Sofie Christiansen

2024

Effects of ethanol or ethylene glycol exposure on PPARγ and aromatase expression in adipose tissue

Ardenkjær-Skinnerup, J., Saar, D., Christiansen, S., Svingen, T., Hadrup, N., Brown, K. A., Emanuelli, B., Kragelund, B. B., Ravn-Haren, G. & Vogel, U., 2024, In: Biochemistry and Biophysics Reports. 38, 9 p., 101742.

Research output: Contribution to journal › Journal article › Research › peer-review

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Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project

Svingen, T., Andersson, A. M., Angelova, J., Axelstad, M., Bakker, J., Baumann, L., Beronius, A., Bouftas, N., Chalmel, F., Christiansen, S., Cornil, C., Damdimopoulou, P., Deepika, D., Dollé, M. E. T., Draskau, M. K., Fischer, M. B., Hagen, C. P., Hessel, E., Holmer, M. L. & Hughes, S. & 20 others, Jensen, G., Johansson, H. K. L., Juul, A., Kumar, V., Kumar, S., Lardenois, A., Main, K. M., Mazaud-Guittot, S., Moe, S. J., Mola, G., Parent, A. S., Pineda, R., Rolland, A., Rosenmai, A. K., Song, Y., Suglia, A., Tena-Sempere, M., Wehrli, L., Zilliacus, J. & van Duursen, M., 2024, In: Open Research Europe. 4, 13 p., 68.

Research output: Contribution to journal › Letter › peer-review

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Revealing hidden challenges: an in-depth evaluation of Anogenital Distance (AGD) and Areola/Nipple Retention (NR) assessments in EOGRT Studies, with implications for regulatory toxicology

Axelstad, M., Hass, U., Bichlmaier, I., Simanainen, U., Beausoleil, C., Deweirdt, J., Bergkvist, C. & Christiansen, S., 2024, In: Toxicology Letters. 399, Supplement 2, p. S374 1 p., LP-26.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Risk assessment of Endocrine-Disrupting chemicals: threshold or not and what about mixtures?

Nielsen, B. S., Larsen, P. B., Højriis, S., Christiansen, S., Boberg, J. & Poulsen, P. B., 2024, In: Toxicology Letters. 399, Supplement 2, p. S299 1 p., P20-15.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

2023

Adverse outcome pathway network for endocrine disruption targeting estrogen, androgen and steroidogensis modalities – aspects for methodology development

Zilliacus, J., Draskau, M. K., Johansson, H. K., Rosenmai, A. K., Christiansen, S., Elmelund, E., Holmer, M. L., Damdimopoulou, P., Panagiotou, E. M., van Duursen, M., Bouftas, N., Svingen, T. & Beronius, A., 2023, In: Toxicology Letters. 384, Supplement 1, p. S79-S80 P01-10.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Comparing sensitivity of pubertal and adult 28-day exposure scenarios in female rat toxicity studies using diethylstilbestrol or ketoconazole

Johansson, H. K., Boberg, J., Li, T., Christiansen, S., Draskau, M. K., Damdimopoulou, P. & Svingen, T., 2023. 1 p.

Research output: Contribution to conference › Conference abstract for conference › Research

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Comparison of female rat reproductive effects of pubertal versus adult exposure to known endocrine disruptors

Boberg, J., Li, T., Christiansen, S., Draskau, M. K., Damdimopoulou, P., Svingen, T. & Johansson, H. K. L., 2023, In: Frontiers in Endocrinology. 14, 12 p., 1126485.

Research output: Contribution to journal › Journal article › Research › peer-review

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Exposure to the pesticides linuron, dimethomorph and imazalil alters steroid hormone profiles and gene expression in developing rat ovaries

Boberg, J., Johansson, H. K. L., Franssen, D., Draskau, M. K., Christiansen, S., Cramer, J., Pedersen, M., Parent, A.-S. & Svingen, T., 2023, In: Toxicology Letters. 373, p. 114-122 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

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Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats

Franssen, D., Johansson, H. K. L., Lopez-Rodriguez, D., Lavergne, A., Terwagne, Q., Boberg, J., Christiansen, S., Svingen, T. & Parent, A. S., 2023, In: Frontiers in Endocrinology. 14, 18 p., 1140886.

Research output: Contribution to journal › Journal article › Research › peer-review

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Quantitative analysis of ovarian surface photographs as a tool for assessment of chemical effects on folliculogenesis and ovulation in rats

Li, T., Boberg, J., Johansson, H. K. L., Di Nisio, V., Christiansen, S., Svingen, T. & Damdimopoulou, P., 2023, In: Reproductive Toxicology. 119, 7 p., 108416.

