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Research Output

2019

Metabolic and regulatory insights from the experimental Horizontal Gene Transfer of the aurofusarin and bikaverin gene clusters to Aspergillus nidulans

de Reus, E., Nielsen, M. R. & Frandsen, R. J. N., 2019, In : Molecular Microbiology. 112, 6, p. 1684-1700 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2018

Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans

Frandsen, R. J. N., Khorsand-Jamal, P., Kongstad, K. T., Nafisi, M., Kannangara, R. M., Stærk, D., Okkels, F. T., Binderup, K., Madsen, B., Møller, B. L., Thrane, U. & Mortensen, U. H., 2018, In : Scientific Reports. 8, 1

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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270 Downloads (Pure)

Identification of the decumbenone biosynthetic gene cluster in Penicilliuum decumbens and the importance for production of calbistrin

Grijseels, S., Pohl, C., Nielsen, J. C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2018, In : Fungal Biology and Biotechnology. 5, 17 p., 18.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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189 Downloads (Pure)

In vivo engineering of polyketide synthases

Olsen, K. J. K., Larsen, T. O. & Frandsen, R. J. N., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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112 Downloads (Pure)

On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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328 Downloads (Pure)
2017

An experimental approach to studying the role of Horizontal Gene Transfer in shaping fungal secondary metabolism

de Reus, P. E., Nielsen, K. F. N. & Frandsen, R. J. N., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, R., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, K. T., Stærk, D., Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, B. L., 2017, In : Nature Communications. 8, 1, 12 p., 1987 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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263 Downloads (Pure)

Elucidating the biosynthetic pathway of the anticancer secondary metabolite calbistrin in Penicillium decumbens

Grijseels, S., Pohl, C., Wasil, Z., Froslev Nielsen, J. C., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2017. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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147 Downloads (Pure)

Gene expression plasticity across hosts of an invasive scale insect species

Christodoulides, N., Van Dam, A., Peterson, D. A., Frandsen, R. J. N., Mortensen, U. H., Petersen, B., Rasmussen, S., Normark, B. B. & Hardy, N. B., 2017, In : P L o S One. 12, 5, 13 p., e0176956.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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247 Downloads (Pure)

Microbial platform for production of aromatic compounds

Skovbjerg, C. A. E., Olsen, K. J. K., Larsen, T. O. & Frandsen, R. J. N., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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187 Downloads (Pure)

Physiological characterization of secondary metabolite producing Penicillium cell factories

Grijseels, S., Nielsen, J., Nielsen, J., Larsen, T. O., Frisvad, J. C., Nielsen, K. F., Frandsen, R. J. N. & Workman, M., 2017, In : Fungal Biology and Biotechnology. 4, 8, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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412 Downloads (Pure)

Synthesis of C-Glucosylated Octaketide Anthraquinones in Nicotiana benthamiana by Using a Multispecies-Based Biosynthetic Pathway

Andersen-Ranberg, J., Kongstad, K. T., Nafisi, M., Stærk, D., Okkels, F. T., Mortensen, U. H., Møller, B. L., Frandsen, R. J. N. & Kannangara, R., 2017, In : Chembiochem. 18, 19, p. 1893-1897

Research output: Contribution to journalJournal articleResearchpeer-review

2016

Adaptation of the pET-Duet expression system to USER-Fusion based cloning – using statin biosynthesis as a case study

Futyma, M. E. & Frandsen, R. J. N., 2016, In : Planta Medica. 82, S 01, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Black perithecial pigmentation in Fusarium species is due to the accumulation of 5-deoxybostrycoidin-based melanin

Frandsen, R. J. N., Rasmussen, S. A., Knudsen, P. B., Uhlig, S., Petersen, D., Lysøe, E., Gotfredsen, C. H., Giese, H. & Larsen, T. O., 2016, In : Scientific Reports. 6, 13 p., 26206.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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319 Downloads (Pure)

Draft genome sequence and chemical profiling of Fusarium langsethiae, an emerging producer of type A trichothecenes

Lysøe, E., Frandsen, R. J. N., Divon, H. H., Terzi, V., Orrù, L., Lamontanara, A., Kolseth, A. K., Nielsen, K. F. & Thrane, U., 2016, In : International Journal of Food Microbiology. 221, p. 29-36 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Glycosyltransferase glycosylating flavokermesic acid and/or kermesic acid

