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Research Output 1996 2020

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Journal article
2020

Development of a high-throughput real-time PCR system for detection of enzootic pathogens in pigs

Goecke, N. B., Hjulsager, C. K., Krog, J. S., Skovgaard, K. & Larsen, L. E., 2020, (Accepted/In press) In : Journal of Veterinary Diagnostic Investigation.

Research output: Contribution to journalJournal articleResearchpeer-review

2019
44 Downloads (Pure)

Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination

Ryt-Hansen, P., Pedersen, A. G., Larsen, I., Krog, J. S., Kristensen, C. S. & Larsen, L. E., 2019, In : PLOS ONE. 14, 11, 23 p., e0224854.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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164 Downloads (Pure)

A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 Cells

Xie, J., Trus, I., Oh, D., Kvisgaard, L. K., Rappe, J. C. F., Ruggli, N., Vanderheijden, N., Larsen, L. E., Lefèvre, F. & Nauwynck, H. J., 2019, In : Viruses. 11, 1, 17 p., 36.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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47 Downloads (Pure)

Limited impact of influenza A virus vaccination of piglets in an enzootic infected sow herd

Ryt-Hansen, P., Larsen, I., Kristensen, C. S., Krog, J. S. & Larsen, L. E., 2019, In : Research in Veterinary Science. 127, p. 47-56

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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83 Downloads (Pure)

Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies

Ryt-Hansen, P., Larsen, I., Kristensen, C. S., Krog, J. S., Wacheck, S. & Larsen, L. E., 2019, In : Veterinary Research. 50, 1, 10 p., 36.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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126 Downloads (Pure)

Tracing Hepatitis E Virus in Pigs From Birth to Slaughter

Krog, J. S., Larsen, L. E. & Østergaard Breum, S., 2019, In : Frontiers in Veterinary Science. 6, 7 p., 50.

Research output: Contribution to journalJournal articleResearchpeer-review

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2018

Animal Models for Influenza A Virus Infection Incorporating the Involvement of Innate Host Defenses: Enhanced Translational Value of the Porcine Model

Starbæk, S. M. R., Brogaard, L., Dawson, H. D., Smith, A. D., Heegaard, P. M. H., Larsen, L. E., Jungersen, G. & Skovgaard, K., 2018, In : I L A R Journal. 59, 3, p. 323-337 15 p., ily009.

Research output: Contribution to journalJournal articleResearchpeer-review

154 Downloads (Pure)

Comparison of serum pools and oral fluid samples for detection of porcine circovirus type 2 by quantitative real-time PCR in finisher pigs

Nielsen, G. B., Nielsen, J. P., Haugegaard, J., Leth, S. C., Larsen, L. E., Kristensen, C. S., Pedersen, K. S., Stege, H., Hjulsager, C. K. & Houe, H., 2018, In : Porcine Health Management. 4, 2, 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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130 Downloads (Pure)

Diarrhoea in neonatal piglets: a case control study on microbiological findings

Kongsted, H., Pedersen, K., Hjulsager, C. K., Larsen, L. E., Pedersen, K. S., Jorsal, S. E. & Bækbo, P., 2018, In : Porcine Health Management. 4, 7 p., 17.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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240 Downloads (Pure)

Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs

Kristensen, C. S., Kvisgaard, L. K., Pawlowski, M., Holmgaard Carlsen, S., Hjulsager, C. K., Heegaard, P. M. H., Bøtner, A., Stadejek, T., Haugegaard, S. & Larsen, L. E., 2018, In : Vaccine. 36, 2, p. 227-236

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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415 Downloads (Pure)

Evaluation of ELISA and haemagglutination inhibition as screening tests in serosurveillance for H5/H7 avian influenza in commercial chicken flocks

Arnold, M. E., Slomka, M. J., Breed, A. C., Hjulsager, C. K., Pritz-Verschuren, S., Venema-Kemper, S., Bouwstra, R. J., Trebbien, R., Zohari, S., Ceeraz, V., Larsen, L. E., Manvell, R. J., Koch, G. & Brown, I. H., 2018, In : Epidemiology and Infection. p. 1-8

