Research output per year
Research output per year
Personal profile
Other information
Visiting researcher, Centre for Plant Sciences, University of Leeds, UK, 2002.Profile
My research group has special interest in chemical biology, i.e. using synthetic chemistry to provide tool compounds for answering biological questions. This overall research theme includes development of synthetic methodology for generation of small molecule libraries, drug delivery including prodrug synthesis, medicinal chemistry, vaccine development, and plant cell wall polysaccharides and polyesters and plant cell wall polysaccharides. Major contributions include synthesis of oligosaccharides related to plant cell wall glycans and their use to characterize mAbs and enzymes; design and synthesis of shape-diverse, sp3-rich HTS compounds and fragments; prodrugs activated by ROS for treatment of inflammatory disease; development of carbohydrate-based vaccines.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Ph.D. Organic Chemistry, Technical University of Denmark
1999 → 2002
M.Sc. Chemistry, Technical University of Denmark
1993 → 1999
External positions
Associate Professor, Technical University of Denmark
2009 → 2013
Assistant Professor, Technical University of Denmark
2004 → 2008
Postdoctoral Fellow, Harvard University
2002 → 2004
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Collaborations and top research areas from the last five years
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Publications
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Alligamycin A, an antifungal β-lactone spiroketal macrolide from Streptomyces iranensis
Yang, Z., Qiao, Y., Strøbech, E., Morth, J. P., Walther, G., Jørgensen, T. S., Lum, K. Y., Peschel, G., Rosenbaum, M. A., Previtali, V., Clausen, M. H., Lukassen, M. V., Gotfredsen, C. H., Kurzai, O., Weber, T. & Ding, L., 2024, In: Nature Communications. 15, 12 p., 9259.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile35 Downloads (Orbit) -
An intranasal cationic liposomal polysaccharide vaccine elicits humoral immune responses against Streptococcus pneumoniae
Wei, P., Romanò, C., Li, C., Clergeaud, G., Andresen, T. L., Henriksen, J. R., Hansen, A. E. & Clausen, M. H., 2024, In: Communications Biology. 7, 1, 11 p., 1158.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Downloads (Orbit) -
Chemical synthesis and immunological evaluation of cancer vaccines based on ganglioside antigens and α-galactosylceramide
Romanò, C., Jiang, H., Tahvili, S., Wei, P., Keiding, U. B., Clergeaud, G., Skovbakke, S. L., Blomberg, A. L., Hafkenscheid, L., Henriksen, J. R., Andresen, T. L., Goletz, S., Hansen, A. E., Christensen, D. & Clausen, M. H., 2024, In: RSC Medicinal Chemistry. 15, 8, p. 2718-2728Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile44 Downloads (Orbit) -
Chemical synthesis of natural and azido-modified UDP-rhamnose and -arabinofuranose for glycan array-based characterization of plant glycosyltransferases
Pasini, I., Ruprecht, C., Osswald, U., Bittmann, A., Maltrovsky, L., Romanò, C., Clausen, M. H. & Pfrengle, F., 2024, In: Chemical Communications. 60, 70, p. 9368-9371Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of SulfoCy5- and SulfoCy7-αGalCer Probes as Chemical Tools for Investigating the Uptake of Liposomal αGalCer Conjugates by Antigen Presenting Cells
Romanò, C., Mark Lund, P., Wei, P., Jiang, H., Stoll, C. & Clausen, M. H., 2024, In: European Journal of Organic Chemistry. 27, 48, 7 p., e202400998.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile14 Downloads (Orbit)
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Discovery of recruiters of bacterial endoribonucleases
Mercorelli, N. (PhD Student), Clausen, M. H. (Main Supervisor), Gotfredsen, C. H. (Supervisor) & Mack, M. (Supervisor)
01/03/2025 → 29/02/2028
Project: PhD
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Regioselectivity in enzymatic carbohydrate synthesis
Makrygianni, V. (PhD Student), Zeuner, B. (Main Supervisor) & Clausen, M. H. (Supervisor)
01/09/2024 → 31/08/2027
Project: PhD
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Synthesis and evaluation of natural product-inspired compound collections
Hansen, O. S. (PhD Student), Laraia, L. (Main Supervisor) & Clausen, M. H. (Supervisor)
01/09/2024 → 31/08/2027
Project: PhD
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Chemical biology and assay development for identifying inhibitors of glycosyl transferases
Lasisi, G. (PhD Student), Clausen, M. H. (Main Supervisor), Laraia, L. (Supervisor) & Rapp, E. (Supervisor)
15/05/2024 → 14/05/2027
Project: PhD
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New polarizing agents for Dynamic Nuclear Polarization
Riis, R. (PhD Student), Ardenkjær-Larsen, J. H. (Main Supervisor), Clausen, M. H. (Supervisor) & Lohse, A. (Supervisor)
01/03/2024 → 28/02/2027
Project: PhD
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23rd International Symposium on Glycoconjugates
Clausen, M. H. (Participant)
16 May 2015Activity: Attending an event › Participating in or organising a conference
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Chemical Biology of the Plant Cell Wall
Clausen, M. H. (Invited speaker)
5 May 2015 → 6 May 2015Activity: Talks and presentations › Conference presentations