Mads Hartvig Clausen

2024

Chemical synthesis and immunological evaluation of cancer vaccines based on ganglioside antigens and α-galactosylceramide

Romanò, C., Jiang, H., Tahvili, S., Wei, P., Keiding, U. B., Clergeaud, G., Skovbakke, S. L., Blomberg, A. L., Hafkenscheid, L., Henriksen, J. R., Andresen, T. L., Goletz, S., Hansen, A. E., Christensen, D. & Clausen, M. H., 2024, In: Rsc Medicinal Chemistry. 15, 8, p. 2718-2728

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Chemical synthesis of natural and azido-modified UDP-rhamnose and -arabinofuranose for glycan array-based characterization of plant glycosyltransferases

Pasini, I., Ruprecht, C., Osswald, U., Bittmann, A., Maltrovsky, L., Romanò, C., Clausen, M. H. & Pfrengle, F., 2024, In: Chemical Communications. 60, 70, p. 9368-9371 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2023

Differences in Human and Mouse Immunological Evaluation of Cancer Vaccines Based on Ganglioside Antigens and α-Galactosylceramide

Skovbakke, S. L., Blomberg, A. L., Hafkenscheid, L., Romano, C., Jiang, H., Tahvili, S., Wei, P., Henriksen, J. R., Hansen, A. E., Clausen, M. H. & Goletz, S., 2023, In: Glycobiology. 33, 11, p. 1011-1011 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Small-molecule modulators of tumor necrosis factor signaling

Chédotal, H., Narayanan, D., Povlsen, K., Gotfredsen, C. H., Brambilla, R., Gajhede, M., Bach, A. & Clausen, M. H., 2023, In: Drug Discovery Today. 28, 6, 9 p., 103575.

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Sulochrins and alkaloids from a fennel endophyte Aspergillus sp. FVL2

Shaaban, M., Abdel-Razek, A. S., Previtali, V., Clausen, M. H., Gotfredsen, C. H., Laatsch, H. & Ding, L., 2023, In: Natural Product Research. 37, 8, p. 1310-1320 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2022

A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B

Haidar, A. K., Kjeldsen, N. D., Troelsen, N. S., Previtali, V., Lundquist, K. P., Larsen, T. O. & Clausen, M. H., 2022, In: Molecules. 27, 2, 9 p., 521.

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Chemical Biology of αGalCer: A Chemist’s Toolbox for the Stimulation of Invariant Natural Killer T (iNKT) Cells

Romanò, C. & Clausen, M. H., 2022, In: European Journal of Organic Chemistry. 2022, 26, 19 p., e202200246.

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Cyclic Citrullinated Peptide Aptamer Treatment Attenuates Collagen Induced Arthritis

Khatri, S., Hansen, J., Pedersen, N., Gram-Nielsen, S., Mendes, A., Chronakis, I., Keiding, U., Rethi, B., Clausen, M. H., Kragstrup, T. W. & Astakhova, K., 2022, In: Annals of the Rheumatic Diseases. 81, Suppl. 1, p. 466-466

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Cyclic Citrullinated Peptide Aptamer Treatment Attenuates Collagen-Induced Arthritis

Khatri, S., Hansen, J., Pedersen, N. B., Brandt-Clausen, I. P., Gram-Nielsen, S., Mendes, A. C., Chronakis, I. S., Keiding, U. B., Catrina, A. I., Rethi, B., Clausen, M. H., Kragstrup, T. & Astakhova, K., 2022, In: Biomacromolecules. 23, 5, p. 2126-2137 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening

Lee, S.-W., Tran, K. T., Vazquez-Uribe, R., Gotfredsen, C. H., Clausen, M. H., Mendez, B. L., Montoya, G., Bach, A. & Sommer, M. O. A., 2022, In: Journal of Medicinal Chemistry. 65, 4, p. 3266–3305 40 p.

