20042021

Research output per year

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Research Output

2019
Open Access
File
21 Downloads (Pure)
2018

Efficient Oligo nucleotide mediated CRISPR-Cas9 Gene Editing in Aspergilli

Nødvig, C. S., Hoof, J. B., Kogle, M. E., Jarczynska, Z. D., Lehmbeck, J., Klitgaard, D. K. & Mortensen, U. H., 2018, In : Fungal Genetics and Biology. 115, p. 78-89

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
300 Downloads (Pure)

Genome editing: CRISPR-Cas9

Hoof, J. B., Nødvig, C. S. & Mortensen, U. H., 2018, Fungal Genomics: methods and protocols. de Vries, R. P., Tsang, A. & Grigoriev, I. V. (eds.). 2 ed. Humana Press, Vol. 1775. p. 119-132 (Methods in Molecular Biology, Vol. 1775).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
227 Downloads (Pure)

Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication

Theobald, S., Vesth, T. C., Rendsvig, J. K., Nielsen, K. F., Riley, R., de Abreu, L. M., Salamov, A., Frisvad, J. C., Larsen, T. O., Andersen, M. R. & Hoof, J. B., 2018, In : Scientific Reports. 8, 12 p., 17957.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
194 Downloads (Pure)
2017

A CRISPR/Cas9 based toolbox for efficient genome editing of filamentous fungi

Mortensen, U. H., Nødvig, C. S., Jarczynska, Z. D., Nielsen, M. L., Kirchner, F. H. & Hoof, J. B., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
File
258 Downloads (Pure)

Biosynthesis of acurin A and B in Aspergillus aculeatus

Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Petersen, T. I., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
File
155 Downloads (Pure)

Biosynthesis of acurin A and B in Aspergillus aculeatus

Hoof, J. B., Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Petersen, T. I., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
File
93 Downloads (Pure)

Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9

Nielsen, M. L., Petersen, T. I., Rasmussen, K. B., Thrane, U., Hoof, J. B., Larsen, T. O. & Mortensen, U. H., 2017, In : P L o S One. 12, 1, 9 p., e0169712.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
323 Downloads (Pure)
2016

Detection of fungal growth and its influence on gypsum wallboard – in the process of creating sustainable building materials

Lewinska, A. M., Lilje, O., Foley, M., Trimby, P., Bjerring, M., Vosegaard, T., Peuhkuri, R. H., Rode, C., Grumsen, F. B., Hoof, J. B. & Andersen, B., 2016. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access

Diversity in Secondary Metabolites Including Mycotoxins from Strains of Aspergillus Section Nigri Isolated from Raw Cashew Nuts from Benin, West Africa

Lamboni, L. Y., Nielsen, K. F., Linnemann, A. R., Gezgin, Y., Hell, K., J. R. Nout, M., Smid, E. J., Tamo, M., van Boekel, M. A. J. S., Hoof, J. B. & Frisvad, J. C., 2016, In : P L o S One. 11, 10, 14 p., e0164310.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
256 Downloads (Pure)

Effect of secretory pathway gene overexpression on secretion of a fluorescent reporter protein in Aspergillus nidulans

Schalén, M., Anyaogu, D. C., Hoof, J. B. & Workman, M., 2016, In : Fungal Biology and Biotechnology. 3, 1, 14 p., 3.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
352 Downloads (Pure)

Genetic engineering in the Aspergillus genus

Hoof, J. B., Nødvig, C. S. & Mortensen, U. H., 2016, Book of abstracts from the 13th European Conference on Fungal Genetics. p. 609-609 1 p. CS9W25

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
94 Downloads (Pure)

Heterologous production of immunosuppressant mycophenolic acid in Aspergillus nidulans

Jarczynska, Z. D., Hoof, J. B., Aasted, F., Holm, D. K., Patil, K. R., Nielsen, K. F. & Mortensen, U. H., 2016, Book of abstracts from the 13th European Conference on Fungal Genetics. p. 457-457 1 p. CS5T72

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
150 Downloads (Pure)

