19982020
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Research Output 1998 2019

2019
113 Downloads (Pure)

Analysis of dDNP NMR metabolic data from cancer cells

Frahm, A. B., Lundsgaard, E., Matei, A., Jensen, P. R., Karlsson, M., Ardenkjær-Larsen, J. H. & Lerche, M. H., 2019, (Accepted/In press). 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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Combined Rapid Injection NMR and Simulation Approach to Probe Redox-Dependent Pathway Control in Living Cells

Jensen, P. R., Matos, M., Sonnenschein, N. & Meier, S., 2019, In : Analytical Chemistry. 91, 8, p. 5395-5402 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Discovery and Exploration of the Efficient Acyclic Dehydration of Hexoses in DMSO/Water

Taarning, E., Sádaba, I., Jensen, P. R. & Meier, S., 2019, In : ChemSusChem. 12, 23, p. 5086-5091 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Probing the Lewis Acid Catalyzed Acyclic Pathway of Carbohydrate Conversion in Methanol by In Situ NMR

Jensen, P. R., Taarning, E. & Meier, S., 2019, In : ChemCatChem. 11, 20, p. 5077-5084 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Targeted Metabolomics with Quantitative Dissolution Dynamic Nuclear Polarization

Lerche, M. H., Karlsson, M., Ardenkjær-Larsen, J. H. & Jensen, P. R., 2019, NMR-Based Metabolomics. Gowda, G. & Raftery, D. (eds.). Springer, p. 385-393 (Methods in Molecular Biology, Vol. 2037).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

The impact of formate in Shigella flexneri after invading into HeLa cells

Wang, K., Yigit, D., Ardenkjær-Larsen, J. H., Lerche, M. H. & Jensen, P. R., 2019. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Untangling metabolism between infected mammalian host cells and intracellular pathogen

Wang, K., Lerche, M. H., Ardenkjær-Larsen, J. H., Yigit, D. & Jensen, P. R., 2019. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

2018
60 Downloads (Pure)

Analysis of dDNP NMR metabolic data from cancer cells (- poster)

Frahm, A. B., Lundsgaard, E. A., Matei, A., Jensen, P. R., Karlsson, M., Ardenkjær-Larsen, J. H. & Lerche, M. H., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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127 Downloads (Pure)

Kinetic Analysis of Hexose Conversion to Methyl Lactate by Sn Beta: Effects of Substrate Masking and of Water

Tosi, I., Riisager, A., Taarning, E., Jensen, P. R. & Meier, S., 2018, In : Catalysis Science & Technology. 18, 8, p. 2137-2145 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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148 Downloads (Pure)

Stable isotope-resolved analysis with quantitative dissolution dynamic nuclear polarization

Lerche, M. H., Yigit, D., Frahm, A. B., Ardenkjær-Larsen, J. H., Malinowski, R. M. & Jensen, P. R., 2018, In : Analytical chemistry. 90, 1, p. 674–678

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2017
172 Downloads (Pure)
Open Access
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60 Downloads (Pure)

Probing of biochemical pathways in clonal pancreatic β–cells by quantitative dDNP of metabolite extracts

Malinowski, R. M., Ghiasi, S. M., Mandrup-Poulsen, T., Jensen, P. R. & Ardenkjær-Larsen, J. H., 2017. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
File
18 Downloads (Pure)

Quantifying Biochemical Activities in Living Cells with 13C dDNP NMR

Jensen, P. R., Karlsson, M., Capozzi, A., Ardenkjær-Larsen, J. H. & Lerche, M. H., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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2016
20 Downloads (Pure)
193 Downloads (Pure)

Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

Jensen, P. R. & Meier, S., 2016, In : Chemical Communications. 52, p. 2288-2291 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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83 Downloads (Pure)

Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr

Lerche, M. H., Jensen, P. R., Karlsson, M., Napolitano, R., Cabella, C., Miragoli, L., Colombo Serra, S. & Tedoldi, F., 11 May 2016, IPC No. A61K 49/ 10 A I, Patent No. EP3016687, 8 Jan 2015, Priority date 30 Jun 2014, Priority No. WO2014EP63842

