No photo of Pernille Harris
  • 206, 210

    Denmark

1995 …2022
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Research Output 1995 2020

2020

Characterization of native reversible self-association of a monoclonal antibody mediated by Fab-Fab interaction

Gentiluomo, L., Roessner, D., Streicher, W., Mahapatra, S., Harris, P. & Frieß, W., 2020, In : Journal of Pharmaceutical Sciences. 109, 1, p. 443-451

Research output: Contribution to journalJournal articleResearchpeer-review

Investigations of albumin-insulin detemir complexes using molecular dynamics simulations and free energy calculations

Ryberg, L. A., Sønderby, P., Bukrinski, J. T., Harris, P. & Peters, G. H. J., 2020, In : Molecular Pharmaceutics. 17, 1, p. 132-144

Research output: Contribution to journalJournal articleResearchpeer-review

Orthogonal techniques to study the effect of pH, sucrose and arginine salts on monoclonal antibody physical stability and aggregation during long-term storage

Svilenov, H. L., Kulakova, A., Zalar, M., Golovanov, A. P., Harris, P. & Winter, G., 2020, In : Journal of Pharmaceutical Sciences. 109, 1, p. 584-594

Research output: Contribution to journalJournal articleResearchpeer-review

13 Downloads (Pure)

Small angle X-ray scattering and molecular dynamic simulations provide molecular insight for stability of recombinant human transferrin

Kulakova, A., Indrakumar, S., Sønderby, P., Gentiluomo, L., Streicher, W., Roessner, D., Frieß, W., Peters, G. H. J. & Harris, P., 2020, In : Journal of Structural Biology: X. 4, 11 p., 100017.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2019

A Novel Niobium Cluster Aqua Ion with Capping μ4 -Se Ligand

Gushchin, A. L., Ooi, B. L., Harris, P., Abramov, P. A. & Sokolov, M. N., 2019, In : Zeitschrift fuer Anorganische und Allgemeine Chemie. 645, 4, p. 398-401 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

149 Downloads (Pure)

A pathogenic haplotype, common in Europeans, causes autosomal recessive albinism and uncovers missing heritability in OCA1

Grønskov, K., Jespersgaard, C., Bruun, G. H., Harris, P., Brøndum-Nielsen, K., Andresen, B. S. & Rosenberg, T., 2019, In : Scientific Reports. 9, 1, 7 p., 645.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Application of interpretable artificial neural networks to early monoclonal antibodies development

Gentiluomo, L., Roessner, D., Augustijn, D., Svilenov, H., Kulakova, A., Mahapatra, S., Winter, G., Streicher, W., Rinnan, Å., Peters, G. H. J., Harris, P. & Frieß, W., 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 141, p. 81-89 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Conformational Stability Study of a Therapeutic Peptide Plectasin Using Molecular Dynamics Simulations in Combination with NMR

Indrakumar, S., Zalar, M., Pohl, C., Nørgaard, A., Streicher, W., Harris, P., Golovanov, A. P. & Peters, G. H. J., 2019, In : Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 123, 23, p. 4867-4877 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

201 Downloads (Pure)

Solution structures of long-acting insulin analogues and their complexes with albumin

Ryberg, L. A., Sønderby, P., Barrientos, F., Bukrinski, J. T., Peters, G. H. J. & Harris, P., 2019, In : Acta crystallographica Section D: Structural biology . 75, 3, p. 272-282 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Structure-based Discovery of a new Protein-Aggregation Breaking Excipient

Tosstorff, A., Svilenov, H., Peters, G. H. J., Harris, P. & Winter, G., 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 144, p. 207-216 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Use of ¹⁹F Differential Labelling for the Simultaneous Detection and Monitoring of Three Individual Proteins in a Serum Environment

Edwards, J. M., Harris, P., Bukrinski, J. T. & Golovanov, A. P., 2019, In : ChemPlusChem. 84, 5, p. 443-446 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2018
139 Downloads (Pure)

Interaction between structurally different heteroexopolysaccharides and β-lactoglobulin studied by solution scattering and analytical ultracentrifugation