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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33 Downloads (Pure)

Full-genome sequencing of porcine circovirus 3 field strains from Denmark, Italy and Spain demonstrates a high within-Europe genetic heterogeneity

Franzo, G., Legnardi, M., Hjulsager, C. K., Klaumann, F., Larsen, L. E., Segales, J. & Drigo, M., 2018, In : Transboundary and Emerging Diseases. 65, 3, p. 602-606 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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41 Downloads (Pure)

Højpatogen fugleinfluenza med subtypen H5N6 er forblevet i Danmark

Hjulsager, C. K. & Larsen, L. E., 2018, In : Dansk Veterinaertidsskrift. 11, p. 47-47

Research output: Contribution to journalJournal articleCommunication

Open Access
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195 Downloads (Pure)

IFN-λ and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs

Brogaard, L., Larsen, L. E., Heegaard, P. M. H., Anthon, C., Gorodkin, J., Duerrwald, R. & Skovgaard, K., 2018, In : P L o S One. 13, 4, 23 p., e0194765.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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158 Downloads (Pure)

Subtyping of Swine Influenza Viruses Using a High-Throughput Real-Time PCR Platform

Goecke, N. B., Krog, J. S., Hjulsager, C. K., Skovgaard, K., Harder, T. C., Breum, S. Ø. & Larsen, L. E., 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 12 p., 165.

Research output: Contribution to journalJournal articleResearchpeer-review

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2017
102 Downloads (Pure)

Evolutionary analysis of whole-genome sequences confirms inter-farm transmission of Aleutian mink disease virus

Hagberg, E. E., Pedersen, A. G., Larsen, L. E. & Krarup, A., 2017, In : Journal of General Virology. 98, 6, p. 1360-1371

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Få styr på influenza

Ryt-Hansen, P. & Larsen, L. E., 2017, In : Svin. 2017, Oktober, p. 40-40

Research output: Contribution to journalJournal articleCommunication

166 Downloads (Pure)

Genetic and biological characterization of a Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2)causing significant clinical disease in the field

Kvisgaard, L. K., Larsen, L. E., Hjulsager, C. K., Bøtner, A., Rathkjen, P. H., Heegaard, P. M. H., Bisgaard, N. P., Nielsen, J. & Hansen, M. S., 2017, In : Veterinary Microbiology. 211, p. 74-83

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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157 Downloads (Pure)

Global phylogenetic analysis of contemporary aleutian mink disease viruses (AMDVs)

Ryt-Hansen, P., Hagberg, E. E., Chriél, M., Struve, T., Pedersen, A. G., Larsen, L. E. & Hjulsager, C. K., 2017, In : Virology Journal. 14, 1, 231.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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98 Downloads (Pure)

Identification of cross-reacting T-cell epitopes in structural and non-structural proteins of swine and pandemic H1N1 influenza A virus strains in pigs

Baratelli, M., Pedersen, L. E., Trebbien, R., Larsen, L. E., Jungersen, G., Blanco, E., Nielsen, J. & Montoya, M., 2017, In : Journal of General Virology. 98, 5, p. 895-899

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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197 Downloads (Pure)

Leaching of viruses and other microorganisms naturally occurring in pig slurry to tile drains on a well-structured loamy field in Denmark

Krog, J. S., Forslund, A., Larsen, L. E., Dalsgaard, A., Kjaer, J., Olsen, P. & Schultz, A. C., 2017, In : Hydrogeology Journal. 25, 4, p. 1045-1062

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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31 Downloads (Pure)

Mink kan også have influenza

Hjulsager, C. K., Krog, J. S., Larsen, G., Chriél, M. & Larsen, L. E., 2017, In : Faglig Årsberetning. 2017, p. 102-105

Research output: Contribution to journalJournal articleResearch

Open Access
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282 Downloads (Pure)

