Publications per year
Publications per year
Personal profile
Profile
My research is strongly anchored on development of biomarkers, methods and equipment to enhance the utility of hyperpolarized metabolic contrast agents for in cell and in vivo magnetic resonance investigations. A central interest is understanding and finding effective solutions to the fundamental challenge of hyperpolarization – the short signal life-time. The conducted research is particularly tuned in on the field of biotechnology where technical engineering solutions, theoretical physics translated into practice and further optimized chemistry and biological application in recent years has led on studies of complex pathologies aiming at early diagnosis and monitoring of therapeutic effects.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Formate Metabolism in Shigella flexneri and Its Effect on HeLa Cells at Different Stages during the Infectious Process
Wang, K-C., Lerche, M. H., Ardenkjaer-Larsen, J. H. & Jensen, P. R., 2023, (Accepted/In press) In: Microbiology Spectrum. 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile20 Downloads (Pure) -
Quantitative Evaluation of the Cellular Uptake of Nanodiamonds by Monocytes and Macrophages
Niora, M., Lerche, M. H., Dufva, M. & Berg-Sørensen, K., 2023, (Accepted/In press) In: Small. 10 p., 2205429.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile16 Downloads (Pure) -
Classification and biomarker identification of prostate tissue from TRAMP mice with hyperpolarized 13C-SIRA
Frahm, A. B., Hill, D., Katsikis, S., Andreassen, T., Ardenkjær-Larsen, J. H., Bathen, T. F., Moestue, S. A., Jensen, P. R. & Lerche, M. H., 1 Dec 2021, In: Talanta. 235, 23 p., 122812.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
Measuring glycolytic activity with hyperpolarized [2H7, U‐13C6] d‐glucose in the naive mouse brain under different anesthetic conditions
Flatt, E., Lanz, B., Pilloud, Y., Capozzi, A., Lerche, M. H., Gruetter, R. & Mishkovsky, M., Jul 2021, In: Metabolites. 11, 7, 18 p., 413.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile48 Downloads (Pure) -
Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization
Capozzi, A., Kilund, J., Karlsson, M., Patel, S., Pinon, A. C., Vibert, F., Ouari, O., Lerche, M. H. & Ardenkjaer-Larsen, J. H., 2021, In: Communications Chemistry. 4, 1, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile48 Downloads (Pure)
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Translation of hyperpolarized metabolic brain imaging ¿ Investigation of a new combined HP 13C and 2H probe
Jacobsen, K. P., Lerche, M. H. & Olin, R. B.
01/12/2022 → 30/11/2025
Project: PhD
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Hyperpolarized MR ofmetabolism in porcine brain
Skre, I. S., Lerche, M. H. & Olin, R. B.
15/09/2022 → 14/09/2025
Project: PhD
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Diamond based sensing in single cells
Niora, M., Berg-Sørensen, K., Dufva, M. & Lerche, M. H.
Independent Research Fund Denmark
01/01/2021 → 28/10/2024
Project: PhD
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Deranged Neurometabolism in Alzheimer's with Hyperpolarized Magnetic Resonance
Christensen, D. B., Lerche, M. H., Ardenkjær-Larsen, J. H., Chuang, K. & Reutens, D. C.
15/09/2020 → 14/04/2024
Project: PhD
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Metabolomics using Dissolution DNP-NMR
Frahm, A., Giraudeau, P., Karlsson, P. M. A., Lerche, M. H., Jensen, P. R. & Elena-Herrmann, B.
01/01/2018 → 12/08/2021
Project: PhD
Activities
- 3 Conference presentations
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A narrow line UV-induced non-persistent radical in view of generating highly polarized transportable glucose solid samples
Andrea Capozzi (Guest lecturer), Alessandro Coi (Panel member), S Patel (Panel member), Olivier Ouari (Panel member), Magnus Karlsson (Guest lecturer), Mathilde Hauge Lerche (Guest lecturer), Arnaud Comment (Panel member) & Jan Henrik Ardenkjær-Larsen (Panel member)
2 Jul 2017 → 6 Jul 2017Activity: Talks and presentations › Conference presentations
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Preparation of Radical-Free Hyperpolarized Water using Photo-induced non-persistent Radicals on a “SpinLab-like” dissolution-DNP Polarize
Andrea Capozzi (Speaker), Alessandro Coi (Panel member), Magnus Karlsson (Panel member), Mathilde Hauge Lerche (Guest lecturer) & Jan Henrik Ardenkjær-Larsen (Guest lecturer)
2 Jul 2017 → 6 Jul 2017Activity: Talks and presentations › Conference presentations
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Quantifying Biochemical Activities in Living Cells with 13C dDNP NMR
Mathilde Hauge Lerche (Invited speaker), Magnus Karlsson (Other), Jan Henrik Ardenkjær-Larsen (Other), Pernille Rose Jensen (Other) & Andrea Capozzi (Other)
24 Jul 2017Activity: Talks and presentations › Conference presentations
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