Research output: Contribution to journal › Journal article › Research › peer-review

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2022

AOP key event relationship report: Linking androgen receptor antagonism with nipple retention

Pedersen, E. B., Christiansen, S. & Svingen, T., 2022, In: Current Research in Toxicology. 3, 9 p., 100085.

Research output: Contribution to journal › Journal article › Research › peer-review

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Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland

Matouskova, K., Szabo, G. K., Daum, J., Fenton, S. E., Christiansen, S., Soto, A. M., Kay, J. E., Cardona, B. & Vandenberg, L. N., 2022, In: Reproductive Toxicology. 112, p. 51-67 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities

Kay, J. E., Cardona, B., Rudel, R. A., Vandenberg, L. N., Soto, A. M., Christiansen, S., Birnbaum, L. S. & Fenton, S. E., 2022, In: Current Environmental Health Reports. 9, p. 535-562 28 p.

Research output: Contribution to journal › Journal article › Research › peer-review

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Dansk sammendrag af rapport om ”Forbedret kemikaliesikkerhed for hormonforstyrrende stoffer, alene og i cocktails” – ”FEMINIX”

Svingen, T., Christiansen, S., Davidsen, N., Axelstad, M., Ramhøj, L., Boberg, J., Taxvig, C., Ballegaard, A.-S. R. & Rosenmai, A. K., 2022, 4 p.. No. 21/1039385, Jul 01, 2022.

Research output: Memorandum/exposition › Memorandum

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Editorial: Women in developmental and reproductive toxicology: 2021

Adibi, J. J., Christiansen, S., Fenton, S. E., Holloway, A. & Patisaul, H. B., 2022, In: Frontiers in Toxicology. 4, 2 p., 1026314.

Research output: Contribution to journal › Editorial › peer-review

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Using alternative test methods to predict endocrine disruption and reproductive adverse outcomes: do we have enough knowledge?

Svingen, T., Schwartz, C. L., Rosenmai, A. K., Ramhøj, L., Johansson, H. K. L., Hass, U., Draskau, M. K., Davidsen, N., Christiansen, S., Ballegaard, A.-S. R. & Axelstad, M., 2022, In: Environmental Pollution. 304, 8 p., 119242.

Research output: Contribution to journal › Review › peer-review

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2021

Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole

Johansson, H. K. L., Christiansen, S., Draskau, M. K., Svingen, T. & Boberg, J., 2021, In: Reproductive Toxicology. 101, p. 9-17

Research output: Contribution to journal › Journal article › Research › peer-review

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Human-relevant concentrations of the antifungal drug clotrimazole disrupts maternal and fetal steroid hormone profiles in rats

Draskau, M. K., Rosenmai, A. K., Scholze, M., Pedersen, M., Boberg, J., Christiansen, S. & Svingen, T., 2021, In: Toxicology and Applied Pharmacology. 422, 10 p., 115554.

Research output: Contribution to journal › Journal article › Research › peer-review

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On the Use and Interpretation of Areola/Nipple Retention as a Biomarker for Anti-androgenic Effects in Rat Toxicity Studies

Lindgren Schwartz, C., Christiansen, S., Hass, U., Ramhøj, L., Axelstad, M., Michelle Löbl, N. & Svingen, T., 2021, In: Frontiers in Toxicology. 3, 22 p., 730752.

Research output: Contribution to journal › Journal article › Research › peer-review

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101 Downloads (Pure)

2020

Faglig vurdering af foreløbig SCCS vurdering for Homosalat

Christiansen, S., Axelstad Petersen, M. & Boberg, J., 2020, 9 p.. No. 21/1030799, Dec 18, 2020.

Research output: Memorandum/exposition › Memorandum

Open Access

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249 Downloads (Pure)

Faglig vurdering af foreløbig SCCS vurdering for Propylparaben

Boberg, J., Christiansen, S. & Axelstad Petersen, M., 2020, 6 p.. No. 21/1030799, Dec 18, 2020.

Research output: Memorandum/exposition › Memorandum

Open Access

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Faglig vurdering af foreløbig SCCS vurdering for resorcinol

Axelstad Petersen, M., Christiansen, S. & Boberg, J., 2020, 7 p.. No. 21/1030799, Dec 18, 2020.

Research output: Memorandum/exposition › Memorandum

Open Access

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27 Downloads (Pure)

Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study

Christiansen, S., Axelstad, M. A., Scholze, M., Johansson, H. K. L., Hass, U., Mandrup, K. M., Frandsen, H. L., Frederiksen, H., Isling, L. K. & Boberg, J., 2020, In: Environment International. 142, 105870.

