Personal profile
Profile
The major research interest of the past 10 years has been microbial biofilms in relation to cell-cell interactions and developmental processes. The knowledge obtained in the course of this work is now being further developed in connection with detailed studies of microbial adaptation and evolution in cases of chronic infections. These current research activities are based on the assumption that fundamental studies of bacteria physiology and ecology are essential if we wish to understand and eventually interfere with such microbial infections. The investigations employ several methods providing global information about the cells’ genomes and functional genomics. In particular, specific clones of bacteria infecting airways of cystic fibrosis patients are studied. In connection with these studies evolution of antibiotic resistance is an important topic where the current focus point is resistance mechanisms involved in tolerance to anti-microbial peptides. Development of various types of laboratory model systems for simulation of human infections in vitro has been added to the research program.
Keywords
- User defined:
- Biofilms, chronic infections, functional genomics, evolution, antibiotic resistance, bacterial physiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 6 Clean Water and Sanitation -
SDG 12 Responsible Consumption and Production -
SDG 13 Climate Action -
SDG 14 Life Below Water
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Collaborations and top research areas from the last five years
Publications
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Cell-type-independent infection dynamics of clinical Pseudomonas aeruginosa isolates in human airway epithelial models
Colque, C. A., Lolle, S., La Rosa, R., Bendixen, M. P., Rudjord-Levann, A. M., Simões, F. B., Aanæs, K., Molin, S. & Johansen, H. K., 2026, In: Cell Reports. 45, 2, 116951.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Downloads (Orbit) -
The Pseudomonas aeruginosa sirB2 gene is a fitness determinant of anaerobic growth and its inactivation affects virulence and rugose small colony variants emergence
Baldelli, V., Carrasco Aliaga, S. J., Colque, C. A., Mazzola, F., Ravishankar, S., Johansen, H. K., Molin, S., Raffaelli, N., Paroni, M., Landini, P. & Rossi, E., 2026, In: Virulence. 17, 1, 2605800.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Downloads (Orbit) -
Ciprofloxacin resistance rapidly declines in nfxB defective clinical strains of Pseudomonas aeruginosa
Hernando-Amado, S., Laborda, P., La Rosa, R., Molin, S., Johansen, H. K. & Martínez, J. L., 2025, In: Nature Communications. 16, 1, 12 p., 4992.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile14 Downloads (Orbit) -
Establishment of a 3D-Printed Tissue-on-a-Chip Model for Live Imaging of Bacterial Infections
Fuglsang-Madsen, A., Haagensen, J. A. J., De Rudder, C., Simões, F. B., Molin, S. & Johansen, H. K., 2025, Advances in Experimental Medicine and Biology. 17 p. (Advances in Experimental Medicine and Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Open AccessFile49 Downloads (Orbit) -
Occurrence of type VI secretion system effector genes in longitudinal isolates of P. aeruginosa from people with cystic fibrosis
Habich, A., Liu, Y., Ghoul, M., Andersen, S. B., Johansen, H. K., Molin, S., Griffin, A. S. & Unterweger, D., 2025, In: Microbial Genomics. 11, 11, 001555.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Downloads (Orbit)
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Involvement of cell-cell communication systems in co-ordinated behavior of bacteria.
Givskov, M. C. (Project Manager), Molin, S. (Project Participant), Kjelleberg, S. (Project Participant), Christophersen, C. (Project Participant), Anthoni, U. (Project Participant) & Eberl, L. (Project Participant)
01/01/1996 → 01/01/9999
Project: Research
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Characterization of microbiomesin infected human lungs
Madsen, K. (PhD Student), Molin, S. (Main Supervisor), Johansen, H. K. (Supervisor), Jelsbak, L. (Examiner) & Unterweger, D. (Examiner)
01/02/2022 → 05/11/2025
Project: PhD
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Development of biotechnological tools for modulating the microbiome of industrial sugarcane ethanol fermentations
Senne de Oliveira Lino, F. (PhD Student), Sommer, M. O. A. (Main Supervisor), Molin, S. (Supervisor), Jensen, M. K. (Examiner), Guadelupe Medina, V. G. (Examiner) & van Maris, A. (Examiner)
01/09/2016 → 17/08/2020
Project: PhD
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Profiling evolutionary Landscapes underlying drug resistance
Hickman, R. A. (PhD Student), Sommer, M. O. A. (Main Supervisor), Molin, S. (Supervisor), Weber, T. (Examiner), Andersson, D. I. (Examiner) & Ingmer, H. (Examiner)
Technical University of Denmark
15/12/2013 → 25/08/2017
Project: PhD
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Population dynamics in microbial cell factories
Christensen, A.-M. J. (PhD Student), Sternberg, C. (Main Supervisor), Molin, S. (Supervisor), Jelsbak, L. (Examiner), Bühler, K. (Examiner) & Tolker-Nielsen, T. (Examiner)
15/11/2013 → 26/04/2017
Project: PhD
Activities
- 5 Conference presentations
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Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers
Birk, S. E. (Speaker), Serioli Øland, L. (Other), Cavallo, V. (Other), Haagensen, J. A. J. (Other), Molin, S. (Other), Zor, K. (Other), Nielsen, L. H. (Other) & Boisen, A. (Other)
29 Jun 2020 → 2 Jul 2020Activity: Talks and presentations › Conference presentations
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Can Microcontainers be used to Improve Treatment of Biofilms?
Hansen, S. E. (Speaker), Nielsen, L. H. (Other), Haagensen, J. A. J. (Other), Johansen, H. K. (Other), Molin, S. (Other) & Boisen, A. (Other)
21 Jul 2019 → 24 Jul 2019Activity: Talks and presentations › Conference presentations
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Establishing bacterial cell cultures on a centrifugal platform for monitoring of antibiotic resistance and biofilm development
Serioli, L. (Other), Z. Laksafoss, T. (Other), Severini, G. (Other), Adesokan, B. J. (Other), Haagensen, J. A. J. (Other), Sørensen, M. P. (Other), Molin, S. (Other), Johansen, H. K. (Other), Demarchi, D. (Other), Zor, K. (Other) & Boisen, A. (Other)
12 Jun 2018 → 15 Jun 2018Activity: Talks and presentations › Conference presentations
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Centrifugal microfluidic platform for optical monitoring and treatment of biofilms
Serioli, L. (Other), Severini, G. (Other), Z. Laksafoss, T. (Other), Haagensen, J. A. J. (Other), Sørensen, M. P. (Other), Molin, S. (Other), Johansen, H. K. (Other), Zor, K. (Other) & Boisen, A. (Other)
24 Sept 2018 → 27 Sept 2018Activity: Talks and presentations › Conference presentations
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Role of Lipopolysaccharide in colonization of the mouse intestine by Salmonella typhimurium
Molin, S. (Speaker)
1 Jan 1996 → …Activity: Talks and presentations › Conference presentations