Khan, S., Birch, J., Van Calsteren, M-R., Ipsen, R., Peters, G. H. J., Svensson, B., Harris, P. & Almdal, K., 2018, In : International Journal of Biological Macromolecules. 111, p. 746-754 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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74 Downloads (Pure)

Revealing the Dimeric Crystal and Solution Structure of β-Lactoglobulin at pH 4 and Its pH and Salt Dependent Monomer–Dimer Equilibrium

Khan, S., Ipsen, R., Almdal, K., Svensson, B. & Harris, P., 2018, In : Biomacromolecules. 19, p. 2905-2912

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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144 Downloads (Pure)

Self-Interaction of Human Serum Albumin: A Formulation Perspective

Sønderby, P., Bukrinski, J. T., Hebditch, M., Peters, G. H. J., Curtis, R. A. & Harris, P., 2018, In : ACS Omega. 3, 11, p. 16105-16117 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2017
110 Downloads (Pure)

Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Hammershøj, P., Thyhaug, E., Harris, P., Ek, P. K., Andresen, T. L. & Clausen, M. H., 2017, In : Tetrahedron Letters. 58, 16, p. 1611-1615

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
184 Downloads (Pure)

Glucagon-like Peptide 1 Conjugated to Recombinant Human Serum Albumin Variants with Modified Neonatal Fc Receptor Binding Properties. Impact on Molecular Structure and Half-Life

Bukrinski, J. T., Sønderby, P., Antunes, F., Andersen, B., Schmidt, E. G. W., Peters, G. H. J. & Harris, P., 2017, In : Biochemistry. 56, 36, p. 4860-4870

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
619 Downloads (Pure)

Insulin fibrillation: The influence and coordination of Zn2+

Frankær, C. G., Sønderby, P., Bang, M. B., Mateiu, R. V., Groenning, M., Bukrinski, J. & Harris, P., 2017, In : Journal of Structural Biology. 199, 1, p. 27-38

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
50 Downloads (Pure)

Interaction between β-lactoglobulin and structurally different heteroexopolysaccharides investigated by solution scattering and analytical ultracentrifugation study

Khan, S., Birch, J., Harris, P., Van Calsteren, M-R., Ipsen, R., Peters, G. H. J., Svensson, B. & Almdal, K., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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137 Downloads (Pure)

Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase

Tidemand, K. D., Peters, G. H. J., Harris, P., Stensgaard, E. & Christensen, H. E. M., 2017, In : Biochemistry. 56, 46, p. 6155–6164

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Revealing the Compact Structure of Lactic Acid Bacterial Heteroexopolysaccharides by SAXS and DLS

Khan, S., Birch, J., Harris, P., Van Calsteren, M-R., Ipsen, R., Peters, G. H. J., Svensson, B. & Almdal, K., 2017, In : Biomacromolecules. 18, 3, p. 747-756

Research output: Contribution to journalJournal articleResearchpeer-review

194 Downloads (Pure)

Revealing the compact structure of lactic acid bacterial hetero-exopolysaccharides by SAXS and DLS

Khan, S., Birch, J., Harris, P., Van Calsteren, M-R., Ipsen, R., Peters, G. H. J., Svensson, B. & Almdal, K., 2017, In : Biomacromolecules. 18, 3, p. 747-757

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Small-Angle X-ray Scattering Data in Combination with RosettaDock Improves the Docking Energy Landscape

Sønderby, P., Rinnan, Å., Madsen, J. J., Harris, P., Bukrinski, J. T. & Peters, G. H. J., 2017, In : Journal of Chemical Information and Modeling. 57, 10, p. 2463-2475

Research output: Contribution to journalJournal articleResearchpeer-review

158 Downloads (Pure)

The structure of Lactococcus lactis thioredoxin reductase reveals molecular features of photo-oxidative damage

Skjoldager, N., Bang, M. B., Rykær, M., Björnberg, O., Davies, M. J., Svensson, B., Harris, P. & Hägglund, P., 2017, In : Scientific Reports. 7, 10 p., 46282.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2016

CYP1B1 Mutations in Individuals With Primary Congenital Glaucoma and Residing in Denmark

Grønskov, K., Redó-Riveiro, A., Sandfeld, L., Zibrandtsen, N., Harris, P., Bach-Holm, D. & Tümer, Z., 2016, In : Journal of Glaucoma. 25, 12, p. 926–930

