• Kemitorvet, 204, 137

    2800 Kgs. Lyngby

    Denmark

1987 …2021
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Research Output 1987 2019

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Journal article
2019

A pentavalent vaccine for rainbow trout in Danish aquaculture

Marana, M. H., Sepulveda Araneda, D. A., Chen, D., Al-Jubury, A., Jaafar, R. M., Kania, P. W., Henriksen, N. H., Krossøy, B., Dalsgaard, I., Lorenzen, N. & Buchmann, K., 2019, In : Fish and Shellfish Immunology. 88, p. 344-351

Research output: Contribution to journalJournal articleResearchpeer-review

DNA vaccination for finfish aquaculture

Collins, C., Lorenzen, N. & Collet, B., 2019, In : Fish and Shellfish Immunology. 85, p. 106-125

Research output: Contribution to journalJournal articleResearchpeer-review

Pichia pastoris yeast as a vehicle for oral vaccination of larval and adult teleosts

Embregts, C. W. E., Reyes-Lopez, F., Pall, A. C., Stratmann, A., Tort, L., Lorenzen, N., Engell-Sorensen, K., Wiegertjes, G. F., Forlenza, M., Sunyer, J. O. & Parra, D., 1 Feb 2019, In : Fish and Shellfish Immunology. 85, p. 52-60

Research output: Contribution to journalJournal articleResearchpeer-review

59 Downloads (Pure)

Time-course study of the protection induced by an interferon-inducible DNA vaccine against viral haemorrhagic septicaemia in rainbow trout

Sepúlveda, D., Lorenzen, E., Rasmussen, J. S., Einer-Jensen, K., Collet, B., Secombes, C. J. & Lorenzen, N., 2019, In : Fish and Shellfish Immunology. 85, p. 99-105

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2018
1 Downloads (Pure)

Virulence marker candidates in N-protein of viral haemorrhagic septicaemia virus (VHSV): virulence variability within VHSV Ib clones

Ito, T., Kurita, J., Mori, K., Skall, H. F., Lorenzen, N., Vendramin, N., Andersen, N. G., Einer-Jensen, K. & Olesen, N. J., 2018, In : Diseases of Aquatic Organisms. 128, 1, p. 51-62 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2017
246 Downloads (Pure)

Intramuscular DNA Vaccination of Juvenile Carp against Spring Viremia of Carp Virus Induces Full Protection and Establishes a Virus-Specific B and T Cell Response

Embregts, C. W. E., Rigaudeau, D., Veselý, T., Pokorová, D., Lorenzen, N., Petit, J., Houel, A., Dauber, M., Schütze, H., Boudinot, P., Wiegertjes, G. F. & Forlenza, M., 2017, In : Frontiers in Immunology. 8, 1340.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2015

Involvement of two microRNAs in the early immune response to DNA vaccination against a fish rhabdovirus

Bela-ong, D. B., Schyth, B. D., Zou, J., Secombes, C. J. & Lorenzen, N., 2015, In : Vaccine. 33, 28, p. 3215-3222

Research output: Contribution to journalJournal articleResearchpeer-review

2014

High virulence differences among phylogenetically distinct isolates of the fish rhabdovirus viral hemorrhagic septicaemia virus are not explained by variability of the surface glycoprotein G or the non-virion protein Nv

Einer-Jensen, K., Harmache, A., Biacchesi, S., Bremont, M., Stegmann, A. & Lorenzen, N., 2014, In : Journal of General Virology. 95, Pt 2, p. 307-316

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Inter-species transmission of viral hemorrhagic septicemia virus (VHSV) from turbot (Scophthalmus maximus) to rainbow trout (Onchorhynchus mykiss)

Schönherz, A. A., Lorenzen, N. & Einer-Jensen, K., 2013, In : Journal of General Virology. 94, 4, p. 869-875

Research output: Contribution to journalJournal articleResearchpeer-review

2012
333 Downloads (Pure)

Determining Vaccination Frequency in Farmed Rainbow Trout Using Vibrio anguillarum O1 Specific Serum Antibody Measurements

Holten-Andersen, L., Dalsgaard, I., Nylén, J., Lorenzen, N. & Buchmann, K., 2012, In : P L o S One. 7, 11, p. e49672 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Efficacy of a glycoprotein DNA vaccine against viral haemorrhagic septicaemia (VHS) in Pacific herring, Clupea pallasii Valenciennes

Hart, L. M., Lorenzen, N., LaPatra, S. E., Grady, C. A., Roon, S. E., O’Reilly, J., Gregg, J. L. & Hershberger, P. K., 2012, In : Journal of Fish Diseases Online. 35, 10, p. 775-779