Research output: Contribution to journal › Journal article › Research › peer-review

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MIraculiX - Strengthened risk assessment of chemicals

Vinggaard, A. M., Svingen, T., Boberg, J., Taxvig, C., Christiansen, S., Frandsen, H. L., Pedersen, M., Petersen, A., Bredsdorff, L., Nielsen, E. E., Jensen, B. H., Dybdahl, M., Christensen, T., Fagt, S., Plesning, B. M., Letting, H. B., Sztuk, L., El-Baroudy, U., Jørgensen, V. & Lykkegaard Korsbech, D. & 12 others, Jessen, M. V., Ørngreen, A.-M., Johansson, H. K. L., Schwartz, C. V. L., Löbl, N. M., Silva Melo, D., Kortenkamp, A., Scholze, M., Ermler, S., Chalmel, F., Fowler, P. & Nørby, E., 2020, Kgs. Lyngby: Technical University of Denmark. 42 p.

Research output: Book/Report › Report › Commissioned

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Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

Johansson, H. K. L., Damdimopoulou, P., van Duursen, M. B. M., Boberg, J., Franssen, D., de Cock, M., Jääger, K., Wagner, M., Velthut-Meikas, A., Xie, Y., Connolly, L., Lelandais, P., Mazaud-Guittot, S., Salumets, A., Draskau, M. K., Filis, P., Fowler, P. A., Christiansen, S., Parent, A. S. & Svingen, T., 2020, In: Archives of Toxicology. 94, p. 3359–3379

Research output: Contribution to journal › Review › peer-review

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Quantitative in Vitro to in Vivo Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders

Scholze, M., Taxvig, C., Kortenkamp, A., Boberg, J., Christiansen, S., Svingen, T., Lauschke, K., Frandsen, H. L., Ermler, S., Hermann, S. S., Pedersen, M., Lykkeberg, A. K., Axelstad Petersen, M. Z. & Vinggaard, A. M., 2020, In: Environmental Health Perspectives. 128, 11, 17 p., 117005.

Research output: Contribution to journal › Journal article › Research › peer-review

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Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project

Kortenkamp, A., Axelstad Petersen, M., Baig, A. H., Bergman, Å., Bornehag, C.-G., Cenijn, P., Christiansen, S., Demeneix, B., Derakhshan, A., Fini, J.-B., Frädrich, C., Hamers, T., Hellwig, L., Köhrle, J., Korevaar, T. I. M., Lindberg, J., Martin, O., Meima, M. E., Mergenthaler, P. & Georgiev Nikolov, N. & 12 others, Du Pasquier, D., Peeters, R. P., Platzack, B., Ramhøj, L., Remaud, S., Renko, K., Scholze, M., Stachelscheid, H., Svingen, T., Wagenaars, F., Wedebye, E. B. & Zoeller, R. T., 2020, In: International Journal of Molecular Sciences . 21, 9, 13 p., 3123.

Research output: Contribution to journal › Journal article › Research › peer-review

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Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project

Duursen, M. B. M. V., Boberg, J., Christiansen, S., Connolly, L., Damdimopoulou, P., Filis, P., Fowler, P. A., Gadella, B. M., Holte, J., Jääger, K., Johansson, H. K. L., Li, T., Mazaud-Guittot, S., Parent, A.-S., Salumets, A., Soto, A. M., Svingen, T., Velthut-Meikas, A., Wedebye, E. B. & Xie, Y. & 1 others, Berg, M. V. D., 2020, In: International Journal of Molecular Sciences . 21, 9, 13 p., 3215.

Research output: Contribution to journal › Journal article › Research › peer-review

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2019

Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders

Lindgren Schwartz, C. V., Christiansen, S., Vinggaard, A. M., Axelstad Petersen, M., Hass, U. & Svingen, T., 2019, In: Archives of Toxicology. 93, 2, p. 253-272

Research output: Contribution to journal › Review › peer-review

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Distinct transcriptional profiles of the female, male and finasteride-induced feminized male anogenital region in rat fetuses

Lindgren Schwartz, C. V., Vinggaard, A. M., Christiansen, S., Darde, T. A., Chalmel, F. & Svingen, T., 2019, In: Toxicological Sciences. 169, 1, p. 303-311

Research output: Contribution to journal › Journal article › Research › peer-review

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In Utero Exposure to the Azole Fungicide Triticonazole Disrupts Reproductive Development in Rats

Draskau, M. K., Boberg, J., Taxvig, C., Pedersen , M., Frandsen, H. L., Christiansen, S. & Svingen, T., 2019. 1 p.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

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In vitro and in vivo endocrine disrupting effects of the azole fungicides triticonazole and flusilazole

Draskau, M. K., Boberg, J., Taxvig, C., Pedersen, M., Frandsen, H. L., Christiansen, S. & Svingen, T., 2019, In: Environmental Pollution. 255, Part 2, 11 p., 113309.

