Sunil Kumar Saini

2024

Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines

Kovalchik, K. A., Hamelin, D. J., Kubiniok, P., Bourdin, B., Mostefai, F., Poujol, R., Paré, B., Simpson, S. M., Sidney, J., Bonneil, É., Courcelles, M., Saini, S. K., Shahbazy, M., Kapoor, S., Rajesh, V., Weitzen, M., Grenier, J. C., Gharsallaoui, B., Maréchal, L. & Wu, Z. & 9 others, Savoie, C., Sette, A., Thibault, P., Sirois, I., Smith, M. A., Decaluwe, H., Hussin, J. G., Lavallée-Adam, M. & Caron, E., 2024, In: Nature Communications. 15, 1, 22 p., 10316.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

13 Downloads (Pure)

2023

Additive effects of booster mRNA vaccination and SARSCoV-2 Omicron infection on T cell immunity across immunocompromised states

Müller, T. R., Sekine, T., Trubach, D., Niessl, J., Chen, P., Bergman, P., Blennow, O., Hansson, L., Mielke, S., Nowak, P., Vesterbacka, J., Akber, M., Olofsson, A., Hernandez, S. P. A., Gao, Y., Cai, C., Söderdahl, G., Smith, C. I. E., Österborg, A. & Loré, K. & 7 others, Chen, M. S., Ljungman, P., Ljunggren, H. G., Karlsson, A. C., Saini, S. K., Aleman, S. & Buggert, M., 2023, In: Science Translational Medicine. 15, 704, 15 p., eadg9452.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

Herpesvirus immunology in solid organ transplant recipients – liver transplant study (HISTORY): a retrospective and prospective observational cohort study

Suarez-Zdunek, M. A., Saini, S. K., Pedersen, C. R., Hamm, S. R., Hald, A., Rasmussen, A., Hillingsø, J. G., Hadrup, S. R. & Nielsen, S. D., 2023, In: BMC Infectious Diseases. 23, 1, 214.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

46 Downloads (Pure)

Herpes Virus Infections in Kidney Transplant Patients (HINT) – a prospective observational cohort study

Hamm, S. R., Saini, S. K., Hald, A., Vaaben, A. V., Pedersen, N. W., Suarez-Zdunek, M. A., Harboe, Z. B., Bruunsgaard, H., Johansen, I. S., Larsen, C. S., Bistrup, C., Birn, H., Sørensen, S. S., Hadrup, S. R. & Nielsen, S. D., 2023, In: BMC Infectious Diseases. 23, 1, 7 p., 687.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

55 Downloads (Pure)

Three doses of BNT162b2 COVID-19 mRNA vaccine establish long-lasting CD8⁺ T cell immunity in CLL and MDS patients

Hernandez, S. P. A., Hersby, D. S., Munk, K. K., Tamhane, T., Trubach, D., Tagliamonte, M., Buonaguro, L., Gang, A. O., Hadrup, S. R. & Saini, S. K., 2023, In: Frontiers in Immunology. 13, 13 p., 1035344.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

60 Downloads (Pure)

2022

Safety, Outcomes, and T-Cell Characteristics in Patients with Relapsed or Refractory MDS or CMML Treated with Atezolizumab in Combination with Guadecitabine

O'Connell, C. L., Baer, M. R., Duerskov, A., Saini, S. K., Duong, V. H., Kropf, P., Hansen, J. W., Tsao-Wei, D., Jang, H. S., Emadi, A., Holmberg-Thyden, S., Cowland, J., Brinker, B. T., Horwood, K., Burgos, R., Hostetter, G., Youngblood, B. A., Hadrup, S. R., Issa, J. P. & Jones, P. & 3 others, Baylin, S. B., Siddiqi, I. & Grønbaek, K., 2022, In: Clinical Cancer Research. 28, 24, p. 5306-5316

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

8 Downloads (Pure)

2021

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

Litchfield, K., Reading, J. L., Puttick, C., Thakkar, K., Abbosh, C., Bentham, R., Watkins, T. B. K., Rosenthal, R., Biswas, D., Rowan, A., Lim, E., Al Bakir, M., Turati, V., Guerra-Assunção, J. A., Conde, L., Furness, A. J. S., Saini, S. K., Hadrup, S. R., Herrero, J. & Lee, S. H. & 8 others, Van Loo, P., Enver, T., Larkin, J., Hellmann, M. D., Turajlic, S., Quezada, S. A., McGranahan, N. & Swanton, C., 2021, In: Cell. 184, 3, p. 596-614

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

389 Downloads (Pure)

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8⁺ T cell activation in COVID-19 patients