Research output: Patent

Open Access
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131 Downloads (Pure)

Probing treatment response of glutaminolytic prostate cancer cells to natural drugs with hyperpolarized [5-13C]glutamine

Jensen, P. R., Canape, C., Catanzaro, G., Karlsson, M. & Lerche, M. H., 2016. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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164 Downloads (Pure)
Open Access
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Spectroscopic approaches to resolving ambiguities of hyper-polarized NMR signals from different reaction cascades

Jensen, P. R. & Meier, S., 2016, In : Analyst. 141, 3, p. 823-826 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2015
77 Downloads (Pure)

3D metabolic ex vivo sample imaging of hyperpolarized compounds using a 3D single-shot RARE (3D SS-RARE) sequence, combining spectral RF selectivity with under-sampled spectral encoding at signal read-out

Magnusson, P. O., Jensen, P. R., Dyrby, T. B., Karlsson, M., Lerche, M. H. & Hanson, L. G., 2015, Proceedings of 5th hyperpolarization symposium. p. 105 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
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Hyperpolarized [1,3-C-13(2)]ethyl acetoacetate is a novel diagnostic metabolic marker of liver cancer

Jensen, P. R., Serra, S. C., Miragoli, L., Karlsson, M., Cabella, C., Poggi, L., Venturi, L., Tedoldi, F. & Lerche, M. H., 2015, In : International Journal of Cancer. 136, 4, p. E117-E126

Research output: Contribution to journalJournal articleResearchpeer-review

75 Downloads (Pure)

Hyperpolarized 2-oxoglutarate as metabolic agent in mr

Jensen, P. R., Karlsson, M., Lerche, M. H., Cabella, C., Caminiti, L., Colombo Serra, S., Miragoli, L., Poggi, L., Venturi, L. & Tedoldi, F., 2 Sep 2015, IPC No. A61K 49/ 10 A I, Patent No. EP2911704, 2 Sep 2015, Priority date 24 Oct 2013, Priority No. WO2013EP72269

Research output: Patent

Open Access
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42 Downloads (Pure)

Hyperpolarized amino acids

Karlsson, M., Lerche, M. H. & Jensen, P. R., 11 Feb 2015, IPC No. A61K 49/ 10 A I, Patent No. EP2833924, 11 Feb 2015, Priority date 28 Mar 2013, Priority No. WO2013EP56696

Research output: Patent

Open Access
File
44 Downloads (Pure)

Hyperpolarized esters as metabolic markers in mr

Jensen, P. R., Lerche, M. H., Karlsson, M., Cabella, C., Colombo Serra, S., Miragoli, L., Venturi, L. & Tedoldi, F., 9 Dec 2015, IPC No. A61K 49/ 10 A I, Patent No. EP2950826, 9 Dec 2015, Priority date 30 Jan 2014, Priority No. EP20140704304

Research output: Patent

Open Access
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33 Downloads (Pure)

Intra-operative cancer diagnosis based on a hyperpolarized marker

Lerche, M. H., Karlsson, M. & Jensen, P. R., 18 Mar 2015, IPC No. G01N 33/ 574 A I, Patent No. EP2847591, 18 Mar 2015, Priority date 7 May 2013, Priority No. WO2013EP59481

Research output: Patent

Open Access
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NMR Insights into the Inner Workings of Living Cells

Lerche, M. H., Jensen, P. R., Karlsson, M. & Meier, S., 2015, In : Analytical chemistry. 87, p. 119−132

Research output: Contribution to journalJournal articleResearchpeer-review

Probing treatment response of glutaminolytic prostate cancer cells to natural drugs with hyperpolarized [5-C-13]glutamine: Glutaminolysis to Measure Drug Response in Cancer Cells

Canape, C., Catanzaro, G., Terreno, E., Karlsson, M., Lerche, M. H. & Jensen, P. R., 2015, In : Magnetic Resonance in Medicine. 73, 6, p. 2296-2305

Research output: Contribution to journalJournal articleResearchpeer-review

28 Downloads (Pure)

Triarylmethyl radicals.