Kannangara, R. M., Bennedsen, M., Madsen, B., Binderup, K., Thrane, U., Frandsen, R. J. N., Mortensen, U. H., Møller, B. L. & Okkels, F. T., 26 Oct 2016, IPC No. C12P 7/ 66 A I, Patent No. EP3083950, 29 Nov 2017, Priority date 18 Dec 2014, Priority No. WO2014EP78540

Research output: Patent

Open Access
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42 Downloads (Pure)

Prediction of secondary metabolite encoding genes based on chemical structure analysis

Petersen, T. I., Nielsen, M. L., Hoeck, C., Frandsen, R. J. N. & Larsen, T. O., 2016, Book of abstracts from the 13th European Conference on Fungal Genetics. p. 458-458 1 p. CS5T73

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
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251 Downloads (Pure)

Prediction of secondary metabolite encoding genes based on chemical structure analysis

Petersen, T. I., Nielsen, M. L., Hoeck, C., Gezgin, Y., Frandsen, R. J. N., Nielsen, K. F. & Larsen, T. O., 2016, In : Planta Medica. 81, S 01, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Secondary Metabolites of Fusarium graminearum: Toxic to microbes and effectors in virulence

Glasenapp, A., Malz, S., Frandsen, R. J. N. & Schäfer, W., 2016, Book of abstracts from the 13th European Conference on Fungal Genetics. p. 528-528 1 p. CS7W1

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
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260 Downloads (Pure)

Use of heterologous expressed polyketide synthase and small molecule foldases to make aromatic and cyclic compounds

Frandsen, R. J. N., Mortensen, U. H., Coumou, H., Kannangara, R., Madsen, L., Nafisi, M., Ranberg, J. A., Kongstad, K. T., T. Okkels, F., Khorsand-Jamal, P. & Stærk, D., 15 Dec 2016, IPC No. C12P 19/ 60 A I, Patent No. WO2016198623, 15 Dec 2016, Priority date 10 Jun 2015, Priority No. EP20150171430

Research output: Patent

Open Access
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134 Downloads (Pure)

Use of octaketide synthases to produce kermesic acid and flavokermesic acid

Møller, B. L., Madsen, B., Stærk, D., Okkels, F. T., Andersen-Ranberg, J., Kongstad, K. T., Binderup, K., Bennedsen, M., Nafisi, M., Khorsand-Jamal, P., Kannangara, R. M., Mortensen, U. H., Thrane, U. & Frandsen, R. J. N., 15 Dec 2016, IPC No. C12P 17/ 06 A I, Patent No. WO2016198564, 15 Dec 2016, Priority date 10 Jun 2015, Priority No. EP20150171375

Research output: Patent

Open Access
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110 Downloads (Pure)
2015

Agrobacterium tumefaciens-Mediated Transformation

Frandsen, R. J. N., 2015, Genetic Transformation Systems in Fungi. van den Berg, M. A. & Maruthachalam, K. (eds.). Springer, Vol. 1. p. 143-162 20 p. (Fungal Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Combining Stable Isotope Labeling and Molecular Networking for Biosynthetic Pathway Characterization

Klitgaard, A., Nielsen, J. B., Frandsen, R. J. N., Andersen, M. R. & Nielsen, K. F., 2015, In : Analytical Chemistry. 87, 13, p. 6520-6526 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Combining UHPLC-High Resolution MS and Feeding of Stable Isotope Labeled Polyketide Intermediates for Linking Precursors to End Products

Klitgaard, A., Frandsen, R. J. N., Holm, D. K., Knudsen, P. B., Frisvad, J. C. & Nielsen, K. F., 2015, In : Journal of Natural Products. 78, 7, p. 1518-1525 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Expression profiling and functional analyses of BghPTR2, a peptide transporter from Blumeria graminis f. sp. hordei

Droce, A., Holm, K. B., Olsson, S., Frandsen, R. J. N., Sondergaard, T. E., Sørensen, J. L. & Giese, H., 2015, In : Fungal Biology. 119, 7, p. 551-559 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Heterologous expression of MlcE in Saccharomyces cerevisiae provides resistance to natural and semi-synthetic statins

Ley, A., Coumou, H. C. & Frandsen, R. J. N., 2015, In : Metabolic Engineering Communications. 2, p. 117-123 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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306 Downloads (Pure)