Research output: Contribution to journalJournal articleResearchpeer-review

439 Downloads (Pure)

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

Schyth, B. D., Bramsen, J. B., Pakula, M. M., Larashati, S., Kjems, J., Wengel, J. & Lorenzen, N., 2012, In : Nucleic Acids Research. 40, 10, p. 4653-4665

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Oral transmission as a route of infection for viral haemorrhagic septicaemia virus in rainbow trout, Oncorhynchus mykiss (Walbaum)

Schönherz, A. A., Hansen, M. H. H., Jørgensen, H. B. H., Berg, P., Lorenzen, N. & Einer-Jensen, K., 2012, In : Journal of Fish Diseases Online. 35, 6, p. 395-406

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Typing of viral hemorrhagic septicemia virus by monoclonal antibodies

Ito, T., Kurita, J., Sano, M., Skall, H. F., Lorenzen, N., Einer-Jensen, K. & Olesen, N. J., 2012, In : Journal of General Virology. 93, Pt 12, p. 2546-2557

Research output: Contribution to journalJournal articleResearchpeer-review

2011

General and family-specific gene expression responses to viral hemorrhagic septicaemia virus infection in rainbow trout (Oncorhynchus mykiss)

Jørgensen, H. B. H., Sørensen, P., Cooper, G. A., Lorenzen, E., Lorenzen, N., Hansen, M. H. H., Koop, B. F. & Henryon, M., 2011, In : Molecular Immunology. 48, 8, p. 1046-1058

Research output: Contribution to journalJournal articleResearchpeer-review

Rainbow trout surviving infections of viral haemorrhagic septicemia virus (VHSV) show lasting antibodies to recombinant G protein fragments

Encinas, P., Gomez-Casado, E., Grandes, F., Olesen, N. J., Lorenzen, N., Estepa, A. & Coll, J. M., 2011, In : Fish and Shellfish Immunology. 30, 3, p. 929-935

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Cellular and molecular immune responses of the sea bass (Dicentrarchus labrax) experimentally infected with betanodavirus

Scapigliati, G., Buonocore, F., Randelli, E., Casani, D., Meloni, S., Zarletti, G., Tiberi, M., Pietretti, D., Boschi, I., Manchado, M., Martin-Antonio, B., Jimenez-Cantizano, R., Bovo, G., Borghesan, F., Lorenzen, N., Einer-Jensen, K., Adams, S., Thompson, K., Alonso, C., Bejar, J. & 2 others, Borrego, J. J. & Alvarez, M. C., 2010, In : Fish and Shellfish Immunology. 28, p. 303-311

Research output: Contribution to journalJournal articleResearchpeer-review

Immersion exposure of rainbow trout (Oncorhynchus mykiss) fry to wildtype Flavobacterium psychrophilum induces no mortality, but protects against later intraperitoneal challenge

Lorenzen, E., Brudeseth, B. E., Wiklund, T. & Lorenzen, N., 2010, In : Fish and Shellfish Immunology. 28, 3, p. 440-444

Research output: Contribution to journalJournal articleResearchpeer-review

2009

Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection

Einer-Jensen, K., Delgado, L., Lorenzen, E., Bovo, G., Evensen, Ø., LaPatra, S. & Lorenzen, N., 2009, In : Vaccine. 27, 8, p. 1248-1253

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic and serological typing of European infectious haematopoietic necrosis virus (IHNV) isolates

Johansson, T., Einer-Jensen, K., Batts, W., Ahrens, P., Kurath, G., Björklund, H. & Lorenzen, N., 2009, In : Diseases of Aquatic Organisms. 86, 3, p. 213-221

Research output: Contribution to journalJournal articleResearchpeer-review

New tools to study RNA interference to fish viruses: Fish cell lines permanently expressing siRNAs targeting the viral polymerase of viral hemorrhagic septicemia virus

Ruiz, S., Schyth, B. D., Encinas, P., Tafalla, C., Estepa, A., Lorenzen, N. & Coll, J., 2009, In : Antiviral Research. 82, 3, p. 148-156

Research output: Contribution to journalJournal articleResearchpeer-review

The protective mechanisms induced by a fish rhabdovirus DNA vaccine depend on temperature

Lorenzen, E., Einer-Jensen, K., Rasmussen, J. S., Kjær, T. E., Collet, B., Secombes, C. J. & Lorenzen, N., 2009, In : Vaccine. 27, 29, p. 3870-3880