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Synthesis and evaluation of hydrogen peroxide sensitive tofacitinib prodrugs

Previtali, V., Keiding, U. B., Olsen, A. H., Peiró Cadahía, J., Clausen, A. S., Kjaer, A., Andresen, T. L., Hansen, A. E. & Clausen, M. H., 2022, In: European Journal of Medicinal Chemistry Reports. 4, 8 p., 100019.

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Targeting undruggable carbohydrate recognition sites through focused fragment library design

Shanina, E., Kuhaudomlarp, S., Siebs, E., Fuchsberger, F. F., Denis, M., Gomes, P. D. S. F. C., Clausen, M. H., Seeberger, P. H., Rognan, D., Titz, A., Imberty, A. & Rademacher, C., 2022, In: Communications Chemistry. 5, 1, 11 p., 64.

Research output: Contribution to journal › Letter › peer-review

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2021

ABCG transporters export cutin precursors for the formation of the plant cuticle

Elejalde-Palmett, C., Martinez San Segundo, I., Garroum, I., Charrier, L., De Bellis, D., Mucciolo, A., Guerault, A., Liu, J., Zeisler-Diehl, V., Aharoni, A., Schreiber, L., Bakan, B., Clausen, M. H., Geisler, M. & Nawrath, C., 2021, In: Current Biology. 31, 10, p. 2111-2123.e9

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A pipeline towards the biochemical characterization of the arabidopsis gt14 family

Xuan, L., Zhang, J., Lu, W., Gluza, P., Ebert, B., Kotake, T., Lu, M., Zhang, Y., Clausen, M. H., Johnson, K. L., Doblin, M. S., Heazlewood, J. L., Bacic, A., Song, L. & Zeng, W., 2021, In: International Journal of Molecular Sciences . 22, 3, 22 p., 1360.

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Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans

Muderspach, S. J., Fredslund, F., Volf, V., Poulsen, J.-C. N., Blicher, T. H., Clausen, M. H., Rasmussen, K. K., Krogh, K. B. R. M., Jensen, K. & Lo Leggio, L., 2021, In: Biotechnology for Biofuels. 14, 1, 16 p., 183.

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Fragment-based drug discovery for RNA targets

Lundquist, K. P., Panchal, V., Gotfredsen, C. H., Brenk, R. & Clausen, M. H., 2021, In: ChemMedChem. 16, 17, p. 2588-2603 16 p.

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Rhamnogalacturonan II - Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo

Mancuso, E., Romanò, C., Trattnig, N., Gritsch, P., Kosma, P. & Clausen, M. H., 2021, In: Chemistry - A European Journal. 27, 24, p. 7099-7102

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Small-Molecule Inhibitors of Reactive Oxygen Species Production

Sassetti, E., Clausen, M. H. & Laraia, L., 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 5252-5275 24 p.

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2020

A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases

Ruprecht, C., Bartetzko, M. P., Senf, D., Lakhina, A., Smith, P. J., Soto, M. J., Oh, H., Yang, J.-Y., Chapla, D., Silva, D. V., Clausen, M. H., Hahn, M. G., Moremen, K. W., Urbanowicz, B. R. & Pfrengle, F., 2020, In: Angewandte Chemie. 132, p. 12593-1259

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A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases

Ruprecht, C., Bartetzko, M. P., Senf, D., Lakhina, A., Smith, P. J., Soto, M. J., Oh, H., Yang, J.-Y., Chapla, D., Silva, D. V., Clausen, M. H., Hahn, M. G., Moremen, K. W., Urbanowicz, B. R. & Pfrengle, F., 2020, In: Angewandte Chemie International Edition. 59, 30, p. 12493–12498

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Auxiliary in vitro and in vivo biological evaluation of hydrogen peroxide sensitive prodrugs of methotrexate and aminopterin for the treatment of rheumatoid arthritis

Previtali, V., Petrovic, K., Peiro Cadahía, J., Troelsen, N. S. & Clausen, M. H., 2020, In: Bioorganic & Medicinal Chemistry. 28, 2, 115247.