Research output: Contribution to journalJournal articleResearchpeer-review

209 Downloads (Pure)

Stabilization of Tryptophan Hydroxylase 2 by L-Phenylalanine Induced Dimerization

Tidemand, K. D., Christensen, H. E. M., Hoeck, N., Harris, P., Boesen, J. & Peters, G. H. J., 2016, In : F E B S Open Bio. 6, 10, p. 987-999 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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290 Downloads (Pure)

The crystal structure of human dopamine  β-hydroxylase at 2.9 Å resolution

Vendelboe, T. V., Harris, P., Zhao, Y., Walter, T. S., Harlos, K., El Omari, K. & Christensen, H. E. M., 2016, In : Science Advances. 2, 4, 10 p., e1500980.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2015

Bacillus halodurans Strain C125 Encodes and Synthesizes Enzymes from Both Known Pathways To Form dUMP Directly from Cytosine Deoxyribonucleotides

Oehlenschlæger, C. B., Løvgreen, M. N., Reinauer, E., Lehtinen, E., Pind, M-L. L., Harris, P., Martinussen, J. & Willemoës, M., 2015, In : APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 81, 10, p. 3395-3404 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

175 Downloads (Pure)

Case report: a novel KERA mutation associated with cornea plana and its predicted effect on protein function

Roos, L., Bertelsen, B., Harris, P., Bygum, A., Jensen, H., Grønskov, K. & Tümer, Z., 2015, In : B M C Medical Genetics. 16, 6 p., 40.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Effects of thionation and fluorination on cis-trans isomerization in tertiary amides: An investigation of N -alkylglycine (Peptoid) rotamers

Engel-Andreasen, J., Wich, K., Laursen, J. S., Harris, P. & Olsen, C. A., 2015, In : Journal of Organic Chemistry. 80, 11, p. 5415-5427 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

222 Downloads (Pure)

Experimental and Theoretical Mechanistic Investigation of the Iridium-Catalyzed Dehydrogenative Decarbonylation of Primary Alcohols

Olsen, E. P. K., Singh, T., Harris, P., Andersson, P. G. & Madsen, R., 2015, In : Journal of the American Chemical Society. 137, 2, p. 834-842 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Facile Large-Scale Synthesis of 5- and 6-Carboxyfluoresceins: Application for the Preparation of New Fluorescent Dyes

Hammershøj, P., Ek, P. K., Harris, P., Andresen, T. L. & Clausen, M. H., 2015, In : European Journal of Organic Chemistry. 2015, 33, p. 7301-7309 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

124 Downloads (Pure)

Interactions of a Glucagon-like peptide 1 and a Glucagon-like peptide 1 analogue, liraglutide, with the endogenous receptor

Frederiksen, T. M., Harris, P., Bukrinski, JT. & Peters, G. H. J., 2015. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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Mutational analysis of divalent metal ion binding in the active site of class II α-mannosidase from sulfolobus solfataricus

Hansen, D. K., Webb, H., Nielsen, J. W., Winther, J. R., Willemoes, M. & Harris, P., 2015, In : Biochemistry. 54, 11, p. 2032-2039 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

605 Downloads (Pure)

Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations

Frederiksen, T. M., Sønderby, P., Ryberg, LA., Harris, P., Bukrinski, JT., Scharff-Poulsen, AM., Elf-Lind, M. N. & Peters, G. H. J., 2015, In : BIOPHYSICAL JOURNAL. 109, 6, p. 1202-1213 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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337 Downloads (Pure)

Remote Loading of 64Cu2+ into Liposomes without the Use of Ion Transport Enhancers

Henriksen, J. R., Petersen, A. L., Hansen, A. E., Frankær, C. G., Harris, P., Elema, D. R., Kristensen, A. T., Kjær, A. & Andresen, T. L., 2015, In : A C S Applied Materials and Interfaces. 7, 41, p. 22796-22806 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
186 Downloads (Pure)

Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds

Laursen, J. S., Harris, P., Fristrup, P. & Olsen, C. A., 2015, In : Nature Communications. 6, 10 p., 7013.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2014