Karlsson, M., Napolitano, R., Visigalli, M., Lerche, M. H., Jensen, P. R. & Tedoldi, F., 20 May 2015, IPC No. G01R 33/ 62 A I, Patent No. EP2872520, 20 May 2015, Priority date 4 Jul 2013, Priority No. WO2013EP64121

Research output: Patent

Open Access
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2014
80 Downloads (Pure)

Hyperpolarized NMR Probes for Biological Assays

Meier, S., Jensen, P. R., Karlsson, M. & Lerche, M. H., 2014, In : Sensors. 14, 1, p. 1576-1597

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Non-invasive in-cell determination of free cytosolic [NAD+]/ [NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes

Christensen, C. E., Karlsson, M., Winther, J. R., Jensen, P. R. & Lerche, M. H., 2014, In : Journal of Biological Chemistry. 289, 4, p. 2344-2352

Research output: Contribution to journalJournal articleResearchpeer-review

34 Downloads (Pure)

Process for the preparation of hyperpolarized derivatives for use in mri analysis

Aime, S., Battista Giovenzana, G., Tedoldi, F., Jensen, P. R., Karlsson, M., Lerche, M. H. & Colombo Serra, S., 20 Aug 2014, IPC No. A61K 49/ 10 A I, Patent No. EP2766050, 20 Aug 2014, Priority date 11 Oct 2012, Priority No. WO2012EP70187

Research output: Patent

Open Access
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Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system

Habazettl, J., Allan, M., Jensen, P. R., Sass, H-J., Thompson, C. J. & Grzesiek, S., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. E5498-E5507

Research output: Contribution to journalJournal articleResearchpeer-review

2013
33 Downloads (Pure)

Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis.

Lerche, M. H., Karlsson, M., Jensen, P. R., Colombo Serra, S., Visigalli, M., Aime, S. & Tedoldi, F., 13 Jun 2013, IPC No. A61K 49/ 10 A I, Patent No. WO2013083535, 13 Jun 2013, Priority date 5 Dec 2011, Priority No. EP20110191872

Research output: Patent

Open Access
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In vivo and in vitro liver cancer metabolism observed with hyperpolarized [5-C-13]glutamine

Cabella, C., Karlsson, M., Canape, C., Catanzaro, G., Serra, S. C., Miragoli, L., Poggi, L., Uggeri, F., Venturi, L., Jensen, P. R., Lerche, M. H. & Tedoldi, F., 2013, In : Journal of Magnetic Resonance. 232, p. 45-52

Research output: Contribution to journalJournal articleResearchpeer-review

38 Downloads (Pure)

Process for preparing hyperpolarized substrates and method for mri

Aime, S., Battista Giovenzana, G., Tedoldi, F., Maiocchi, A., Uggeri, F., Jensen, P. R., Karlsson, M., Lerche, M. H., Visigalli, M., Crosetti, M. & Poggi, L., 13 Feb 2013, IPC No. A61K 49/ 10 A I, Patent No. EP2555803, 13 Feb 2013, Priority date 8 Apr 2011, Priority No. WO2011EP55485

Research output: Patent

Open Access
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WhiB7, an Fe-S-dependent Transcription Factor That Activates Species-specific Repertoires of Drug Resistance Determinants in Actinobacteria.

Ramón-García, S., Ng, C., Jensen, P. R., Dosanjh, M., Burian, J., Morris, R. P., Folcher, M., Eltis, L. D., Grzesiek, S., Nguyen, L. & Thompson, C. J., 2013, In : Journal of Biological Chemistry. 288, 48, p. 34514-34528

Research output: Contribution to journalJournal articleResearchpeer-review

2012

Development of Dissolution DNP-MR Substrates for Metabolic Research

Karlsson, M., Jensen, P. R., Duus, J. Ø., Meier, S. & Lerche, M. H., 2012, In : Applied Magnetic Resonance. 43, 1-2, p. 223-236

Research output: Contribution to journalJournal articleResearchpeer-review

Direct Observation of Metabolic Differences in Living Escherichia Coli Strains K-12 and BL21

Meier, S., Jensen, P. R. & Duus, J. Ø., 2012, In : ChemBioChem. 13, 2, p. 308-310 3 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Sulfite Action in Glycolytic Inhibition: In Vivo Real-Time Observation by Hyperpolarized 13C NMR Spectroscopy

