, S. & auf dem Keller, U.
01/09/2019 → 31/08/2022
Project: PhD
Merklinger, L., Morth, J. P., Brix, S. & auf dem Keller, U.
01/01/2019 → 31/12/2021
Project: PhD
Susanne Brix (Member)
Activity: Membership › Membership of commitees, commissions, boards, councils, associations, organisations, or similar
Susanne Brix Pedersen (Participant)
Activity: Membership › Membership of commitees, commissions, boards, councils, associations, organisations, or similar
Susanne Brix Pedersen (Visiting researcher)
Activity: Visiting an external institution › Visiting another research institution
Susanne Brix Pedersen (Participant)
Activity: Membership › Membership of commitees, commissions, boards, councils, associations, organisations, or similar
Susanne Brix Pedersen (Participant)
Activity: Membership › Membership in review committee
23/06/2016
1 Media contribution
Press/Media: Press / Media
22/06/2016
1 Media contribution
Press/Media: Press / Media
13/11/2015
1 Media contribution
Press/Media: Press / Media
12/11/2015
1 Media contribution
Press/Media: Press / Media