No evidence of enteric viral involvement in the new neonatal porcine diarrhoea syndrome in Danish pigs

Goecke, N. B., Hjulsager, C. K., Kongsted, H., Boye, M., Rasmussen, S., Granberg, F., Fischer, T. K., Midgley, S. E., Rasmussen, L. D., Angen, Ø., Nielsen, J. P., Jorsal, S. E. L. & Larsen, L. E., 2017, In : B M C Veterinary Research. 13, 1, 11 p., 315.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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153 Downloads (Pure)

Nyt virus beskrevet hos svin – Porcint circovirus type 3 (PCV3)

Larsen, L. E. & Sonne Kristensen, C., 2017, In : Dansk Svineproduktion. 2017, juli, 3 p., NOTAT NR. 1721.

Research output: Contribution to journalJournal articleCommunication

Open Access
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189 Downloads (Pure)

Outbreak tracking of Aleutian mink disease virus (AMDV) using partial NS1 gene sequencing

Ryt-Hansen, P., Hjulsager, C. K., Hagberg, E. E., Chriél, M., Struve, T., Pedersen, A. G. & Larsen, L. E., 2017, In : Virology Journal. 14, 119, 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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Pathogenicity of three genetically diverse strains of PRRSV Type 1 in specific pathogen free pigs

Stadejek, T., Larsen, L. E., Podgórska, K., Bøtner, A., Botti, S., Dolka, I., Fabisiak, M., Heegaard, P. M. H., Hjulsager, C. K., Huć, T., Kvisgaard, L. K., Sapierzyński, R. & Nielsen, J., 2017, In : Veterinary Microbiology. 209, p. 13-19

Research output: Contribution to journalJournal articleResearchpeer-review

33 Downloads (Pure)

PCV2 er påvist i lymfeknuder fra børe indsendt til USK

Thorup, F., Haugegaard, S., Kristensen, C. S., Hjulsager, C. K., Larsen, L. E. & Jensen, T. K., 2017, In : Dansk Svineproduktion. 2017, december, 8 p., ERFARING NR. 1716.

Research output: Contribution to journalJournal articleCommunication

Open Access
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154 Downloads (Pure)

Prediction and in vitro verification of potential CTL epitopes conserved among PRRSV-2 strains

Welner, S., Nielsen, M., Rasmussen, M., Buus, S., Jungersen, G. & Larsen, L. E., 2017, In : Immunogenetics. 69, 10, p. 689-702

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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180 Downloads (Pure)

Triple-reassortant influenza A virus with H3 of human seasonal origin, NA of swine origin, and internal A(H1N1) pandemic 2009 genes is established in Danish pigs

Krog, J. S., Hjulsager, C. K., Larsen, M. A. & Larsen, L. E., 2017, In : Influenza and Other Respiratory Viruses. 11, 3, p. 298-303 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2016
346 Downloads (Pure)

A fast and robust method for whole genome sequencing of the Aleutian Mink Disease Virus (AMDV) genome

Hagberg, E. E., Krarup, A., Fahnøe, U., Larsen, L. E., Dam-Tuxen, R. & Pedersen, A. G., 2016, In : Journal of Virological Methods. 234, p. 43-51 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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First characterization of avian influenza viruses from Greenland 2014

Hartby, C. M., Krog, J. S., Ravn Merkel, F., Holm, E., Larsen, L. E. & Hjulsager, C. K., 2016, In : Avian Diseases. 60, 1S, p. 302-310

Research output: Contribution to journalJournal articleResearchpeer-review

214 Downloads (Pure)

Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain

Trus, I., Frydas, I. S., Reddy, V. R. A. P., Bonckaert, C., Li, Y., Kvisgaard, L. K., Larsen, L. E. & Nauwynck, H. J., 2016, In : Veterinary Research. 47, 1, 9 p., 15.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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197 Downloads (Pure)