Meier, S., Solodovnikova, N., Jensen, P. R. & Wendland, J., 2012, In : ChemBioChem. 13, 15, p. 2265-2269 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Metabolic pathway visualization in living yeast by DNP-NMR

Meier, S., Karlsson, M., Jensen, P. R., Lerche, M. H. & Duus, J. Ø., 2011, In : Molecular BioSystems. 7, 10, p. 2834-2836

Research output: Contribution to journalJournal articleResearchpeer-review

Quantitative dynamic nuclear polarization‐NMR on blood plasma for assays of drug metabolism

Lerche, M. H., Meier, S., Jensen, P. R., Hustvedt, SO., Karlsson, M., Duus, J. Ø. & Ardenkjær-Larsen, J. H., 2011, In : N M R in Biomedicine. 24, 1, p. 96-103

Research output: Contribution to journalJournal articleResearchpeer-review

Real-time detection of central carbon metabolism in living Escherichia coli and its response to perturbations

Meier, S., Jensen, P. R. & Duus, J. Ø., 2011, In : FEBS Letters. 585, 19, p. 3133-3138

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate

Karlsson, M., Jensen, P. R., in 't Zandt, R., Gisselsson, A., Hansson, G., Duus, J. Ø., Meier, S. & Lerche, M. H., 2010, In : International Journal of Cancer. 127, 3, p. 729-736

Research output: Contribution to journalJournal articleResearchpeer-review

33 Downloads (Pure)

Mr imaging agent or medium compressing hzperpolarised 13c alanine and methods of imaging wherein such an imaging medium is used.

Gisselsson, A., Hansson, G., Månsson, S., In't Zandt, R., Karlsson, M., Jensen, P. R. & Lerche, M. H., 13 Oct 2010, IPC No. G01N 33/ 50 A I, Patent No. EP2237801, 13 Oct 2010, Priority date 3 Feb 2009, Priority No. WO2009EP51174

Research output: Patent

Open Access
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Study of molecular interactions with 13C DNP-NMR

Lerche, M. H., Meier, S., Jensen, P. R., Baumann, H., Petersen, B. O., Karlsson, M., Duus, J. Ø. & Ardenkjær-Larsen, J. H., 2010, In : Journal of Magnetic Resonance. 203, 1, p. 52-56

Research output: Contribution to journalJournal articleResearchpeer-review

2009
21 Downloads (Pure)

Composition and method for generating a metabolic profile using 13c-mr detection

Gisselsson, A., Hansson, G., Maansson, S., Zandt, R., Karlsson, M., Jensen, P. R. & Lerche, M. H., 25 Jun 2009, IPC No. A61K 49/ 00 A I, Patent No. WO2009077575, 25 Jun 2009, Priority date 19 Dec 2007, Priority No. EP20070024585

Research output: Patent

Open Access
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Detection of low-populated reaction intermediates with hyperpolarized NMR

Jensen, P. R., Meier, S., Ardenkjær-Larsen, J. H., Duus, J. Ø., Karlsson, M. & Lerche, M. H., 2009, In : Chemical Communications. 2009, 34, p. 5168-5170

Research output: Contribution to journalJournal articleResearchpeer-review

Hyperpolarized Amino Acids for In Vivo Assays of Transaminase Activity

Jensen, P. R., Karlsson, M., Meier, S., Duus, J. Ø. & Lerche, M. H., 2009, In : Chemistry: A European Journal. 15, 39, p. 10010-10012

Research output: Contribution to journalJournal articleResearchpeer-review

19 Downloads (Pure)

Imaging medium comprising hyperpolarised 13c-acetate and use thereof

Gisselsson, A., Hansson, G., Maansson, S., Zandt, R., Karlsson, M., Jensen, P. R. & Lerche, M. H., 5 Mar 2009, IPC No. G01N 33/ 50 A I, Patent No. WO2009027388, 5 Mar 2009, Priority date 27 Aug 2007, Priority No. NO20070004367

Research output: Patent

Open Access
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