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Azodyrecins A-C: Azoxides from a Soil-Derived Streptomyces Species

Wibowo, M., Gotfredsen, C. H., Sassetti, E., Melchiorsen, J., Clausen, M. H., Gram, L. & Ding, L., 2020, In: Journal of Natural Products. 83, 12, p. 3519-3525 7 p.

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Frontispiece: The 3F Library: Fluorinated Fsp3‐Rich Fragments for Expeditious ¹⁹F NMR Based Screening

Troelsen, N. S., Shanina, E., Gonzalez‐Romero, D., Danková, D., Jensen, I. S. A., Śniady, K. J., Nami, F., Zhang, H., Rademacher, C., Cuenda, A., Gotfredsen, C. H. & Clausen, M. H., 2020, In: Angewandte Chemie International Edition. 59, 6, p. 2204-2204

Research output: Contribution to journal › Journal article › Communication

Frontispiz: The 3F Library: Fluorinated Fsp³ ‐Rich Fragments for Expeditious ¹⁹F NMR Based Screening

Troelsen, N. S., Shanina, E., Gonzalez‐Romero, D., Danková, D., Jensen, I. S. A., Śniady, K. J., Nami, F., Zhang, H., Rademacher, C., Cuenda, A., Gotfredsen, C. H. & Clausen, M. H., 2020, In: Chemistry - A European Journal. 132, 6, p. 2224-2224

Research output: Contribution to journal › Journal article › Communication

LB0002 a first in class therapeutic nanoparticle for specific targeting of anti-citrullinated protein antibody ameliorates serum transfer and collagen induced arthritis

Khatri, S., Hansen, J., Clausen, M. H., Kragstrup, T. W., Hung, S. C., Mellins, E. & Astakhova, K., 2020, In: Annals of the Rheumatic Diseases. 79, 1, p. 208-208

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Library Design Strategies to Accelerate Fragment-Based Drug Discovery

Troelsen, N. S. & Clausen, M. H., 2020, In: Chemistry - A European Journal. 26, 50, p. 11391-11403

Research output: Contribution to journal › Review › peer-review

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Microscale thermophoresis as a powerful tool for screening glycosyltransferases involved in cell wall biosynthesis

Shao, W., Sharma, R., Clausen, M. H. & Scheller, H. V., 2020, In: Plant Methods. 16, 1, 12 p., 99.

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Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention

Hansen, A. E., Henriksen, J. R., Jølck, R. I., Fliedner, F. P., Bruun, L. M., Scherman, J., Jensen, A. I., Munck Af Rosenschöld, P., Moorman, L., Kurbegovic, S., de Blanck, S. R., Larsen, K. R., Clementsen, P. F., Christensen, A. N., Clausen, M. H., Wang, W., Kempen, P., Christensen, M., Viby, N. E. & Persson, G. & 6 others, Larsen, R., Conradsen, K., McEvoy, F. J., Kjaer, A., Eriksen, T. & Andresen, T. L., 1 Aug 2020, In: Science Advances. 6, 34, 12 p., eabb5353.

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S-Glycosides: Synthesis of S-linked Arabinoxylan Oligosaccharides

Romanó, C., Jiang, H., Boos, I. & Clausen, M. H., 2020, In: Organic & Biomolecular Chemistry. 18, p. 2696-2701

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The 3F Library: Fluorinated Fsp3-rich Fragments for Expeditious 19F-NMR-based Screening

Troelsen, N. S., Shanina, E., Gonzalez-Romero, D., Dankova, D., Jensen, I. S. A., Sniady, K. J., Nami, F., Zhang, H., Rademacher, C., Cuenda, A., Gotfredsen, C. H. & Clausen, M. H., 2020, In: Angewandte Chemie. 131, 6, p. 2224-2230

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The 3F Library: Fluorinated Fsp3-rich Fragments for Expeditious 19F-NMR-based Screening

Troelsen, N. S., Shanina, E., Gonzalez-Romero, D., Dankova, D., Jensen, I. S. A., Sniady, K. J., Nami, F., Zhang, H., Rademacher, C., Cuenda, A., Gotfredsen, C. H. & Clausen, M. H., 2020, In: Angewandte Chemie International Edition. 59, 6, p. 2204-2210

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The Regulation of Floral Colour Change in Pleroma raddianum (DC.) Gardner

Rezende, F. M., Clausen, M. H., Rossi, M. & Furlan, C. M., 2020, In: Molecules. 25, 20, 18 p., 4664.