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

Nielsen, M. L., Petersen, T. I., Petersen, L. M., Mortensen, U. H., Andersen, M. R., Hoof, J. B. & Larsen, T. O., 2016, In : P L o S One. 11, 8, 18 p., e0161199.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
295 Downloads (Pure)

Oligonucleotide directed mutagenesis of Aspergilli genomes using CRISPR-Cas9 technology

Nødvig, C. S., Hoof, J. B. & Mortensen, U. H., 2016, Book of abstracts from the 13th European Conference on Fungal Genetics. p. 599-599 1 p. CS9W15

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
106 Downloads (Pure)

Production of novel synthetic natural products by engineering of fungal PKS-NRPS hybrids

Nielsen, M. L., Petersen, T. I., Mortensen, U. H., Andersen, M. R., Hoof, J. B. & Larsen, T. O., 2016, Book of abstracts from the 13th European Conference on Fungal Genetics. p. 453-453 1 p. CS5T68

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
149 Downloads (Pure)

Rapid detection and identification of Stachybotrys and Chaetomium species using tissue PCR analysis

Lewinska, A. M., Peuhkuri, R. H., Rode, C., Andersen, B. & Hoof, J. B., 2016, In : Journal of Microbiological Methods. 130, p. 115-122 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Seamless gene editing in Aspergillus species, using CRISPR-Cas9

Nødvig, C. S., Hoof, J. B. & Mortensen, U. H., 2016. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access

Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum

Lewinska, A. M., Hoof, J. B., Peuhkuri, R. H., Rode, C., Lilje, O., Foley, M., Trimby, P. & Andersen, B., 2016, In : Journal of Microbiological Methods. 129, p. 28-38 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2015

A CRISPR/Cas9 system for genetic engineering of filamentous fungi

Nødvig, C. S., Hoof, J. B., Kogle, M. E. & Mortensen, U. H., 2015, Book of Abstracts. DTU's Sustain Conference 2015. Lyngby: Technical University of Denmark, 1 p. B-16

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
304 Downloads (Pure)

A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi

Nødvig, C. S., Nielsen, J. B., Kogle, M. E. & Mortensen, U. H., 2015, In : P L o S One. 10, 7, 18 p., e0133085.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
391 Downloads (Pure)

Combining Stable Isotope Labeling and Molecular Networking for Biosynthetic Pathway Characterization

Klitgaard, A., Nielsen, J. B., Frandsen, R. J. N., Andersen, M. R. & Nielsen, K. F., 2015, In : Analytical Chemistry. 87, 13, p. 6520-6526 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Chaetomium and Stachybotrys in water-damaged buildings

Andersen, B., Lewinska, A. M., Nielsen, J. B., Dosen, I., Nielsen, K. F., Peuhkuri, R. H., Rode, C., Clausen, G. & Thrane, U., 2014.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
File
1079 Downloads (Pure)

Novel DNA barcodes for detection, idenfication and tracking of stachybotrys and chaetomium species

Lewinska, A. M., Hoof, J. B., Peuhkuri, R. H., Rode, C. & Andersen, B., 2014, Proceedings of Indoor Air 2014. International Society of Indoor Air Quality and Climate, p. 281-288 8 p.

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

2013

Accurate prediction of secondary metabolite gene clusters in filamentous fungi.

Andersen, M. R., Nielsen, J. B., Klitgaard, A., Petersen, L. M., Zachariasen, M., Hansen, T. J., Holberg Blicher, L., Gotfredsen, C. H., Larsen, T. O., Nielsen, K. F. & Mortensen, U. H., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. E99-E107

Research output: Contribution to journalJournal articleResearchpeer-review

Aspergillus nidulans Synthesize Insect Juvenile Hormones upon Expression of a Heterologous Regulatory Protein and in Response to Grazing by Drosophila melanogaster Larvae.