Research output: Contribution to journalJournal articleResearchpeer-review

2008

Cell-mediated immune responses in rainbow trout after DNA immunization against the viral hemorrhagic septicemia virus

Utke, K., Kock, H., Schuetze, H., Bergmann, S. M., Lorenzen, N., Einer-Jensen, K., Köllner, B., Dalmo, R. A., Vesely, T., Ototake, M. & Fischer, U., 2008, In : Developmental & Comparative Immunology. 32, 3, p. 239-252

Research output: Contribution to journalJournal articleResearchpeer-review

Regnbueørredens redning

Vinge, T. & Lorenzen, N., 2008, In : Dynamo. 12, p. 28-31

Research output: Contribution to journalJournal articleCommunication

2007

A High Throughput In Vivo Model for Testing Delivery and Antiviral Effects of siRNAs in Vertebrates

Schyth, B. D., Lorenzen, N. & Pedersen, F. S., 2007, In : Molecular Therapy. 15, 7, p. 1366-72

Research output: Contribution to journalJournal articleResearchpeer-review

Cell-mediated cytotoxicity in rainbow trout, Oncorhynchus mykiss, infected with viral haemorrhagic septicaemia virus

Utke, K., Bergmann, S., Lorenzen, N., Kollner, B., Ototake, M. & Fischer, U., 2007, In : Fish and Shellfish Immunology. 22, 3, p. 182-196

Research output: Contribution to journalJournal articleResearchpeer-review

2006

Antiviral activity of Small interfering RNAs: Specificity testing using heterologous virus reveals interferon-related effects overlooked by conventional mismatch controls

Schyth, B. D., Lorenzen, N. & Pedersen, F. S., 2006, In : Virology. 349, 1, p. 134-141

Research output: Contribution to journalJournal articleResearchpeer-review

Expression of the glycoprotein of viral haemorrhagic septicaemia virus (VHSV) on the surface of the fish cell line RTG-P1 induces type 1 interferon expression in neighbouring cells

Acosta, F., Collet, B., Lorenzen, N. & Ellis, A. E., 2006, In : Fish & shellfish immunology. 21, 3, p. 272-278

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic stability of the VHSV consensus sequence of G-gene in diagnostic samples from an acute outbreak

Einer-Jensen, K., Ahrens, P. & Lorenzen, N., 2006, In : Bulletin of The European Association of Fish Pathologists. 26, 2, p. 62-67

Research output: Contribution to journalJournal articleResearchpeer-review

Monitoring of the immune system in fish and shellfish

Lorenzen, N., Evensen, O., Cunningham, C., Scapigliati, G., Alvarez, M. C., Roch, P., Wiegertjes, G., Buchmann, K. & Adams, A., 2006, In : Bulletin of The European Association of Fish Pathologists. 26, 1, p. 48-49

Research output: Contribution to journalJournal articleResearchpeer-review

2005

DNA vaccines for aquacultured fish

Lorenzen, N. & LaPatra, S. E., 2005, In : Revue Scientifique Et Technique-office International Des Epizooties. 24, 1, p. 201-213

Research output: Contribution to journalJournal articleResearchpeer-review

Genotyping of the fish rhabdovirus, viral haemorrhagic septicaemia virus, by restriction fragment length polymorphisms

Einer-Jensen, K., Winton, J. & Lorenzen, N., 2005, In : Veterinary Microbiology. 106, 3-4, p. 167-178

Research output: Contribution to journalJournal articleResearchpeer-review

Kinetics of Mx expression in rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar L.) parr in response to VHS-DNA vaccination

Acosta, F., Petrie, A., Lockhart, K., Lorenzen, N. & Ellis, A. E., 2005, In : Fish & shellfish immunology. 18, 1, p. 81-89

Research output: Contribution to journalJournal articleResearchpeer-review

Parallel phylogenetic analyses using the N, G or Nv gene from a fixed group of VHSV isolates reveal the same overall genetic typing

Einer-Jensen, K., Ahrens, P. & Lorenzen, N., 2005, In : Diseases of Aquatic Organisms. 67, 1-2, p. 39-45

Research output: Contribution to journalJournal articleResearchpeer-review

Time course study of in situ expression of antigens following DNA-vaccination against VHS in rainbow trout (Oncorhynchus mykiss Walbaum) fry

Lorenzen, E., Lorenzen, N., Einer-Jensen, K., Brudeseth, B. & Evensen, O., 2005, In : Fish & shellfish immunology. 19, 1, p. 27-41