Statin resistance and export

Frandsen, R. J. N., Ley, A. & Naesby, M., 29 Oct 2015, IPC No. A61K 31/ 20 A N, Patent No. WO2015161856, 29 Oct 2015, Priority date 23 Apr 2014, Priority No. EP20140165696

Research output: Patent

Open Access
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44 Downloads (Pure)

Synthetic Yeast Based Cell Factories for the Production of Plant Natural Colors

Coumou, H., Petersen, P. D., Mortensen, M. M., Frandsen, R. J. N., Thrane, U., T. Okkels, F. & Mortensen, U. H., 2015.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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317 Downloads (Pure)
2014

Fusarium graminearum PKS14 is involved in orsellinic acid and orcinol synthesis

Jørgensen, S. H., Frandsen, R. J. N., Nielsen, K. F., Lysøe, E., Sondergaard, T. E., Wimmer, R., Giese, H. & Sørensen, J. L., 2014, In : Fungal Genetics and Biology. 70, p. 24-31 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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855 Downloads (Pure)

Genetic transformation of Fusarium avenaceum by Agrobacterium tumefaciens mediated transformation and the development of a USER-Brick vector construction system

Sorensen, L. Q., Lysøe, E., Larsen, J. E., Khorsand-Jamal, P., Nielsen, K. F. & Frandsen, R. J. N., 2014, In : B M C Molecular Biology. 15, 1, 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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291 Downloads (Pure)

The efflux pump MlcE from the Penicillium solitum compactin biosynthetic gene cluster increases Saccharomyces cerevisiae resistance to natural statins

Ley, A. & Frandsen, R. J. N., 2014.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

The Genome of the Generalist Plant Pathogen Fusarium avenaceum Is Enriched with Genes Involved in Redox, Signaling and Secondary Metabolism.

Lysøe, E., Harris, L. J., Walkowiak, S., Subramaniam, R., Divon, H. H., Riiser, E. S., Llorens, C., Gabaldón, T., Kistler, H. C., Jonkers, W., Kolseth, A-K., Nielsen, K. F., Thrane, U. & Frandsen, R. J. N., 2014, In : P L o S One. 9, 11, 17 p., e112703.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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223 Downloads (Pure)
2013

Molecular Biological basis for statin resistance in naturally statin-producing organisms

Rems, A. & Frandsen, R. J. N., 2013.

Research output: Contribution to conferencePosterResearchpeer-review

One Fungus, One Name: Defining the Genus Fusarium in a Scientifically Robust Way That Preserves Longstanding Use.

Geiser, D. M., Aoki, T., Bacon, C. W., E. Baker, S., Bhattacharyya, M. K., Brandt, M. E., Brown, D. W., Burgess, L. W., Chulze, S., Coleman, J. J., Correll, J. C., Covert, S. F., Crous, P. W., Cuomo, C. A., Sybren De Hoog, G., Di Pietro, A., Elmer, W. H., Epstein, L., Frandsen, R. J. N., Freeman, S. & 46 others, Gagkaeva, T., Glenn, A. E., Gordon, T. R., Gregory, N. F., Hammond-Kosack, K. E., Hanson, L. E., Jímenez-Gasco, M. D. M., Kang, S., Kistler, H. C., Kuldau, G. A., Leslie, J. F., Logrieco, A., Lu, G., Lysøe, E., Ma, L-J., P. McCormick, S., Migheli, Q., Moretti, A., Munaut, F., O'Donnell, K., Pfenning, L., Ploetz, R. C., Proctor, R. H., Rehner, S. A., Robert, V. A. R. G., Rooney, A. P., Salleh, B. B., Scandiani, M. M., Scauflaire, J., Short, D. P. G., Steenkamp, E., Suga, H., Summerell, B. A., Sutton, D. A., Thrane, U., Trail, F., Diepeningen, A. V., VanEtten, H. D., Viljoen, A., Waalwijk, C., Ward, T. J., Wingfield, M. J., Xu, J-R., Yang, X-B., Yli-Mattila, T. & Zhang, N., 2013, In : Phytopathology. 103, 5, p. 400-408

Research output: Contribution to journalLetterResearchpeer-review

Phylogenetic analyses of RPB1 and RPB2 support a middle Cretaceous origin for a clade comprising all agriculturally and medically important fusaria