Saini, S. K., Hersby, D. S., Tamhane, T., Povlsen, H. R., Amaya Hernandez, S. P., Nielsen, M., Gang, A. O. & Hadrup, S. R., 2021, In: Science immunology. 6, 58, 22 p., eabf7550.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

147 Downloads (Pure)

2020

Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Saini, S. K., Ørskov, A. D., Bjerregaard, A. M., Unnikrishnan, A., Holmberg-Thydén, S., Borch, A., Jensen, K. V., Anande, G., Bentzen, A. K., Marquard, A. M., Tamhane, T., Treppendahl, M. B., Gang, A. O., Dufva, I. H., Szallasi, Z., Ternette, N., Pedersen, A. G., Eklund, A. C., Pimanda, J. & Grønbæk, K. & 1 others, Hadrup, S. R., 2020, In: Nature Communications. 11, 1, 14 p., 5660.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

201 Downloads (Pure)

The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ghorani, E., Reading, J. L., Henry, J. Y., de Massy, M. R., Rosenthal, R., Turati, V., Joshi, K., Furness, A. J. S., Aissa, A. B., Saini, S. K., Ramskov, S., Georgiou, A., Sunderland, M. W., Wong, Y. N. S., De Mucha, M. V., Day, W., Galvez-Cancino, F., Becker, P. D., Uddin, I. & Ismail, M. & 30 others, Ronel, T., Woolston, A., Jamal-Hanjani, M., Veeriah, S., Birkbak, N. J., Wilson, G. A., Litchfield, K., Conde, L., Guerra-Assunção, J. A., Blighe, K., Biswas, D., Salgado, R., Lund, T., Al Bakir, M., Moore, D. A., Hiley, C. T., Loi, S., Sun, Y., Yuan, Y., AbdulJabbar, K., Turajilic, S., Herrero, J., Enver, T., Hadrup, S. R., Hackshaw, A., Peggs, K. S., McGranahan, N., Chain, B., Swanton, C. & Quezada, S. A., 2020, In: Nature Cancer. 1, 5, p. 546-561

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

301 Downloads (Pure)

2019

Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells

Saini, S. K., Tamhane, T., Anjanappa, R., Saikia, A., Ramskov, S., Donia, M., Svane, I. M., Jakobsen, S. N., Garcia-Alai, M., Zacharias, M., Meijers, R., Springer, S. & Hadrup, S. R., 2019, In: Science immunology. 4, 37, 13 p., eaau9039.

Research output: Contribution to journal › Journal article › Research › peer-review

2018

Human endogenous retroviruses and their implication for immunotherapeutics of cancer

Attermann, A. S., Bjerregaard, A., Saini, S. K., Grønbæk, K. & Hadrup, S. R., 2018, In: Annals of Oncology. 29, 11, p. 2183–2191

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

407 Downloads (Pure)

2017

Novel tools to assist neoepitope targeting in personalized cancer immunotherapy

Saini, S. K., Rekers, N. & Hadrup, S. R., 2017, In: Annals of Oncology. 28, suppl_12, p. 3-10

Research output: Contribution to journal › Journal article › Research › peer-review

2016

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

McGranahan, N., Furness, A. J. S., Rosenthal, R., Andersen, S. R., Lyngaa, R. B., Saini, S. K., Jamal-Hanjani, M., Wilson, G. A., Birkbak, N. J., Hiley, C. T., Watkins, T. B. K., Shafi, S., Murugaesu, N., Mitter, R., Akarca, A. U., Linares, J., Marafioti, T., Henry, J. Y., Van Allen, E. M. & Miao, D. & 16 others, Schilling, B., Schadendorf, D., Garraway, L. A., Makarov, V., Rizvi, N. A., Snyder, A., Hellmann, M. D., Merghoub, T., Wolchok, J. D., Shukla, S. A., Wu, C. J., Peggs, K. S., Chan, T. A., Hadrup, S. R., Quezada, S. A. & Swanton, C., 2016, In: Science. 351, 6280, p. 1463-1469

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

File

658 Downloads (Pure)

Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes

Bentzen, A. K., Marquard, A. M., Lyngaa, R. B., Saini, S. K., Andersen, S. R., Donia, M., Such, L., Furness, A. J. S., McGranahan, N., Rosenthal, R., Straten, P. T., Szallasi, Z. I., Svane, I. M., Swanton, C., Quezada, S. A., Jakobsen, S. N., Eklund, A. C. & Hadrup, S. R., 2016, In: Nature Biotechnology. 34, 10, p. 1037-1045

Research output: Contribution to journal › Journal article › Research › peer-review

Sunil Kumar Saini

Research output

Search results