Nielsen, M. T., Klejnstrup, M. L., Rohlfs, M., Anyaogu, D. C., Nielsen, J. B., Gotfredsen, C. H., Andersen, M. R., Hansen, B. G., Mortensen, U. H. & Larsen, T. O., 2013, In : PloS one.. 8, 8, 11 p., e73369.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
415 Downloads (Pure)

Heterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach

Nielsen, M. T., Nielsen, J. B., Anyaogu, D. C., Holm, D. K., Nielsen, K. F., Larsen, T. O. & Mortensen, U. H., 2013, In : P L o S One. 8, 8, e72871.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
310 Downloads (Pure)

Supercluster takes a walk on the wild side

Nielsen, J. B., Andersen, M. R. & Mortensen, U. H., 2013, In : Trends in Microbiology. 21, 12, p. 617-618

Research output: Contribution to journalJournal articleResearchpeer-review

2012

Adaptive evolution of drug targets in producer and non-producer organisms

Hansen, B. G., Sun, X. E., Genee, H. J., Kaas, C. S., Nielsen, J. B., Frisvad, J. C. & Hedstrom, L., 2012, In : Biochemical Journal. 441, 1, p. 219-226

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
526 Downloads (Pure)

Characterization of the AN6448 cluster in Aspergillus nidulans

Nielsen, J. B., Klejnstrup, M. L., Khorsand-Jamal, P., Holm, D. K., Nielsen, M. L., Kabat, A. M., Rank, C., Gotfredsen, C. H., Larsen, T. O. & Mortensen, U. H., 2012, In : Planta Medica. 78, 11, p. 1113-1113

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Chemical analysis of a genome wide polyketide synthase gene deletion library in Aspergillus nidulans

Larsen, T. O., Klejnstrup, M. L., Nielsen, J. B., Holm, D. K., Petersen, L. M., Klitgaard, A., Nielsen, K. F., Andersen, M. R. & Mortensen, U. H., 2012.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

File
106 Downloads (Pure)

Genetics of Polyketide Metabolism in Aspergillus nidulans

Klejnstrup, M. L., Frandsen, R. J. N., Holm, D. K., Nielsen, M. T., Mortensen, U. H., Larsen, T. O. & Nielsen, J. B., 2012, In : Metabolites. 2, 1, p. 100-133

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
442 Downloads (Pure)

Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

Hansen, B. G., Mnich, E., Nielsen, K. F., Nielsen, J. B., Nielsen, M. T., Mortensen, U. H., Larsen, T. O. & Patil, K. R., 2012, In : Applied and Environmental Microbiology. 78, 14, p. 4908-4913

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
466 Downloads (Pure)
2011

A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans

Nielsen, M. L., Nielsen, J. B., Rank, C., Klejnstrup, M. L., Holm, D. K., Brogaard, K. H., Hansen, B. G., Frisvad, J. C., Larsen, T. O. & Mortensen, U. H., 2011, In : F E M S Microbiology Letters. 321, 2, p. 157-166

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi

Hansen, B. G., Genee, H. J., Kaas, C. S., Nielsen, J. B., Regueira, T. B. H., Mortensen, U. H., Frisvad, J. C. & Patil, K. R., 2011, In : B M C Microbiology. 11, 1, p. 202

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
212 Downloads (Pure)

Characterization of Emericella nidulans RodA and DewA hydrophobin mutants

Jensen, B. G., Nielsen, J. B., Pedersen, M. H., Søndergaard, I., Frisvad, J. C. & Nielsen, K. F., 2011.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

File
94 Downloads (Pure)

Characterization of Emericella nidulans RodA and DewA hydrophobin mutants

Jensen, B. G., Nielsen, J. B., Pedersen, M. H., Søndergaard, I., Frisvad, J. C. & Nielsen, K. F., 2011.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

File
97 Downloads (Pure)

Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88

Andersen, M. R., Salazar, M. P., Schaap, P. J., van de Vondervoort, P. J. I., Culley, D., Thykær, J., Frisvad, J. C., Nielsen, K. F., Albang, R., Albermann, K., Berka, R. M., Braus, G. H., Braus-Stromeyer, S. A., Corrochano, L. M., Dai, Z., van Dijck, P. W. M., Hofmann, G., Lasure, L. L., Magnuson, J. K., Menke, H. & 27 others, Meijer, M., Meijer, S. L., Nielsen, J. B., Nielsen, M. L., van Ooyen, A. J. J., Pel, H. J., Poulsen, L., Samson, R. A., Stam, H., Tsang, A., van den Brink, J. M., Atkins, A., Aerts, A., Shapiro, H., Pangilinan, J., Salamov, A., Lou, Y., Lindquist, E., Lucas, S., Grimwood, J., Grigoriev, I. V., Kubicek, C. P., Martinez, D., van Peij, N. N. M. E., Roubos, J. A., Nielsen, J. & Baker, S. E., 2011, In : Genome Research. 21, 6, p. 885-897

Research output: Contribution to journalJournal articleResearchpeer-review

2 Downloads (Pure)

Heterologous expression of polyketides in fungi and optimization by an in silico guided approach

Mølgaard, L., Hansen, B. G., Nielsen, J. B., Patil, K. R., Thykær, J. & Mortensen, U. H., 2011.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
File
129 Downloads (Pure)

Mapping of polyketide biosynthesis pathways in Aspergillus nidulans using a genome wide PKS gene deletion library

Larsen, T. O., Rank, C., Klejnstrup, M. L., Nielsen, J. B., Holm, D. K., Brogaard, K. H., Hansen, B. G., Frisvad, J. C. & Mortensen, U. H., 2011.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Versatile Enzyme Expression and Characterization System for Aspergillus nidulans, with the Penicillium brevicompactum Polyketide Synthase Gene from the Mycophenolic Acid Gene Cluster as a Test Case

Hansen, B. G., Salomonsen, B., Nielsen, M. T., Nielsen, J. B., Hansen, N. B., Nielsen, K. F., Regueira, T. U. B., Nielsen, J., Patil, K. R. & Mortensen, U. H., 2011, In : Applied and Environmental Microbiology. 77, 9, p. 3044-3051

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)
2009

Development of high-throughput methods for heterologous expression in fungi

Hansen, B. G., Nielsen, J. B., Nielsen, M. L., Patil, K. R. & Mortensen, U. H., 2009.

Research output: Contribution to conferencePosterResearch

Open Access
File
68 Downloads (Pure)

Dissection of polyketide biosynthesis pathway in Aspergillus nidulans

Nielsen, M. L., Brogaard, K. H., Rank, C., Nielsen, J. B., Larsen, T. O., Frisvad, J. C. & Mortensen, U. H., 2009.

Research output: Contribution to conferencePosterResearch

Improving gene targeting in Aspergillus nidulans for high-throughput experiments

Nielsen, J. B., Nielsen, M. L., Hansen, B. G. & Mortensen, U. H., 2009.

Research output: Contribution to conferencePosterResearch

Pigment production in response to deficiency in DNA repair

Nielsen, J. B., Rank, C., Mapari, S. S., Nielsen, M. L., Larsen, T. O., Frisvad, J. C. & Mortensen, U. H., 2009.

Research output: Contribution to conferencePosterResearch

Open Access
File
102 Downloads (Pure)
Open Access
File
935 Downloads (Pure)
2008

Fungal pigments in stress response - new therapeutics?

Nielsen, J. B., Mapari, S. S., Nielsen, M. L., Larsen, T. O., Frisvad, J. C. & Mortensen, U. H., 2008.

Research output: Contribution to conferencePosterResearchpeer-review

High-throughput strategies for construction of mutant libraries in filamentous fungi

Nielsen, M. L., Nielsen, J. B., Hansen, B. G. & Mortensen, U. H., 2008.

Research output: Contribution to conferenceConference abstract for conferenceResearch

Transient disruption of non-homologous end-joining facilitates targeted genome manipulations in the filamentous fungus Aspergillus nidulans

Nielsen, J. B., Nielsen, M. L. & Mortensen, U. H., 2008, In : Fungal Genetics and Biology. 45, 3, p. 165-170

Research output: Contribution to journalJournal articleResearchpeer-review