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With hyperpolarization techniques NMR signals of many different nuclei can be temporarily boosted with several orders of magnitudes. Dissolution DNP (dDNP) is one such hyperpolarization technique which has great versatility with respect to the hyperpolarization target (molecules or ions). My interest lies in developing applications for dDNP in biological and purely chemical systems with the aim of revealing new insights into metabolic or chemical pathways and kinetics. I’m also interested in expanding the field of dDNP by developing applications for nuclei other than 13C or 1H that are the most commonly employed in dDNP applications or investigations.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 7 Affordable and Clean Energy
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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ChipNMR: Hyperpolarized NMR for Noninvasive Metabolic Flux Analysis in Perfused Microfluidic Chips
Wareham Mathiassen, T. B., Sanchez-Heredia, J. D., Wang, K.-C., Haupt, C. R., Karlsson, M., Jonsson, A., Dufva, M., Thuenauer, R. & Jensen, P. R., 2026, In: Analytical Chemistry. 98, 3, p. 1891-1900Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamic 13C-MRI of Branched-Chain Amino Acid Metabolism Using Hyperpolarized [1-13C]2-Ketoisocaproate: A Multiband IDEAL Spiral Approach in Rodents and Pigs
Skre, I. S., Christensen, D. B., Karlsson, M., Ardenkjær-Larsen, J. H., Olin, R. B. & Lerche, M. H., 2026, (Accepted/In press) In: Magnetic Resonance in Medicine. 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Developing hyperpolarized metabolic contrast agents at high field dDNP for large animal research
Christensen, D. B., Skre, I. S., Ardenkjær-Larsen, J. H., Karlsson, M. & Lerche, M. H., 2025, In: Journal of Magnetic Resonance Open. 22, 7 p., 100184.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile153 Downloads (Orbit) -
Dynamic, multiphase magnetic resonance imaging of in vivo physiological processes with long-lived hyperpolarized 15N,d9-betaine
Skre, I. S., Karlsson, M., Sánchez-Heredia, J. D., Olin, R. B. & Lerche, M. H., 2025, In: Science Advances. 11, 27, 10 p., eadx8417.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile53 Downloads (Orbit) -
Hyperpolarized NMR Reveals Transient Species and Elusive Routes in Acid-Catalyzed Furfural Oxidation at Natural Isotope Abundance
Warthegau, S., Karlsson, M., Jensen, P. R. & Meier, S., 2025, In: Chemical Communications. 61, p. 3680-3683Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Downloads (Orbit)
Projects
- 2 Finished
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Chemical reactions and intermediates followed by DNP NMR
Boeg, P. A. (PhD Student), Mossin, S. (Main Supervisor), Ardenkjær-Larsen, J. H. (Supervisor), Duus, J. Ø. (Supervisor), Meier, S. (Examiner), Skrydstrup, T. (Examiner), Theis, T. (Examiner) & Karlsson, P. M. A. (Supervisor)
01/12/2015 → 19/08/2019
Project: PhD
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dDNP as a method to assess altered cellular metabolism in vitro
Malinowski, R. M. (PhD Student), Ardenkjær-Larsen, J. H. (Main Supervisor), Duus, J. Ø. (Supervisor), Jensen, P. R. (Supervisor), Karlsson, P. M. A. (Examiner), Giraudeau, P. (Examiner) & Sriram, R. (Examiner)
01/05/2015 → 23/01/2019
Project: PhD
Activities
- 3 Conference presentations
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Quantifying Biochemical Activities in Living Cells with 13C dDNP NMR
Lerche, M. H. (Invited speaker), Karlsson, M. (Other), Ardenkjær-Larsen, J. H. (Other), Jensen, P. R. (Other) & Capozzi, A. (Other)
24 Jul 2017Activity: Talks and presentations › Conference presentations
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Preparation of Radical-Free Hyperpolarized Water using Photo-induced non-persistent Radicals on a “SpinLab-like” dissolution-DNP Polarize
Capozzi, A. (Speaker), Coi, A. (Panel member), Karlsson, M. (Panel member), Lerche, M. H. (Guest lecturer) & Ardenkjær-Larsen, J. H. (Guest lecturer)
2 Jul 2017 → 6 Jul 2017Activity: Talks and presentations › Conference presentations
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A narrow line UV-induced non-persistent radical in view of generating highly polarized transportable glucose solid samples
Capozzi, A. (Guest lecturer), Coi, A. (Panel member), Patel, S. (Panel member), Ouari, O. (Panel member), Karlsson, M. (Guest lecturer), Lerche, M. H. (Guest lecturer), Comment, A. (Panel member) & Ardenkjær-Larsen, J. H. (Panel member)
2 Jul 2017 → 6 Jul 2017Activity: Talks and presentations › Conference presentations
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