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2019

Acylated Flavonoid Glycosides are the Main Pigments that Determine the Flower Colour of the Brazilian Native Tree Tibouchina pulchra (Cham.) Cogn.

Rezende, F. M., Ferreira, M. J. P., Clausen, M. H., Rossi, M. & Furlan, C. M., 2019, In: Molecules. 24, 4, 16 p., 718.

Research output: Contribution to journal › Journal article › Research › peer-review

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Chemical biology of plant cell wall glycans

Clausen, M. H., 2019, 256th ACS National Meeting. American Chemical Society, Vol. 256. CARB 88. (American Chemical Society. Abstracts of Papers (at the National Meeting)).

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology

Brennecke, P., Rasina, D., Aubi, O., Herzog, K., Lanskron, J., Cautain, B., Vicente, F., Quintana, J., Stechmann, B., Brea, J., Kolanowski, J., Pilarski, R., Orzaez, M., Pienda-Lucena, A., Laraia, L., Nami, F., Zielenkiewicz, P., Paruch, K., Hansen, E. & von Kries, J. & 19 others, Neuenschwander, M., Specker, E., Bartunek, P., Simova, S., Lesinikowski, Z., Krauss, S., Lëhtio, L., Bilitewski, U., Broenstrup, M., Tásken, K., Lickert, H., Clausen, M. H., Andersen, J., Vicent, M., Genilloud, O., Martinez, A., Nazaré, M., Gribbon, P. & Fecke, W., 2019, In: SLAS DISCOVERY: Advancing Life Sciences R&D. 24, 3, p. 398-413 16 p.

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Generation of a Heteropolycyclic and Sp³-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/DielsAlder and ROM-RCM Reaction Sequence

Flagstad, T., Azevedo, C., Troelsen, N. S., Min, G., Macé, Y., Willaume, A., Guilleux, R., Velay, M., Bonnet, K., Morgentin, R., Nielsen, T. E. & Clausen, M. H., 2019, In: European Journal of Organic Chemistry. 2019, 5, p. 1061-1076 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

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Implications of Byproduct Chemistry in Nanoparticle Synthesis

Stappen, F. N., Enemark-Rasmussen, K., Junor, G. P., Clausen, M. H., Zhang, J. & Engelbrekt, C., 2019, In: Journal of Physical Chemistry C. 123, 41, p. 25402-25411 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

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Prodrug strategies for targeted therapy triggered by reactive oxygen species

Peiro Cadahia, J., Previtali, V., Troelsen, N. S. & Clausen, M. H., 2019, In: MedChemComm. 10, 9, p. 1531-1549 19 p.

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ROS101,A Novel Targeted Methotrexate Prodrug, Selectively Activated by Reactive Oxygen Species (ROS) Shows Reduced Tixicity in Rat CIA Model of Rheumatic Arthritis

Previtali, V., Woodworth, N., Hopkins, M. H., Petersen, J. H., Ahnfelt-Ronne, I. & Clausen, M. H., 2019, In: Annals of the Rheumatic Diseases. 78, Suppl. 1, p. A62-A63 2 p., P142.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Substrate specificity of novel GH16 endo-β-(1→3)-galactanases acting on linear and branched β-(1→3)-1 galactooligosaccharides

Kalomoiri, P., Holck, J., Coulomb, L., Boos, I., Enemark-Rasmussen, K., Spodsberg, N., Monrad, R. N. & Clausen, M. H., 2019, In: Journal of Biotechnology. 290, p. 44-52