Rapid detection and subtyping of European swine influenza viruses in porcine clinical samples by haemagglutinin- and neuraminidase-specific tetra- and triplex real-time RT-PCRs

Henritzi, D., Zhao, N., Starick, E., Simon, G., Krog, J. S., Larsen, L. E., Reid, S. M., Brown, I. H., Chiapponi, C., Foni, E., Wacheck, S., Schmid, P., Beer, M., Hoffmann, B. & Harder, T. C., 2016, In : Influenza and Other Respiratory Viruses. 10, 6, p. 504-517 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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200 Downloads (Pure)

The global antigenic diversity of swine influenza A viruses

Lewis, N. S., Russell, C. A., Langat, P., Anderson, T. K., Berger, K., Bielejec, F., Burke, D. F., Dudas, G., Fonville, J. M., Fouchier, R. A., Kellam, P., Koel, B. F., Lemey, P., Nguyen, T., Nuansrichy, B., Peiris, J. M., Saito, T., Simon, G., Skepner, E., Takemae, N. & 8 others, consortium, ESNIP., Webby, R. J., Van Reeth, K., Brookes, S. M., Larsen, L. E., Watson, S. J., Brown, I. H. & Vincent, A. L., 2016, In : eLife. 5, 17 p., e12217.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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232 Downloads (Pure)

The Non-structural Protein 5 and Matrix Protein Are Antigenic Targets of T Cell Immunity to Genotype 1 Porcine Reproductive and Respiratory Syndrome Viruses

Mokhtar, H., Pedrera, M., Frossard, J-P., Biffar, L., Hammer, S. E., Kvisgaard, L. K., Larsen, L. E., Stewart, G. R., Somavarapu, S., Steinbach, F. & Graham, S. P., 2016, In : Frontiers in Immunology. 7, 14 p., 40.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2015
53 Downloads (Pure)

Beskytter de eksisterende vacciner godt nok mod PCV2-mutant (PCV2d)?

Larsen, L. E., Krog, J. S. & Hjulsager, C. K., 2015, In : Dansk Veterinaertidsskrift. 13, p. 48-48

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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71 Downloads (Pure)

Danske PPV-stammer har ændret sig genetisk

Hjulsager, C. K., Krog, J. S. & Larsen, L. E., 2015, In : Dansk Veterinaertidsskrift. 15, p. 47-47

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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177 Downloads (Pure)

Different clinical, virological, serological and tissue tropism outcomes of two new and one old Belgian type 1 subtype 1 porcine reproductive and respiratory virus (PRRSV) isolates

Frydas, I. S., Trus, I., Kvisgaard, L. K., Bonckaert, C., Reddy, V. R. A. P., Li, Y., Larsen, L. E. & Nauwynck, H. J., 2015, In : Veterinary Research. 46, 17 p., 37.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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49 Downloads (Pure)

Fugleinfluenzavirus H10N7 spredte sig blandt danske sæler i 2014

Hjulsager, C. K., Krog, J. S., Hansen, M. S., Chriél, M. & Larsen, L. E., 2015, In : Dansk Veterinaertidsskrift. 9, p. 42-42

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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193 Downloads (Pure)

Influenza A(H10N7) Virus in Dead Harbor Seals, Denmark

Krog, J. S., Hansen, M. S., Holm, E., Hjulsager, C. K., Chriél, M., Pedersen, K., Andresen, L. O., Abildstrøm, M., Jensen, T. H. & Larsen, L. E., 2015, In : EMERGING INFECTIOUS DISEASES. 21, 4, p. 684-687 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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679 Downloads (Pure)

Molecular Epidemiology and Evolution of Influenza Viruses Circulating within European Swine between 2009 and 2013