Research output: Contribution to journal › Journal article › Research › peer-review

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Quantitative in vitro to in vivo extrapolation (IVIVE) predict adverse male reproductive health disorders caused by pesticides

Taxvig, C., Scholze, M., Kortenkamp, A., Boberg, J., Svingen, T., Lauschke, K., Christiansen, S., Ermler, S., Hermann, S. S., Pedersen, M., Frandsen, H., Kruse Lykkeberg, A. & Vinggard, A. M., 2019, In: Toxicology Letters. 314, SI, p. S38-S38 #1005.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Open Access

2018

A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making

Ågerstrand, M., Christiansen, S., Hanberg, A., Rudén, C., Andersson, L., Andersen, S., Appelgren, H., Bjørge, C., Clausen, I. H., Eide, D. M., Hartmann, N. B., Husøy, T., Halldórsson, H. P., van der Hagen, M., Ingre-Khans, E., Lillicrap, A. D., Beltoft, V. M., Mörk, A.-K., Murtomaa-Hautala, M. & Nielsen, E. E. & 8 others, Ólafsdóttir, K., Palomäki, J., Papponen, H., Reiler, E. M., Stockmann-Juvala, H., Suutari, T., Tyle, H. & Beronius, A., 2018, In: Journal of Applied Toxicology. 38, 5, p. 783-785

Research output: Contribution to journal › Journal article › Research › peer-review

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Characterizing novel molecular mechanisms for short AGD – a biomarker of fetal testicular dysfunction

Schwartz, C. V. L., Vinggaard, A. M., Christiansen, S., Chalmel, F. & Svingen, T., 2018. 1 p.

Research output: Contribution to conference › Poster › Research › peer-review

Combination effects of pesticides on birth weight and metabolic programming in rat offspring

Hass, U., Christiansen, S., Boberg, J., Petersen, M. A., Egebjerg, K. M., Vinggaard, A. M., Taxvig, C., Svingen, T., Ramhøj, L. & Scholze, M., 2018, København Ø: Environmental Protection Agency. 78 p.

Research output: Book/Report › Report › Commissioned

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EDC IMPACT: Reduced sperm counts in rats exposed to human relevant mixtures of endocrine disrupters

Axelstad Petersen, M., Hass, U., Scholze, M., Christiansen, S., Kortenkamp, A. & Boberg, J., 2018, In: Endocrine Connections. 7, 1, p. 139-148 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

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Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides

Svingen, T., Ramhøj, L., Egebjerg, K. M., Christiansen, S., Petersen, M. A., Vinggaard, A. M. & Hass, U., 2018, In: Scientific Reports. 8, 10 p., 305.

Research output: Contribution to journal › Journal article › Research › peer-review

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Environmental toxicology: Pesticides

Svingen, T., Christiansen, S., Taxvig, C. & Vinggaard, A. M., 2018, Encyclopedia of Reproduction. Skinner, M. (ed.). 2 ed. Academic Press, Vol. 1. p. 624-628 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research › peer-review

Feasibility study for minor enhancements of tg 414 (prenatal developmental toxicity study) with endocrine disrupter-relevant endpoints series on testing and assesment number 285

Christiansen, S. & Hass, U., 2018, Paris, France: Organisation for Economic Co-operation and Development. 30 p.

Research output: Book/Report › Report › Commissioned

Open Access

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Input til høringssvar vedrørende ny opinion for salicylsyre

Hass, U., Petersen, M. A. & Christiansen, S., 2018, 3 p.. No. 18/15413, Nov 08, 2018.

Research output: Memorandum/exposition › Memorandum

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Perfluorohexane Sulfonate (PFHxS) and a Mixture of Endocrine Disrupters Reduce Thyroxine Levels and Cause Anti-Androgenic Effects in Rats

Ramhøj, L., Hass, U., Boberg, J., Scholze, M., Christiansen, S., Nielsen, F. & Axelstad Petersen, M., 2018, In: Toxicological Sciences. 163, 2, p. 579-591

Research output: Contribution to journal › Journal article › Research › peer-review

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2017

3R activities in the research group for molecular and reproductive toxicology at the National Food Institute

Wedebye, E. B., Dybdahl, M., Christiansen, S. & Svingen, T., 2017, 2017 Annual Report: The Danish 3R-Center . Glostrup: Danmarks 3R-Center, p. 59-63

Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research › peer-review

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Sofie Christiansen

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