Research output per year
Research output per year
Personal profile
Profile
My research is strongly anchored on development of biomarkers, methods and equipment to enhance the utility of hyperpolarized metabolic contrast agents for in cell and in vivo magnetic resonance investigations. A central interest is understanding and finding effective solutions to the fundamental challenge of hyperpolarization – the short signal life-time. The conducted research is particularly tuned in on the field of biotechnology where technical engineering solutions, theoretical physics translated into practice and further optimized chemistry and biological application in recent years has led on studies of complex pathologies aiming at early diagnosis and monitoring of therapeutic effects.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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A hybrid setup for rodent hyperpolarized metabolic imaging using a clinical magnetic resonance scanner
Christensen, D. B., Skre, I. S., Ardenkjær-Larsen, J. H., Mishkovsky, M. & Lerche, M. H., 2025, In: Journal of Magnetic Resonance Open. 22, 9 p., 100190.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile -
Developing hyperpolarized metabolic contrast agents at high field dDNP for large animal research
Christensen, D. B., Skre, I. S., Ardenkjær-Larsen, J. H., Karlsson, M. & Lerche, M. H., 2025, In: Journal of Magnetic Resonance Open. 22, 7 p., 100184.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Downloads (Orbit) -
A continuous flow bioreactor system for high-throughput hyperpolarized metabolic flux analysis
Christensen, N. V., Holm, R., Sanchez, J. D., Hansen, E. S. S., Lerche, M. H., Ardenkjær-Larsen, J. H., Laustsen, C. & Bertelsen, L. B., 2024, In: NMR in Biomedicine. 37, 5, 14 p., e5107.Research output: Contribution to journal › Journal article › Research › peer-review
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Adapting a 3T Clinical MRI for Hyperpolarized 13C Mouse Brain Imaging
Christensen, D. B., Skre, I. S., Frederiksen, A. S., Mishkovsky, M. & Lerche, M. H., 2024.Research output: Contribution to conference › Poster › Research › peer-review
Open AccessFile46 Downloads (Orbit) -
Adapting a 3T clinical MRI scanner for mouse brain hyperpolarized 13C MR imaging
Christensen, D. B., Skre, I. S., Mishkovsky, M. & Lerche, M. H., 2024.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Open AccessFile26 Downloads (Orbit)
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Translation of hyperpolarized metabolic brain imaging ¿ Investigation of a new combined HP 13C and 2H probe
Jacobsen, K. P. (PhD Student), Lerche, M. H. (Main Supervisor) & Olin, R. B. (Supervisor)
01/12/2022 → 30/07/2026
Project: PhD
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Hyperpolarized MR ofmetabolism in porcine brain
Skre, I. S. (PhD Student), Lerche, M. H. (Main Supervisor) & Olin, R. B. (Supervisor)
15/09/2022 → 14/09/2025
Project: PhD
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Diamond based sensing in single cells
Niora, M. (PhD Student), Berg-Sørensen, K. (Main Supervisor), Dufva, M. (Supervisor), Lerche, M. H. (Supervisor), Cigler, P. (Examiner) & Simpson, D. (Examiner)
Independent Research Fund Denmark
01/01/2021 → 11/03/2025
Project: PhD
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Deranged Neurometabolism in Alzheimer's with Hyperpolarized Magnetic Resonance
Christensen, D. B. (PhD Student), Lerche, M. H. (Main Supervisor), Mishkovsky, M.-M. (Supervisor), Chaumeil, M. (Examiner) & Kettunen, M. (Examiner)
15/09/2020 → 11/03/2025
Project: PhD
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Metabolomics using Dissolution DNP-NMR
Frahm, A. (PhD Student), Giraudeau, P. (Examiner), Karlsson, P. M. A. (Examiner), Lerche, M. H. (Main Supervisor), Jensen, P. R. (Supervisor) & Elena-Herrmann, B. (Examiner)
01/01/2018 → 12/08/2021
Project: PhD
Activities
- 3 Conference presentations
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Quantifying Biochemical Activities in Living Cells with 13C dDNP NMR
Lerche, M. H. (Invited speaker), Karlsson, M. (Other), Ardenkjær-Larsen, J. H. (Other), Jensen, P. R. (Other) & Capozzi, A. (Other)
24 Jul 2017Activity: Talks and presentations › Conference presentations
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Preparation of Radical-Free Hyperpolarized Water using Photo-induced non-persistent Radicals on a “SpinLab-like” dissolution-DNP Polarize
Capozzi, A. (Speaker), Coi, A. (Panel member), Karlsson, M. (Panel member), Lerche, M. H. (Guest lecturer) & Ardenkjær-Larsen, J. H. (Guest lecturer)
2 Jul 2017 → 6 Jul 2017Activity: Talks and presentations › Conference presentations
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A narrow line UV-induced non-persistent radical in view of generating highly polarized transportable glucose solid samples
Capozzi, A. (Guest lecturer), Coi, A. (Panel member), Patel, S. (Panel member), Ouari, O. (Panel member), Karlsson, M. (Guest lecturer), Lerche, M. H. (Guest lecturer), Comment, A. (Panel member) & Ardenkjær-Larsen, J. H. (Panel member)
2 Jul 2017 → 6 Jul 2017Activity: Talks and presentations › Conference presentations
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