J. Watson, S., Langat, P., M. Reid, S., Tsan-Yuk Lam, T., Cotten, M., Kelly, M., Van Reeth, K., Qiu, Y., Simon, G., Bonin, E., Foni, E., Chiapponi, C., Larsen, L. E., Hjulsager, C. K., Markowska-Daniel, I., Urbaniak, K., Dürrwald, R., Schlegel, M., Huovilainen, A., Davidson, I. & 10 others, Dán, Á., Loeffen, W., Edwards, S., Bublot, M., Vila, T., Maldonado, J., Valls, L., H. Brown, I., Pybus, O. G. & Kellam, P., 2015, In : Journal of Virology. 89, 19, p. 9920-9931

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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121 Downloads (Pure)

New reassortant and enzootic European swine influenza 1 viruses transmits efficiently through direct contact in the ferret model

Fobian, K., P. Fabrizio, T., Yoon, S-W., Hansen, M. S., Webby, R. J. & Larsen, L. E., 2015, In : Journal of General Virology. 96, 7, p. 1603-1612

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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1 Downloads (Pure)

Overvågning af influenza afslører flere subtyper

Krog, J. S., Hjulsager, C. K. & Larsen, L. E., 2015, In : Dyrlægen. 6, p. 34-38

Research output: Contribution to journalJournal articleResearch

213 Downloads (Pure)

Spatial analysis and temporal trends of porcine reproductive and respiratory syndrome in Denmark from 2007 to 2010 based on laboratory submission data

Lopes Antunes, A. C., Hisham Beshara Halasa, T., Lauritsen, K. T., Kristensen, C. S., Larsen, L. E. & Toft, N., 2015, In : B M C Veterinary Research. 11, 1, 11 p., 303.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2014
534 Downloads (Pure)

Analysis of ORF5 and Full-Length Genome Sequences of Porcine Reproductive and Respiratory Syndrome Virus Isolates of Genotypes 1 and 2 Retrieved Worldwide Provides Evidence that Recombination Is a Common Phenomenon and May Produce Mosaic Isolates

Martín-Valls, G. E., Kvisgaard, L. K., Tello, M., Darwich, L., Cortey, M., Burgara-Estrella, A. J., Hernández, J., Larsen, L. E. & Mateu, E., 2014, In : Journal of Virology. 88, 6, p. 3170-3181

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Effects of level of social contact on dairy calf behavior and health

Jensen, M. B. & Larsen, L. E., 2014, In : Journal of Dairy Science. 97, 8, p. 5035-5044

Research output: Contribution to journalJournal articleResearchpeer-review

186 Downloads (Pure)

Enteric porcine viruses in farmed shellfish in Denmark

Krog, J. S., Larsen, L. E. & Schultz, A. C., 2014, In : International Journal of Food Microbiology. 186, p. 105-109

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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282 Downloads (Pure)

European Surveillance Network for Influenza in Pigs: Surveillance Programs, Diagnostic Tools and Swine Influenza Virus Subtypes Identified in 14 European Countries from 2010 to 2013

Simon, G., Larsen, L. E., Duerrwald, R., Foni, E., Harder, T., Van Reeth, K., Markowska-Daniel, I., Reid, S. M., Dan, A., Maldonado, J., Huovilainen, A., Billinis, C., Davidson, I., Agueero, M., Vila, T., Herve, S., Breum, S. Ø., Chiapponi, C., Urbaniak, K., Kyriakis, C. S. & 3 others, Brown, I. H., Loeffen, W. & Consortium, ESNIP., 2014, In : PLOS ONE. 9, 12, 21 p., PMC4277368.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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199 Downloads (Pure)

Identification of swine influenza virus epitopes and analysis of multiple specificities expressed by cytotoxic T cell subsets

Pedersen, L. E., Breum, S. Ø., Riber, U., Larsen, L. E. & Jungersen, G., 2014, In : Virology Journal. 11, 163, 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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357 Downloads (Pure)

Wildlife Reservoirs of Canine Distemper Virus Resulted in a Major Outbreak in Danish Farmed Mink (Neovison vison)

Trebbien, R., Chriél, M., Struve, T., Hjulsager, C. K., Larsen, G. & Larsen, L. E., 2014, In : PLOS ONE. 9, 1, 11 p., e85598.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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