O’Donnell, K., Rooney, A. P., Proctor, R. H., Brown, D. W., McCormick, S. P., Ward, T. J., Frandsen, R. J. N., Lysøe, E., Rehner, S. A., Aoki, T., Robert, V. A. R. G., Crous, P. W., Groenewald, J. Z., Kang, S. & Geiser, D. M., 2013, In : Fungal Genetics and Biology. 52, p. 20-31

Research output: Contribution to journalJournal articleResearchpeer-review

Reconstruction of the biosynthetic pathway for the core fungal polyketide scaffold rubrofusarin in Saccharomyces cerevisiae

Rugbjerg, P., Naesby, M., Mortensen, U. H. & Frandsen, R. J. N., 2013, In : Microbial Cell Factories. 12, 1, 9 p., 31.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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203 Downloads (Pure)

The Effect of Nanosilver on Pigments Production by Fusarium culmorum (W. G. Sm.) Sacc.

Kasprowicz, M. J., Gorczyca, A. & Frandsen, R. J. N., 2013, In : Polish Journal of Microbiology. 62, 4, p. 365-372

Research output: Contribution to journalJournal articleResearchpeer-review

2012

Genetics of Polyketide Metabolism in Aspergillus nidulans

Klejnstrup, M. L., Frandsen, R. J. N., Holm, D. K., Nielsen, M. T., Mortensen, U. H., Larsen, T. O. & Nielsen, J. B., 2012, In : Metabolites. 2, 1, p. 100-133

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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442 Downloads (Pure)

Linking of Fusarium graminearum PKS3 to bostrycoidin production

Frandsen, R. J. N., 2012.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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102 Downloads (Pure)

Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum

Sørensen, J. L., Hansen, F. T., Sondergaard, T. E., Staerk, D., Lee, T. V., Wimmer, R., Klitgaard, L. G., Purup, S., Giese, H. & Frandsen, R. J. N., 2012, In : Environmental Microbiology. 14, 5, p. 1159-1170

Research output: Contribution to journalJournal articleResearchpeer-review

Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium

Hansen, J. T., Sørensen, J. L., Giese, H., Sondergaard, T. E. & Frandsen, R. J. N., 2012, In : International Journal of Food Microbiology. 155, 3, p. 128-136

Research output: Contribution to journalJournal articleResearchpeer-review

Targeted Gene Replacement in Fungal Pathogens via Agrobacterium tumefaciens- Mediated Transformation

Frandsen, R. J. N., Frandsen, M. & Giese, N. H., 2012, Plant Fungal Pathogens: Methods and Protocols. Humana Press, Vol. 835. p. 17-45 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Two novel classes of enzymes are required for the biosynthesis of aurofusarin in Fusarium graminearum

Frandsen, R. J. N., Schütt, C., Lund, B. W., Staerk, D., Nielsen, J., Olsson, S. & Giese, H., 2011, In : Journal of Biological Chemistry. 286, 12, p. 10419-10428

Research output: Contribution to journalJournal articleResearchpeer-review

2 Downloads (Pure)
2010

A pre-processing strategy for liquid chromatography time-of-flight mass spectrometry metabolic fingerprinting data

Nielsen, N. J., Tomasi, G., Frandsen, R. J. N., Kristensen, M. B., Nielsen, J., Giese, N. H. & Christensen, J. H., 2010, In : Metabolomics. 6, 3, p. 341-352

Research output: Contribution to journalJournal articleResearchpeer-review

Development of pollution-induced community tolerance is linked to structural and functional resilience of a soil bacterial community following a five-year field exposure to copper

Brandt, K. K., Frandsen, R. J. N., Holm, P. E. & Nybroe, O., 2010, In : Soil Biology & Biochemistry. 42, 5, p. 748-757

Research output: Contribution to journalJournal articleResearchpeer-review

Methylenetetrahydrofolate Reductase Activity Is Involved in the Plasma Membrane Redox System Required for Pigment Biosynthesis in Filamentous Fungi

Frandsen, R. J. N., Albertsen, K. S., Stougaard, P., Sørensen, J. L., Nielsen, K. F., Olsson, S. & Giese, H., 2010, In : Eukaryotic Cell (Online Edition). 9, 8, p. 1225-1235

Research output: Contribution to journalJournal articleResearchpeer-review

2008

Efficient four fragment cloning for the construction of vectors for targeted gene replacement in filamentous fungi

Frandsen, R. J. N., Andersson, J. A., Kristensen, M. B. & Giese, H., 2008, In : BMC Molecular Biology. 9, p. 70

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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226 Downloads (Pure)