Research output: Contribution to journalJournal articleResearchpeer-review

2004

Evolution of the fish rhabdovirus viral haemorrhagic septicaemia virus

Einer-Jensen, K., Ahrens, P., Forsberg, R. & Lorenzen, N., 2004, In : Journal of General Virology. 85, 5, p. 1167-1179

Research output: Contribution to journalJournal articleResearchpeer-review

Use of plasmid DNA for induction of protective immunity

Lorenzen, N., 2004, In : Bulletin of The European Association of Fish Pathologists. 24, 1, p. 11-15

Research output: Contribution to journalJournal articleResearch

2003

A DNA vaccine directed against a rainbow trout rhabdovirus induces early protection against a nodavirus challenge in turbot

Sommerset, I., Lorenzen, E., Lorenzen, N., Bleie, H. & Nerland, A. H., 2003, In : Vaccine. 21, 32, p. 4661-4667

Research output: Contribution to journalJournal articleResearchpeer-review

DNA vaccination against viral haemorrhagic septicaemia (VHS) in rainbow trout: size, dose, route of injection and duration of protection-early protection correlates with Mx expression

McLauchlan, P. E., Collet, B., Ingerslev, E., Secombes, C. J., Lorenzen, N. & Ellis, A. E., 2003, In : Fish & shellfish immunology. 15, 1, p. 39-50

Research output: Contribution to journalJournal articleResearchpeer-review

2002

Immunity induced shortly after DNA vaccination of rainbow trout against rhabdoviruses protects against heterologous virus but not against bacterial pathogens

Lorenzen, N., Lorenzen, E., Einer-Jensen, K. & LaPatra, S. E., 2002, In : Developmental and Comparative Immunology. 26, 2, p. 173-179

Research output: Contribution to journalJournal articleResearchpeer-review

2001

Immunity to viral haemorrhagic septicaemia (VHS) following DNA vaccination of rainbow trout at an early life-stage

Lorenzen, N., Lorenzen, E. & Einer-Jensen, K., 2001, In : Fish & shellfish immunology. 11, 7, p. 585-591

Research output: Contribution to journalJournal articleResearchpeer-review

Neutralisation and binding of VHS virus by monovalent antibody fragments

Cupit, P. M., Lorenzen, N., Strachan, G., Kemp, G. J. L., Secombes, C. J. & Cunningham, C., 2001, In : Virus Research. 81, 1-2, p. 47-56

Research output: Contribution to journalJournal articleResearchpeer-review

Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination

LaPatra, S. E., Corbeil, S., Jones, G. R., Shewmaker, W. D., Lorenzen, N., Anderson, E. D. & Kurath, G., 2001, In : Vaccine. 19, 28-29, p. 4011-4019

Research output: Contribution to journalJournal articleResearchpeer-review

Rainbow trout offspring with different resistance to viral haemorrhagic septicaemia

Slierendrecht, W. J., Olesen, N. J., Juul-Madsen, H. R., Lorenzen, N., Henryon, M., Berg, P., Søndergaard, J. & Koch, C., 2001, In : Fish & shellfish immunology. 11, 2, p. 155-167

Research output: Contribution to journalJournal articleResearchpeer-review

2000

DNA vaccination of rainbow trout against viral hemorrhagic septicemia virus: A dose-response and time-course study

Lorenzen, E., Einer-Jensen, K., Martinussen, T., LaPatra, S. E. & Lorenzen, N., 2000, In : Journal of Aquatic Animal Health. 12, 3, p. 167-180

Research output: Contribution to journalJournal articleResearchpeer-review

Immunoprophylaxis in fish by injection of mouse antibody genes

Lorenzen, N., Cupit, P. M., Einer-Jensen, K., Lorenzen, E., Ahrens, P., Secombes, C. J. & Cunningham, C., 2000, In : Nature Biotechnology. 18, 11, p. 1177-1180

Research output: Contribution to journalJournal articleResearchpeer-review

Three monoclonal antibodies to the VHS virus glycoprotein: comparison of reactivity in relation to differences in immunoglobulin variable domain gene sequences

Lorenzen, N., Cupit, P. M., Secombes, C. J. & Cunningham, C., 2000, In : Fish & shellfish immunology. 10, 2, p. 129-142

Research output: Contribution to journalJournal articleResearchpeer-review

1999

Immunity to rhabdoviruses in rainbow trout: the antibody response

Lorenzen, N. & Lapatra, S. E., 1999, In : Fish & shellfish immunology. 9, 4, p. 345-360

Research output: Contribution to journalJournal articleResearchpeer-review