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Synthesis and oligomerization of 10,16-dihydroxyhexadecanoyl esters with different head-groups for the study of CUS1 selectivity

San Segundo, I. M., Scavée, G. M. L., Pedersen, S. B. R., Segerson, N., Rose, J. K. C. & Clausen, M. H., 2019, In: European Journal of Organic Chemistry. 2019, 33, p. 5704-5708

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Towards a synthetic strategy for the ten canonical carrageenan oligosaccharides – synthesis of a protected γ-carrageenan tetrasaccharide

Kinnaert, C. & Clausen, M. H., 2019, In: European Journal of Organic Chemistry. 2019, 20, p. 3236-3243 8 p.

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2018

A Tomato Tocopherol Binding Protein Sheds Light on Intracellular α-tocopherol Metabolism in Plants

Bermúdez, L., del Pozo, T., Lira, B. S., de Godoy, F., Boos, I., Romanó, C., Previtali, V., Almeida, J., Bréhélin, C., Asis, R., Quadrana, L., Demarco, D., Alseekh, S., Salinas Gamboa, R., Pérez-Flores, L., Dominguez, P. G., Rothan, C., Fernie, A. R., González, M. & Stocker, A. & 4 others, Hemmerle, A., Clausen, M. H., Carrari, F. & Rossi, M., 2018, In: Plant and Cell Physiology. p. 2188-2203 16 p.

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Bi-functional glycosyltransferases catalyze both extension and termination of pectic galactan oligosaccharides

Laursen, T., Stonebloom, S. H., Pidatala, V. R., Birdseye, D. S., Clausen, M. H., Mortimer, J. C. & Scheller, H. V., 2018, In: Plant Journal. 94, 2, p. 340-351 12 p.

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Branched pectic galactan in phloem-sieve-element cell walls: implications for cell mechanics

Torode, T. A., O'Neill, R. E., Marcus, S. E., Cornuault, V., Pose, S., Lauder, R. P., Kracun, S. K., Gro Rydahl, M., Andersen, M. C. F., Willats, W. G. T., Braybrook, S. A., Townsend, B. J., Clausen, M. H. & Knox, J. P., 2018, In: Plant Physiology. 176, 2, p. 1547-1558

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Enzyme activity assay system and devices

Kracun, S. (Inventor), Schückel, J. (Inventor), Willats, W. G. T. (Inventor) & Clausen, M. H. (Inventor), 2018, IPC No. B01L3/00; C12Q1/00, Patent No. US2018133712 , 17 May 2018, Priority date 26 May 2016, Priority No. DK2015PA70311

Research output: Patent

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Injectable iodine-125 labeled tissue marker for radioactive localization of non-palpable breast lesions

Schaarup-Jensen, H., Jensen, A. I., Hansen, A. E., El Ali, H. H., Hammershøj, P., Jølck, R. I., Kjær, A., Andresen, T. L. & Clausen, M. H., 2018, In: Acta Biomaterialia. 65, p. 197-202

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Iridium Catalysis: Reductive Conversion of Glucan to Xylan

Pedersen, M. J., Madsen, R. & Clausen, M. H., 2018, In: Chemical Communications. 54, 8, p. 952-955

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Methotrexate Prodrugs Sensitive to Reactive Oxygen Species for the Improved Treatment of Rheumatoid Arthritis

Andersen, N. S., Peiro Cadahia, J., Previtali, V., Bondebjerg, J., Hansen, C. A., Hansen, A. E., Andresen, T. L. & Clausen, M. H., 2018, In: European Journal of Medicinal Chemistry. 156, p. 738-746

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Petasis/Diels-Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production

Flagstad, T., Azevedo, C. M. G., Min, G., Willaume, A., Morgentin, R., Nielsen, T. E. & Clausen, M. H., 2018, In: European Journal of Organic Chemistry. 2018, 36, p. 5023-5029 8 p.

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Mads Hartvig Clausen

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