Analysis of an industrial production suspension of Bacillus lentus subtilisin crystals by powder diffraction: a powerful quality-control tool

Frankær, C. G., Moroz, O. V., Turkenburg, J. P., Aspmo, S. I., Thymark, M., Friis, E. P., Ståhl, K., Nielsen, J. E., Wilson, K. S. & Harris, P., 2014, In : Acta Crystallographica. Section D: Biological Crystallography. 70, Part 4, p. 1115–1123

Research output: Contribution to journalJournal articleResearchpeer-review

Methyl Effect in Azumamides Provides Insight Into Histone Deacetylase Inhibition by Macrocycles

Maolanon, A., Villadsen, J., Christensen, N. J., Hoeck, C., Friis, T., Harris, P., Gotfredsen, C. H., Fristrup, P. & Olsen, C. A., 2014, In : Journal of Medicinal Chemistry. 57, 22, p. 9644–9657 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

60 Downloads (Pure)

X-ray powder diffraction: a powerful analysis tool for industrial protein production

Frankær, C. G., Thymark, M., Ståhl, K., Moroz, O. V., Wilson, K. S. & Harris, P., 2014. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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2013
3545 Downloads (Pure)

Cis–Trans Amide Bond Rotamers in β-Peptoids and Peptoids: Evaluation of Stereoelectronic: Effects in Backbone and Side Chains

Laursen, J. S., Engel-Andreasen, J., Fristrup, P., Harris, P. & Olsen, C. A., 2013, In : Journal of the American Chemical Society. 135, 7, p. 2835-2844

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
582 Downloads (Pure)

Monitoring protein precipitates by in-house X-ray powder diffraction

Ståhl, K., Frankær, C. G., Petersen, J. & Harris, P., 2013, In : Powder Diffraction. 28, SUPPL.2, p. S458-S469

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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313 Downloads (Pure)

Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A–E as Well as β2- epi-Azumamide E and β3-epi-Azumamide E

Villadsen, J., Stephansen, H. M., Maolanon, A., Harris, P. & Olsen, C. A., 2013, In : Open Journal of Medicinal Chemistry. 56, 16, p. 206512-6520

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2012

The structures of T6, T3R3 and R6 bovine insulin: combining X-ray diffraction and absorption spectroscopy

Frankær, C. G., Knudsen, M. V., Noren, K., Nazarenko, E., Ståhl, K. & Harris, P., 2012, In : Acta Crystallographica. Section D: Biological Crystallography. 68, p. 1259-1271

Research output: Contribution to journalJournal articleResearchpeer-review

2011
224 Downloads (Pure)

(+)-Geodin from Aspergillus terreus.

Rønnest, M. H., Nielsen, M. T., Leber, B., Mortensen, U. H., Krämer, A., Clausen, M. H., Larsen, T. O. & Harris, P., 2011, In : Acta Crystallographica. Section C: Crystal Structure Communications. 67, Pt 3, p. o125-o128

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
343 Downloads (Pure)

A sample holder for in-house X-ray powder diffraction studies of protein powders

Frankær, C. G., Harris, P. & Ståhl, K., 2011, In : Journal of Applied Crystallography. 44, 6, p. 1288-1290

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
309 Downloads (Pure)

CDIO Projects in DTU’s Chemical and Biochemical B.Eng. Study Program

Clement, K., Harris, P. & Agersø, Y., 2011, Proceedings of the 7th International CDIO Conference. Technical University of Denmark

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Open Access
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Crystal structures of the all-cysteinyl-coordinated D14C variant of Pyrococcus furiosus ferredoxin: [4Fe–4S] ↔ [3Fe–4S] cluster conversion

Løvgreen, M. N., Martic, M., Windahl, M. S., Christensen, H. E. M. & Harris, P., 2011, In : Journal of Biological Inorganic Chemistry. 16, 5, p. 763-775

Research output: Contribution to journalJournal articleResearchpeer-review

In-house characterization of protein powder

Hartmann, C. G., Harris, P. & Ståhl, K., 2011, In : Zeitschrift für Kristallographie Proceedings. 1-2, 1, p. 163-168

Research output: Contribution to journalConference articleResearchpeer-review